Category: 197958-29-5

Sivudu, K. Samba published the artcileHighly efficient and reusable hydrogel-supported nano-palladium catalyst: Evaluation for Suzuki-Miyaura reaction in water, Application of 2-Pyridinylboronic acid, the publication is Journal of Molecular Catalysis A: Chemical (2008), 295(1-2), 10-17, database is CAplus.

Ligand-free, palladium-supported, poly(N-isopropylacrylamide-co-potassium methacrylate) [poly(NIPA-co-PMA)] hydrogel nanocomposite with different comonomer ratios were synthesized. The developed hydrogel-palladium composites were characterized by SEM, TEM, UV-vis DRS and x-ray diffraction. The catalytic performance of these hydrogel-palladium nanocomposites was examined for Suzuki-Miyaura cross-coupling reaction of aryl halides with arylboronic acids in an aqueous medium. The hydrogel with comonomer ratio of 8.8:1.6 mmol of NIPA:PMA exhibited optimum catalytic activity, which can be effectively reused 5-6 times without loss of catalytic activity.

Journal of Molecular Catalysis A: Chemical published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C7H5Cl2NO, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Stansfield, Ian published the artcileDevelopment of carboxylic acid replacements in indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase, Application In Synthesis of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(18), 5143-5149, database is CAplus and MEDLINE.

Allosteric inhibition of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase enzyme has recently emerged as a viable strategy toward blocking replication of viral RNA in cell-based systems. We report here 2 series of indole-N-acetamides, bearing physicochem. diverse carboxylic acid replacements, which show potent affinity for the NS5B enzyme with reduced potential for formation of glucuronide conjugates. E.g., indole-N-acetamide I was prepared in several steps from Me 2-bromo-3-cyclohexyl-5-indolecarboxylate. Preliminary optimization of these series furnished compounds that are potent in the blockade of subgenomic HCV RNA replication in HUH-7 cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C6H4KNO6S, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Picconi, Pietro published the artcileNovel pyridyl nitrofuranyl isoxazolines show antibacterial activity against multiple drug resistant Staphylococcus species, Name: 2-Pyridinylboronic acid, the publication is Bioorganic & Medicinal Chemistry (2017), 25(15), 3971-3979, database is CAplus and MEDLINE.

A novel series of pyridyl nitrofuranyl isoxazolines were synthesized and evaluated for their antibacterial activity against multiple drug resistant (MDR) Staphylococcus strains. Compounds with piperazine linker between the pyridyl group and isoxazoline ring showed better activity when compared to compounds without the piperazine linker. 3-Pyridyl nitrofuranyl isoxazoline with a piperazine linker was found to be more active than corresponding 2-and 4-pyridyl analogs with MICs in the range of 4-32 μg/mL against MDR Staphylococcus strains. The eukaryotic toxicity of the compounds was tested by MTT assay and were found to be non-toxic against both non-tumor lung fibroblast WI-38 and cervical cancer cell line HeLa. The most active pyridyl nitrofuranyl isoxazoline compound showed improved activity against a panel of Staphylococcus strains compared to nitrofuran group containing antibiotic nitrofurantoin.

Bioorganic & Medicinal Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Name: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shan, Zhenwei published the artcileDiscovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes, Product Details of C5H6BNO2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(6), 1731-1735, database is CAplus and MEDLINE.

A series of novel [1,2,3]-triazolopiperidine derivatives I (R = H, Me, CHF₂, CF₃, CO₂Me, CONH₂, CONMe₂, Ph, 4-F-C₆H₄, 4-Cl-C₆H₄, 4-CF₃-C₆H₄, 4-CN-C₆H₄, 3-CO₂Me-C₆H₄, 4-CONH₂-C₆H₄, 4-CONMe₂-C₆H₄,4-CO₂H-C₆H₄, 4-SO₂Me-C₆H₄, 4-Pyr, 2-Pyr, 2-furanyl, 3-furanyl, 2-thienyl, 3-thienyl, 4-oxazolyl) were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes, most of the compounds exhibited excellent in vitro potency (IC₅₀ <50 nM) against DPP-4. Among these, compound I (R = CF₃) with potent in vitro activity against DPP-4 and good pharmacokinetic profiles exhibited pronounced in vivo efficacy in an oral glucose tolerance test (OGTT) in ICR mice. On the base of these properties, compound I (R = CF₃) was selected as a potential new candidate for the treatment of type 2 diabetes.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C15H23BO2, Product Details of C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Oda, Mitsunori published the artcileSynthesis and properties of 2-(2-pyridyl)-1-azaazulene, Formula: C5H6BNO2, the publication is Tetrahedron Letters (2007), 48(26), 4471-4475, database is CAplus.

The title azaazulene (I) was synthesized either by reaction of tropone with N-[(2-pyridyl)acetyl]pyridinium iodide in the presence of ammonium acetate or by palladium-catalyzed cross-coupling between 2-halo-1-azaazulene and 2-substituted pyridine. The compound shows relatively stronger basicity compared with 2,2′-bipyridyl. While I showed no emission from the S₁ state but from the S₂ state like azulene does, the protonated species of I exhibited emission from the S₁ state. Cationic metal-dependent absorption and emission relating to complexation were also studied.

Tetrahedron Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ogino, Yoshio published the artcileSyntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1′-cyclohexan]-4′-yl]benzimidazole NPY Y5 receptor antagonists, Category: pyridine-derivatives, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(18), 4997-5001, database is CAplus and MEDLINE.

Syntheses and structure-activity relationships of a novel class of 2-[3-oxospiro[isobenzofuran-1(3H),1′-cyclohexan]-4′-yl]benzimidazole NPY Y5 receptor antagonists are described. Optimization of the lead compound (I) by incorporating substituents into the 5-position or into both the 5- and 6-positions of the benzimidazole core part led to the identification of two potent, selective, and orally bioavailable Y5 receptor antagonists (II (IC₅₀ = 3.3 nM) and III (IC₅₀ = 5.9 nM)).

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Yiding published the artcileDirect Copper-Catalyzed Three-Component Synthesis of Sulfonamides, Formula: C5H6BNO2, the publication is Journal of the American Chemical Society (2018), 140(28), 8781-8787, database is CAplus and MEDLINE.

Sulfonamides such as N-(phenylsulfonyl)morpholine were prepared in one step by coupling of aryl-, heteroaryl-, and alkenylboronic acids such as phenylboronic acid with cyclic and acyclic alkyl secondary amines such as morpholine and primary anilines and the bis(sulfur dioxide) complex of DABCO (DABSO) in the presence of Cu(OTf)₂ and 4,4′-dimethoxy-2,2′-bipyridine in DMSO. The method was used on gram scale and was used to prepare sulfonamides from drugs and drug fragments.

Journal of the American Chemical Society published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Murugan, Karthik published the artcileGreen-Synthesized Nickel Nanoparticles on Reduced Graphene Oxide as an Active and Selective Catalyst for Suzuki and Glaser-Hay Coupling Reactions, Computed Properties of 197958-29-5, the publication is Applied Organometallic Chemistry (2020), 34(9), e5778, database is CAplus.

The present work disclosed the potential catalytic application of the as-prepared RGO-Ni nanocomposite in Csp²-Csp² Suzuki type homocoupling and Csp-Csp Glaser-Hay coupling reactions. A mild and benign methodol. to synthesize biaryls Ar-Ar [Ar = Ph, 3-MeOC₆H₄, 2-pyridyl, etc.] and 1,3-diynes R-CC-CC-R [R = t-Bu, 3-FC₆H₄, 4-EtC₆H₄, etc.] was demonstrated using the nickel nanoparticles supported on reduced graphene oxide (RGO-Ni) as a heterogeneous catalyst which was prepared using green reagents. A series of substituted biaryls Ar-Ar and 1,3-diynes R-CC-CC-R was synthesized in good to excellent yields via reduced graphene oxide supported nickel nanoparticles catalyzed Suzuki coupling of arylboronic acids and Glaser-Hay coupling of terminal alkynes resp. using 1,4-dioxane as a benign solvent. The present ligand-free catalytic system proceeded smoothly under mild conditions, avoided noble and stoichiometric metal reagents and tolerated sensitive functional groups such as nitrogen and sulfur containing heteroaryl boronic acids. Hot filtration test unambiguously proved the true heterogeneity of the catalyst and which supported for the further reusability of the catalyst for several times without any change in the activity. The easy preparation and simple magnetic separation, stability and reusability revealed that as-prepared RGO-Ni as a versatile catalyst for the synthesis of polyaromatic compounds both in academia and industries.

Applied Organometallic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Fengtian published the artcile2,5-Dihydroxyterephthalic Acid Accelerated Cu(NO₃)₂.3H₂O-Catalyzed Homocoupling Reaction of Arylboronic Acids, Application of 2-Pyridinylboronic acid, the publication is Letters in Organic Chemistry (2020), 17(11), 877-883, database is CAplus.

A catalyst system derived from com. available Cu(NO₃)₂.3H₂O and 2,5-dihydroxyterephthalic acid is applied to the homocoupling reaction of arylboronic acids. This transformation provides a convenient approach to sym. biaryls with good to excellent yields (39%- 95%), and exhibits good functional group compatibility. Furthermore, biaryl can be prepared in gram quantities in good yield.

Letters in Organic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is 0, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cappelli, Andrea published the artcileDesign, Synthesis, and Preliminary Biological Evaluation of Pyrrolo[3,4-c]quinolin-1-one and Oxoisoindoline Derivatives as Aggrecanase Inhibitors, Application of 2-Pyridinylboronic acid, the publication is ChemMedChem (2010), 5(5), 739-748, database is CAplus and MEDLINE.

A small set of aggrecanase inhibitors based on the pyrrolo[3,4-c]quinolin-1-one or oxoisoindoline frameworks bearing a 4-(benzyloxy)phenyl substituent and different zinc binding groups were rationally designed and evaluated in silico by docking studies using the crystal structure of the ADAMTS-5 catalytic domain (PDB code: 3B8Z). The designed compounds were synthesized via straightforward routes and tested for their potential inhibitory activity against ADAMTS-5 and ADAMTS-4. Among the compounds containing the pyrrolo[3,4-c]quinolinone tricyclic system, hydroxamate derivative 2 b (I) inhibited both ADAMTS-5 and ADAMTS-4, with IC₅₀ values in the submicromolar range and an inhibitory profile very similar to that of reference carboxylate derivative 11. Conversely, the corresponding carboxylate derivative 2 a was significantly less active and unable to discriminate between ADAMTS-5 and -4. The structure-activity relationship anal. of pyrroloquinolinone derivatives 2 a-i suggests that the carboxylate or hydroxamate groups of compounds 2 a,b play a key role in the interaction of these compounds with ADAMTS-5 and -4. On the other hand, the oxoisoindoline derivatives 3 a,b lack significant ADAMTS-4 inhibitory activity and inhibit ADAMTS-5 showing IC₂₅ values in the micromolar range.

ChemMedChem published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem