In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 189281-48-9, name is 2,4-Dichloro-5-fluoropyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 2,4-Dichloro-5-fluoropyridine
Example 10d6-Chloro-2-(4-chloro-phenyl)-3-fluoro-pyridine A solution of 2.2 g 2,4-chloro-5-fluoropyridine, 2.28 g 4-chlorophenylboronic acid and 0.6 g tetrakistriphenylphosphine palladium in 30 ml tetrahydrofuran was added 30 ml of a 10% a solution of potassium carbonate in water and the mixture was stirred at ambient temperature for 18 h. The reaction mixture was diluted with ethyl acetate and water. The phases were separated and the organic phase was washed water, 10% aqueous citric acid, 10% aqueous sodium bicarbonate and brine, dried over sodium sulfate and evaporated. The residue was purified by chromatography on silica gel with a gradient of heptane_dichloromethane=9:1 to 1:1 (only startspot was removed) The product fractions were collected and evaporated. The residue was subjected to Kugelrohr distillation at 0.03 mbar and 110 C. to yield 1.72 g of the title compound as colorless oil which solidified into white crystals. MS (EI) (M+H): 241 and 243:
The synthetic route of 189281-48-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hebeisen, Paul; Roever, Stephan; US2012/157476; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem