Category: 26218-80-4

Adding a certain compound to certain chemical reactions, such as: 26218-80-4, Methyl 6-methoxynicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 6-methoxynicotinate, blongs to pyridine-derivatives compound. name: Methyl 6-methoxynicotinate

To a solution of methyl 6-methoxynicotinate (1.00 g, 5.98 mmol) in 20 mL of THF at 0 C under an atmosphere of nitrogen was added lithium aluminum hydride (1.0 M in THF, 9.0 mL, 9.0 mmol) dropwise. After 30 min, the reaction was warmed to rt, and after 30 mill, the reaction was recooled to 0 C, diluted with diethyl ether, and treated with water (0.34 mL), 15% aqueous sodium hydroxide (0.34 mL), and additional water (1.02 mL). The mixture was dried over magnesium sulfate and warmed to rt. After 15 min, the mixture was filtered through celite and concentrated in vacuo to provide (6-methoxypyridin-3-yl)methanol that gave a proton NMR spectra consistent with theory.

The synthetic route of 26218-80-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; GILBERT, Kevin, F.; WO2011/159554; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 26218-80-4 ,Some common heterocyclic compound, 26218-80-4, molecular formula is C8H9NO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(A) To a stirred solution of methyl 6-methoxynicotinate (14 g, 83.83 mmol, 1.0 eq) in THE (300 ml), NaBH4 (47.7 g, 1.257 mol, 15 eq) was added at RT, followed by MeOH (300 ml). The RM was stirred atRT for 12 h. Reaction progress was monitored by TLC. The RM was quenched with sat. NH4CI (100 ml), diluted with water (100 ml) and extracted with EtOAc (3 x 200 ml). The organic layer was washed with brine solution (100 ml), dried (Na2504), filtered and concentrated to afford the crude product, which upon CC (silica gel, 40% EtOAc in PE afforded (6-methoxypyridin-3-yl)methanol (10 g, 86%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26218-80-4, its application will become more common.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem