Synthetic Route of 130284-53-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 130284-53-6, name is 5-Bromo-6-chloropyridin-3-amine, molecular formula is C5H4BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To the solution of 5-bromo-6-chloro-3-pyridinamine (0. 200g, 0.97 mmol) in 5 ml CH2CI2was added 3-phenylpropanal (0. 195 g, 1. 45mmol) followed by Na (OAc) 3BH (0. 411g, 1.94 mmol). The reaction mixture was stirred at room temperature for 1 h. The solution was quenched with water (5 mi) and product was extracted with CH2CI2 (5 mix3). The organic layer was dried over Na2SO4, concentrated. The compound was purified by flash column chromatography to give 0. 136g product (yield 50%).
According to the analysis of related databases, 130284-53-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/85227; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem