Application of 154012-15-4 , The common heterocyclic compound, 154012-15-4, name is Ethyl 4,6-dichloro-5-nitronicotinate, molecular formula is C8H6Cl2N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 4, 6-dichloro-5-nitro-nicotinic acid ethyl ester (1.00 g, 3.77 MMOL) in CH2CI2 (10 mL) at 0 C was added Et3N (0. 58 mL, 4.15 MMOL) and (3,3- dimethylbutyl) amine (0.56 mL, 4.15 MMOL). After 30 min at RT, the reaction was diluted with CH2CI2, washed with water and dried over MGSO4. The solvent was removed in vacuo to provide the desired compound as a yellow solid (1.25 g). MS (ES+) m/z 330.2 (M+H) +.
The synthetic route of 154012-15-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/11700; (2005); A1;,
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