In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14548-45-9, name is (4-Bromophenyl)(pyridin-3-yl)methanone, the common compound, a new synthetic route is introduced below. Quality Control of (4-Bromophenyl)(pyridin-3-yl)methanone
In a 250ml three-necked bottle, under nitrogen protection,Add 0.01 mol of starting material 1, 0.012 mol of compound C1,150 ml of a mixed solution of toluene and ethanol was stirred and mixed.Then add 0.02 mol Na2CO3, 1¡Á10-4 mol Pd(PPh3)4,Heat to 105 C, reflux reaction for 24 hours, sample the plate,Show no bromine residue remaining, the reaction is complete; naturally cool to room temperature,Filtration, the filtrate was subjected to vacuum distillation (-0.09 MPa, 85 C), and passed through a neutral silica gel column to obtain the desired product. HPLC purity was 99.2%.Yield 76.3%
The synthetic route of 14548-45-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Wu Xiuqin; Zhang Zhaochao; Li Chong; Zhang Xiaoqing; (51 pag.)CN109796438; (2019); A;,
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