Category: 30766-03-1

Related Products of 30766-03-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30766-03-1 as follows.

A mixture of 4-bromopicolinic acid ( 15 g, 75 mmol), methanamine hydrochloride (1 5 g, 75 mmol), HOBt (10 g, 75 mmol), EDCI (21 g, 75 mmol) and Et3N (41.5 mL, 300 mmol) in DMF(200 mL) was stirred at r.t. for 18 h. Water was added to the reaction mixture and the resulting mixture was filtered to afford 16 g of 78 as solid which was used directly in the next step. LCMS: m/z 215 (M+l )+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30766-03-1, its application will become more common.

Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio, G.; WO2013/43232; (2013); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30766-03-1, name is 4-Bromopicolinic acid, the common compound, a new synthetic route is introduced below. COA of Formula: C6H4BrNO2

Triethylamine (1.05 equiv.) was added to a suspension of 4-bromopicolinic acid in benzole (5 mL/mmol), followed by chloroformate (1.05 equiv.) and the reaction mixture stirred 1 h at RT. Triethylamine hydrochloride was filtered out and the filtrate evaporated to low bulk. The anhydride thus obtained was taken up in THF (5 mL/mmol) and added in drops to a suspension of lithium aluminium hydride (1 equiv.) in THF (2 mL/mmol) at -78 C. The mixture was stirred for 30 min. at -78 C., then sat. Na2SO4 sol. was added, filtered over celite, washed with EE and the organic phase was evaporated to low bulk. The raw product thus obtained was purified by column chromatography (30% EE in hexane) (yield approx. 50%).

The synthetic route of 30766-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gruenenthal GmbH; US2009/69320; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem