Related Products of 136117-71-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 136117-71-0, name is (6-Bromoimidazo[1,2-a]pyridin-2-yl)methanol, molecular formula is C8H7BrN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 38 (66.1 mg, 0.44 mmol) and (6-bromoimidazo[1 ,2-a]pyridin-2-yl)- methanol (100 mg, 0.44 mmol) were dissolved in acetonitrile (10 mL) and pyridiniumptoluenesulfonate (443 mg, 1.76 mmol) was added. The resulting mixture was heated at 80C overnight. The resulting mixture was cooled and evaporated onto silica. Purification by column chromatography (0-15% MeOH in DCM) gave a clear oil, whichwas freeze-dried to give the title compound (50 mg, 32%), 7:3 mixture of diastereomers, as a white solid.Major diastereomer (trans): H (400 MHz, DMSO-d6) 7.80 (dd, 1H, J0.6, 1.9 Hz), 7.57 (dd, 1H,J0.6, 8.8 Hz), 7.48 (m, 1H), 7.42 (m, 1H), 7.36 (dd, 1H,J9.5, 1.9 Hz), 7.29 (t, 1H,J7.3 Hz), 7.04 (d, 1H,J7.4 Hz), 6.97 (d, 1H,J2.5 Hz), 5.63 (qd, 1H,J6.3, 2.6 Hz), 5.22 (t, 1H, J5.7 Hz), 4.54 (m, 2H), 1.52 (d, 3H, J6.3 Hz.Minor diastereomer (cis): H (400 MHz, DMSO-d6) 7.78 (m, 1H), 7.57 (m, 1H), 7.48 (m, 1H), 7.42 (m, 1H), 7.36 (dd, 1H, J9.5, 1.9 Hz), 7.30 (t, 1H, J7.3 Hz), 6.92 (m,1H), 6.82 (d, 1H, J2.8 Hz), 5.40 (m, 1H), 5.28 (t, 1H, J5.7 Hz), 4.66 (d, 2H, J5.6 Hz),1.66 (d, 3H, J6.4 Hz). LCMS MH m/z 359.60.
According to the analysis of related databases, 136117-71-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB BIOPHARMA SPRL; BROWN, Julien Alistair; CALMIANO, Mark Daniel; JONES, Elizabeth Pearl; KROEPLIEN, Boris; REUBERSON, James Thomas; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning; WO2015/86512; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem