Reference of 1321612-85-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1321612-85-4, name is 3-Fluoro-5-iodopyridin-2-amine, molecular formula is C5H4FIN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a 50-mL round-bottomed flask, the solution of 4-bromobenzenethiol (1.0 g, 5.3 mmol) and 3-fluoro-5-iodo-2-pyridinamine (0.63 g , 2.7 mmol) in DMSO (10 mL) was degassed by purging with argon gas at room temperature for 10 min. K2C03 (2.18 g, 15.9 mmol) and Cul (0.05 g, 0.26 mmol) were added sequentially to the above reaction mixture at room temperature under argon atmosphere. The reaction mixture was heated overnight at 100 C under argon atmosphere. The reaction mixture was cooled to room temperature and filtered through a pad of Celite (diatomaceous earth). The filtrate was diluted with cold water (50 mL) and ethyl acetate (100 mL). The EtOAc layer was separated, washed with water, brine, dried over anhydrous Na2S04, filtered and concentrated under reduced pressure. The residue obtained was purified by silica gel (100 to 200 mesh) column chromatography (elution 30% EtOAc-hexanes) to give 5-((4-bromophenyl)sulfanyl)-3-fluoro-2-pyridinamine (400 mg) as a white solid.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1321612-85-4, 3-Fluoro-5-iodopyridin-2-amine.
Reference:
Patent; AMGEN INC.; ASHTON, Kate; BOURBEAU, Matthew, Paul; HONG, Fang-Tsao; LIU, Longbin; NISHIMURA, Nobuko; NORMAN, Mark, H.; POON, Steve, F.; STEC, Markian, M.; ST. JEAN, David, J., JR; TAMAYO, Nuria, A.; YANG, Kevin, C.; WO2013/123444; (2013); A1;,
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