Related Products of 185315-51-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 185315-51-9, name is 2-(5-Chloropyridin-2-yl)acetonitrile, molecular formula is C7H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of ethylo-mesitylsulfonylacetohydroxamic acid (2.14 g, 7.50 mmol) in 1,4-dioxane (4 mL)was added a 70% aqueous solution ofhydrogenperchlorate (0.8 mL, 9.2 mmol), and the mixture was stirred at 0C for 0.5 h. After the addition of ice-water, theprecipitate was collected. The cake was dissolved in dichloromethane (20 mL)and dried over Na2SO4. To themixture was added a solution of 2-pyridineaceonitrile substrate(5.00 mmol) in dichloromethane (5 mL), and then the mixture was stirred at roomtemperature for 1 h. The mixture was concentratedin vacuo to give 1-aminopyridinium2,4,6-trimethylbenzenesulfonate intermediate as a crude material. To a solutionof the crude material in methanol (25 mL) was added potassium carbonate (1.38g, 9.98 mmol) at 0C,and then the mixture was stirred at room temperature for 2 h. After the addition of water, the mixture wasextracted with ethyl acetate, then washed with water and brine, and then driedover Na2SO4. Themixture was concentrated in vacuo. Thecrude material waspurified by flash column chromatography on a silica gel(Hexane:AcOEt) togive 1a-g.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 185315-51-9, 2-(5-Chloropyridin-2-yl)acetonitrile.
Reference:
Article; Nishigaya, Yosuke; Umei, Kentaro; Yamamoto, Eri; Kohno, Yasushi; Seto, Shigeki; Tetrahedron Letters; vol. 55; 43; (2014); p. 5963 – 5966;,
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