29241-60-9 | Pyridine-derivatives

The origin of a common compound about 29241-60-9

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 29241-60-9, 5-Bromo-2-chloro-3-methylpyridine.

Synthetic Route of 29241-60-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29241-60-9, name is 5-Bromo-2-chloro-3-methylpyridine, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[1120] To a solution of NaOMe (5.29 g, 98 mmol) in MeOH (500 mL) was added XLV1 (10 g, 49 mmol) by portionwise. The reaction mixture was heated to reflux overnight. The solution was cooled, quenched with water slowly, extracted with PE (100 mL x3). The combined organic layer was washed with brine and concentrated to give XLV-2 (8.0 g, 81% yield) as a white solid.

Reference:
Patent; INTERMUNE, INC.; RAMPHAL, Johnnie, Y.; BUCKMAN, Brad, Owen; EMAYAN, Kumaraswamy; NICHOLAS, John, Beamond; SEIWERT, Scott, D.; WO2015/153683; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

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Related Products of 29241-60-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29241-60-9, name is 5-Bromo-2-chloro-3-methylpyridine, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: n-BuLi (4.8 mL, 12 mmol) was added dropwise to a solution of 5-bromo-2- chloro-3-methylpyridine (2.1 g, 10.0 mmol) in THF (40 mL) at -78 C. Then DMF (1.5 g, 20 mmol) was added, and stirred for another 2 hours at -78 C. Methanol (12 mL) was added to quench the reaction. NaBH4 (1.1 g, 30 mmol) was added, and stirred for 0.5h. Ice water (40 mL) was added. The mixture was extracted with DCM (30 mL x 3). Combined organic layers was washed with brine, dried over anhydrous Na2S04, concentrated and purified by flash column chromatography (PE/EA=2/1) to give the product 5-2 as yellow oil. LC-MS: m/z = 158.1 [M+H]+.

Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 29241-60-9

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29241-60-9, name is 5-Bromo-2-chloro-3-methylpyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H5BrClN

To a solution of 5-bromo-2-chloro-3-methylpyridine (300 g, 1.45 mol) in MeOH (3 L) was added freshly prepared sodium methoxide (156 g, 2.9 mol), and the reaction mixture was heated to reflux and stirred overnight. The reaction mixture was quenched with acetic acid (600 mL) and concentrated under reduced pressure. The crude mixture was diluted with ethyl acetate (3 L) and washed with water (3 L). The aqueous layer was extracted with ethyl acetate (3 L) and the combined organic layers were washed with brine (3 L), dried over anhydrous MgSCL and evaporated under reduced pressure to provide crude 5-bromo-2-methoxy-3-methylpyridine (220 g, 75%). l NMR (300 MHz, CDCl3) d (s, 1 H), 7.47 (s, 1 H), 3.93 (s, 3 H), 2.05 (s, 3 H).

Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; CUNNINGHAM, Christian; BEROZA, Paul Powell; CRAWFORD, James John; LEE, Wendy; RENE, Olivier; ZBIEG, Jason Robert; LIAO, Jiangpeng; WANG, Tao; YU, Chen; (208 pag.)WO2020/51099; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem