Category: 13210-52-1

Adding a certain compound to certain chemical reactions, such as: 13210-52-1, 1-(3-Aminopyridin-4-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1-(3-Aminopyridin-4-yl)ethanone, blongs to pyridine-derivatives compound. Safety of 1-(3-Aminopyridin-4-yl)ethanone

To a solution of 1-(3-aminopyridin-4-yl)ethanone (0.9 g, 6.61 mmol) in DMF (10 mL) was added NBS (2.53 g, 14.21 mmol). The reaction mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with ethyl acetate and saturated NaHCO3 solution. The organic layers (extracted two times) were washed with saturated NaHCO3 solution, dried over MgSO4. The filtrate was concentrated in vacuo. The residue was purified by flash chromatography. The product was eluted with 0-20% ethyl acetate in hexane to give the desired product as a white solid (1.55 g, 80%); HPLC: RT=0.88 min (H2O/ACN with 0.05% TFA, Waters Acquity SDS C18, 2.1×50 mm, 1.7-mum particles, gradient=1.8 min, wavelength=220 nm); MS (ES): m/z=292.8, 294.8 [M+H]+; 1H NMR (400 MHz, CDCl3) delta ppm 7.65 (s, 1H), 6.73 (br. s., 2H), 2.62 (s, 3H).

The synthetic route of 13210-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bristol-Myers Squibb Company; Fink, Brian E.; Zhao, Yufen; Borzilleri, Robert M.; Zhang, Liping; Kim, Kyoung S.; Kamau, Muthoni G.; Tebben, Andrew J.; (162 pag.)US2016/176871; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 13210-52-1 , The common heterocyclic compound, 13210-52-1, name is 1-(3-Aminopyridin-4-yl)ethanone, molecular formula is C7H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-(2-Methyl-l,3-dioxolan-2-yl)pyridin-3-amine. The mixture of P- TOLUENESULFONIC ACID MONOHYDRATE (0.065 g, 0.340 mmol), ETHYLENE GLYCOL (0.379 mL, 6.80 mmol) and l-(3-aminopyridin-4- yl)ethanone (0.4631 g, 3.40 mmol) in Toluene (5 mL) was heat to reflux for over night. The reaction was diluted with ethyl acetate and washed with water three times. The ethyl acetate layer was separated, dried (Na2S04), filtered and concentrated. Flash column eluted with ethyl acetate in hexane from 0 to 25% to 50% gave the desired product (59.8 mg obtained, 8% yield) as a wax. MS(ES+) m/e 181 [M+H]+; 1H NMR (400MHz, CHLOROFORM-d) delta 8.01 (s, 1H), 7.95 (d, J=5.0 Hz, 1H), 7.18 (d, J=4.8 Hz, 1H), 4.46 (br. s., 2H), 4.09 – 4.04 (m, 2H), 3.82 – 3.77 (m, 2H), 1.66 (s, 3H).

The synthetic route of 13210-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LUO, Guanglin; CHEN, Ling; DUBOWCHIK, Gene M.; JACUTIN-PORTE, Swanee E.; VRUDHULA, Vivekananda M.; PAN, Senliang; SIVAPRAKASAM, Prasanna; MACOR, John E.; WO2015/69594; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem