Category: 1620-55-9

Analyzing the synthesis route of 1620-55-9

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1620-55-9, 1-Phenyl-2-(pyridin-4-yl)ethanone.

Reference of 1620-55-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1620-55-9, name is 1-Phenyl-2-(pyridin-4-yl)ethanone, molecular formula is C13H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of (2) (1.98 g, 10.0 mmol), ammonium acetate (23.2 g, 300 mmol), and sodium cyanoborohydride (4.63 g, 69.9 mmol) in EPA (100 mL) was heated at 80 C overnight. The mixture was evaporated under reduced pressure to remove EPA. The residue was diluted with water, and basified with NaOH (2M) to pH > 7. The aqueous layer was extracted with dichloromethane (3x). The pooled organic layer was removed under vacuum. The residue was purified by chromatography on silica gel (100% ethyl acetate, then 10% saturated ammonia methanol in dichloromethane) to give l-phenyl-2-(pyridin-4- yl)ethanamine (3) as a clear oil (0.780 g, 3.94 mmol, 39% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1620-55-9, 1-Phenyl-2-(pyridin-4-yl)ethanone.

Reference:
Patent; ALLERGAN, INC.; WO2009/91759; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem