Category: 188577-69-7

Application of 188577-69-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 188577-69-7, name is 3,4-Dichloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

2,7,8-Trichloro-imidazo[1,2-a]pyridine (17). 2-Amino-3,4-dichloropyridine, compound 5 (1.0 g, 6.1 mmol) was treated with ethyl bromoacetate (5.0 mL, 45.0 mmol) at 60 C. for 24 hours to give a white solid. This solid was removed by filtration, dissolved in water, treated with ion exchange resin and chlorinated with POCl3 as described above to give, after purification by flash chromatography (EtOAc/hexane 1:2, 15 cm*4 cm) and recrystallization from MeOH, 700 mg (52%) of compound 17 as white crystals. Compound 17: mp 220-221 C.; Rf 0.29 (EtOAc/hexane 1:2); 1H-NMR (360 MHz, CDCl3) delta7.93 (d, 1H J=7.15 Hz), 7.56 (s, 1H), 6.94 (d, 1H, J=7.15 Hz); 13C-NMR (90 MHz CDCl3) delta141.77 (C8a), 137.20 (C2), 129.87 (C7), 123.52 (C5), 121.30 (C8), 115.08 (C6), 110.39 (C3); UV lambdaax (EtOH) 304 (5250), 288 (5825), 233 (10434); (pH 11) 287 (6566), 232 (24612); (pH 1) 287 (8865), 231 (26610); HRMS m/z calcd for C7H3Cl3N2 219.9362, found 219.9355. Anal. Calcd for C7H3Cl3N2.1/4 H2O: C, 37.21; H, 1.56; N, 12.40. Found: C, 37.40; H, 1.46; N, 12.22.

According to the analysis of related databases, 188577-69-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Regents of the University of Michigan; US6214801; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 188577-69-7, name is 3,4-Dichloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 188577-69-7

3,4-dichloro-2-aminopyridine (500 mg, 3.07 mmol, prepared with reference to document: Synthetic Communications, 1997, 27(5), 861-870.) and 2-fluoro-4-nitrophenol (1.928 g, 12.27 mmol) were heated to 120 C. and melted, and stirred for 24 hrs. The molten was cooled to room temperature, and subjected to silica gel column chromatography (the eluent was dichloromethane to dichloromethane/methanol=50/1) for purification, to obtain a white solid (137 mg, 16%). 1H NMR (DMSO-d6, 300 MHz) delta 8.38 (dd, 1H, J=10.5, 2.4 Hz), 8.148.09 (m, 1H), 7.86 (d, 1H, J=5.4 Hz), 7.427.36 (m, 1H), 6.60 (br, 2H), 6.27 (d, 1H, J=5.4 Hz).

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Reference:
Patent; SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO., LTD; Cheng, Jianjun; Qin, Jihong; Ye, Bin; US2014/206679; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem