In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 192642-85-6, name is 2-(5-Bromopyridin-2-yl)acetic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C7H6BrNO2
To a suspension of delta-bromo-pyridin^-yl-acetic acid (0.87 g, 4.0 mmol) in THF (12 mL) was added HOBt (0.74 g, 4.8 mmol) and EDCI. HCI (0.85 g, 4.4 mmol) and stirred the resulting reaction mixture for 15-20min at room temperature followed by drop-wise addition of methyl amine (2.0 M in THF, 4.05 mL, 8.0 mmol). The resulting mixture was then continued to stir for 6-7 h at room temperature. After completion of reaction, water was added and extracted with ethyl acetate. The crude residue was purified over silica (60-120 M) using dichloromethane:methanol (97.5:2.5) to obtain the pale-yellow solid compound (0.25 g, 27%). 1H NMR (DMSO-d6, 400 MHz): delta 2.58 (d, J= 4.8 Hz, 3H), 3.57 (s, 2H)1 7.33 (d, J= 1 H), 7.96 (d, J= 2.4 Hz & 8.4 Hz, 1 H), 8.00 (br s, 1 H) and 8.58 (d, J= 2.4 Hz, 1 H). MS: 229.11 (M+H+).
The synthetic route of 192642-85-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PROLYSIS LTD; WO2009/74812; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem