Category: 1678-53-1

Application of 1678-53-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1678-53-1, name is 3-Methyl-4-nitropyridine, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.

To a solution of 250 mg (1.86 mmol) of furopyridine 71, 618 mg (4.47 mmol) of nitropicoline 35 in 8 mL of THF was added 4.47 mL (4.47 mmol) of a 1 M solution of TBAF and 732 mg (5.59 mmol) of Huenig’s base. The mixture was stirred at 60 C for 5 days at which point a slurry had formed. The mixture was cooled to room temperature, filtered, and the product washed with 5 mL of THF and dried under vacuum/N2 sweep overnight to give 350 mg (59%) of dimeric furopyridine 72 as a colorless solid: mp 228e229 C; 1 H NMR (500 MHz, CDCl3) d 3.25 (dd, 2H, J 15.8 and 8.1 Hz), 3.72 (dd, 2H, J 15.8 and 9.6 Hz), 5.88 (dd, 2H, J 9.6 and 8.1 Hz), 6.84 (d, 2H, J 5.6 Hz), 7.42 (s, 4H), 8.40 (m, 4H); 13C NMR (125 MHz, CDCl3) d 35.5, 84.8, 105.6, 123.4, 126.1, 141.0, 145.9, 150.2, 166.0. Anal. Calcd. For C20H16N2O2: C, 75.93; H, 5.10; N, 8.86. Found: C, 75.88; H, 5.07; N, 8.89.

The chemical industry reduces the impact on the environment during synthesis 1678-53-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kuethe, Jeffrey T.; Tetrahedron; vol. 75; 34; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1678-53-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1678-53-1, name is 3-Methyl-4-nitropyridine, molecular formula is C6H6N2O2, molecular weight is 138.12, as common compound, the synthetic route is as follows.

To a solution of 250 mg (1.86 mmol) of furopyridine 71, 618 mg (4.47 mmol) of nitropicoline 35 in 8 mL of THF was added 4.47 mL (4.47 mmol) of a 1 M solution of TBAF and 732 mg (5.59 mmol) of Huenig’s base. The mixture was stirred at 60 C for 5 days at which point a slurry had formed. The mixture was cooled to room temperature, filtered, and the product washed with 5 mL of THF and dried under vacuum/N2 sweep overnight to give 350 mg (59%) of dimeric furopyridine 72 as a colorless solid: mp 228e229 C; 1 H NMR (500 MHz, CDCl3) d 3.25 (dd, 2H, J 15.8 and 8.1 Hz), 3.72 (dd, 2H, J 15.8 and 9.6 Hz), 5.88 (dd, 2H, J 9.6 and 8.1 Hz), 6.84 (d, 2H, J 5.6 Hz), 7.42 (s, 4H), 8.40 (m, 4H); 13C NMR (125 MHz, CDCl3) d 35.5, 84.8, 105.6, 123.4, 126.1, 141.0, 145.9, 150.2, 166.0. Anal. Calcd. For C20H16N2O2: C, 75.93; H, 5.10; N, 8.86. Found: C, 75.88; H, 5.07; N, 8.89.

The chemical industry reduces the impact on the environment during synthesis 1678-53-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kuethe, Jeffrey T.; Tetrahedron; vol. 75; 34; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1678-53-1 ,Some common heterocyclic compound, 1678-53-1, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred mixture of 1.00 mmol of nitropicoline 35 or 63, 1.20 mmol of the appropriate benzaldehyde, and 1.5 mmol of Huenig’s base in THF (7 mL/g of nitropicoline 35/63) was added 1.3 mmol of a 1 M THF solution of TBAF. The resulting mixture was heated 60 C for 1.5e2.0 h in the case of 2,3-dihydrofuro[3,2-c] pyridines or for 18 h in the case of 2,3-dihydrofuro[2,3-b]pyridines. After cooling to room temperature, the reactions were quenched with sat. aqueous NH4Cl. The solution was extracted with EtOAc, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel chromatography as specified above.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1678-53-1, its application will become more common.

Reference:
Article; Kuethe, Jeffrey T.; Tetrahedron; vol. 75; 34; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem