Category: 3510-66-5

The author of 《Synthesis of Hetero-multinuclear Metal Complexes by Site-Selective Redox Switching and Transmetalation on a Homo-multinuclear Complex》 were Ube, Hitoshi; Endo, Kenichi; Sato, Hiroyasu; Shionoya, Mitsuhiko. And the article was published in Journal of the American Chemical Society in 2019. Quality Control of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

Hetero-multinuclear metal complexes are a promising class of compounds applicable to photoluminescence, magnetism, and catalysis. The authors have developed a synthetic method for hetero-tetranuclear cobalt and nickel cage complexes [M4L3X6]n+ with a bipyridyl functionalized zinc porphyrin (L) by combining advantages of site-selective redox switching and transmetalation. First, a homo-tetranuclear CoII4 complex was converted to a mixed-valence CoIIICoII3 complex by site-selective oxidation, which was then transmetalated from CoII to NiII to form a heterometallic CoIIINiII3 complex. Finally, a CoIINiII3 complex was synthesized by metal-selective reduction on the CoIII site. The basic structural frameworks of the main products in the whole process starting from the CoII4 complex are isostructural. Notably, the CoIINiII3 complex was not accessible by direct mixing of ligand, CoII, and NiII. This method would provide an alternative strategy for highly selective synthesis of hetero-multinuclear metal complexes. In the experimental materials used by the author, we found 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Yan-Hua; Xie, Pei-Pei; Liu, Lei; Fan, Jun; Zhang, Zhuo-Zhuo; Hong, Xin; Shi, Bing-Feng published their research in Journal of the American Chemical Society in 2021. The article was titled 《Cp*Co(III)-Catalyzed Enantioselective Hydroarylation of Unactivated Terminal Alkenes via C-H Activation》.Application of 3510-66-5 The article contains the following contents:

Enantioselective hydroarylation of unactivated terminal alkenes RCH=CH2 (R = n-hexyl, benzyl, cyclohexylmethyl, etc.) constitutes a prominent challenge in organic chem. Synthesis of Cp*Co(III)-catalyzed asym. hydroarylation of unactivated aliphatic terminal alkenes assisted by a new type of tailor-made amino acid ligands. Critical to the chiral induction was the engaging of a novel noncovalent interaction (NCI), which has seldomly been disclosed in C-H activation area, arising from the mol. recognition among the organocobalt(III) intermediate, the coordinated alkene and the well-designed chiral ligand. A broad range of C2 alkylated indoles were obtained in high yields and excellent enantioselectivities. DFT calculations revealed the reaction mechanism and elucidated the origins of chiral induction in the stereodetermining alkene insertion step. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 3510-66-5In 2021 ,《Cobalt-Catalysed Asymmetric Addition and Alkylation of Secondary Phosphine Oxides for the Synthesis of P-Stereogenic Compounds》 appeared in Angewandte Chemie, International Edition. The author of the article were Wu, Zeng-Hua; Cheng, An-Qi; Yuan, Meng; Zhao, Ya-Xuan; Yang, Huai-Lan; Wei, Li-Hua; Wang, Huai-Yu; Wang, Tao; Zhang, Zunting; Duan, Wei-Liang. The article conveys some information:

Secondary pyridyl arylphosphine oxides undergo addition to activated double bonds and nucleophilic substitution with benzyl halides catalyzed by cobalt(II) complexes with chiral pincer isoindole-bis(oxazoline) ligands yielding P-chiral phosphine oxides ArPyP(O)R (Py = 2-pyridyl), which were converted into aryl and alkyl derivatives ArR1P(O)R by reaction with Grignard reagents R1MgX with minor loss of enantiopurity. The catalytic asym. synthesis of P-chiral phosphorus compounds is an important way to construct P-chiral ligands. Herein, we report a new strategy that adopts the pyridinyl moiety as the coordinating group in the cobalt-catalyzed asym. nucleophilic addition/alkylation of secondary phosphine oxides. A series of tertiary phosphine oxides were generated with up to 99% yield and 99.5% ee, and with broad functional-group tolerance. Mechanistic studies reveal that (R)-secondary phosphine oxides preferentially interact with the cobalt catalysts to produce P-stereogenic compounds In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Recommanded Product: 3510-66-5) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 3510-66-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C6H6BrNIn 2021 ,《Tetrahydroindazole inhibitors of CDK2/cyclin complexes》 was published in European Journal of Medicinal Chemistry. The article was written by Lee, Jae Chul; Hong, Kwon Ho; Becker, Andreas; Tash, Joseph S.; Schonbrunn, Ernst; Georg, Gunda I.. The article contains the following contents:

Over 50 tetrahydroindazoles I [R = 2-pyridyl, thiazol-2-yl, pyrimidin-4-yl, etc.] were synthesized after I [R = 2-pyridyl] was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogs was evaluated by inhibition of CDK2 enzyme complexes with various cyclins. Analogs I [R = thiazol-2-yl, pyrimidin-4-yl] showed 3-fold better binding affinity for CDK2 and 2- to 10-fold improved inhibitory activity against CDK2/cyclin A1, E, and O compared to screening hit 3. The data from the enzyme and binding assays indicate that the binding of the analogs to a CDK2/cyclin complex is favored over binding to free CDK2. Computational anal. was used to predict a potential binding site at the CDK2/cyclin E1 interface. In the experiment, the researchers used 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation》 were Roy, Satyajit; Khatua, Hillol; Das, Sandip Kumar; Chattopadhyay, Buddhadeb. And the article was published in Angewandte Chemie, International Edition in 2019. Application In Synthesis of 2-Bromo-5-methylpyridine The author mentioned the following in the article:

A unique concept for the intermol. denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Application In Synthesis of 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Application In Synthesis of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C6H6BrNIn 2022 ,《Anion-Directed Regulation of Structures and Luminescence of Heterometallic Clusters》 appeared in Angewandte Chemie, International Edition. The author of the article were Li, Jiao-Jiao; Liu, Chun-Yu; Guan, Zong-Jie; Lei, Zhen; Wang, Quan-Ming. The article conveys some information:

Anions have been used to regulate the structures and luminescence of heterometallic clusters. Introducing ClO4- into orange-emissive, butterfly-like [(C)(Au-PPhpy2)6Ag4](BF4)6 (1, PPhpy2 = bis(2-pyridyl)phenylphosphine) leads to the formation of red-emissive [(C)(Au-PPhpy2)6Ag5(ClO4)3](ClO4)4 (2) with a novel trigonal bipyramidal structure; employing PhCO2- gives yellow-emissive, hexagram-like [(C)(Au-PPhpy2)6Ag6(PhCO2)3](BF4)5 (3). Notably, 1 exhibits weak luminescence in CH2Cl2/CH3OH = 1 : 1 (v : v) with a quantum yield (QY) of 0.05, whereas it was dramatically increased to 0.49 and 0.83 for 2 and 3, resp. Theor. calculation confirms that the involvement of anions in the electronic structures is responsible for the shifts of emission. The high QYs of 2 and 3 are attributed to the protection provided by ligands and anions. This work demonstrates that anions may serve as an extra designable factor beyond just counterions for functional metal clusters. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Computed Properties of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Merging C-H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis》 was written by Jiang, Xunjin; Zeng, Zhixiong; Hua, Yuhui; Xu, Beibei; Shen, Yang; Xiong, Jing; Qiu, Huijuan; Wu, Yifan; Hu, Tianhui; Zhang, Yandong. Electric Literature of C6H6BrNThis research focused onvinyl arylpyridine regioselective vinylation photochem aza electrocyclization anticancer DFT; dihydropyridoisoquinolinium preparation; dihydrobenzoquinoline preparation. The article conveys some information:

Pyridinium-containing polyheterocycles exhibit distinctive biol. properties and interesting electrochem. and optical properties and thus are widely used as drugs, functional materials, and photocatalysts. Here, we describe a unified two-step strategy by merging Rh-catalyzed C-H vinylation with two switchable electrocyclizations, including aza-6π-electrocyclization and all-carbon-6π-electrocyclization, for rapid and divergent access to dihydropyridoisoquinoliniums and dihydrobenzoquinolines. Through computation, the high selectivity of aza-electrocyclization in the presence of an appropriate “”HCl”” source under either thermal conditions or photochem. conditions is shown to result from the favorable kinetics and symmetries of frontier orbitals. We further demonstrated the value of this protocol by the synthesis of several complex pyridinium-containing polyheterocycles, including the two alkaloids berberine and chelerythrine. The experimental process involved the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Electric Literature of C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Electric Literature of C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Suzuki, Hirotsugu; Liao, Yumeng; Kawai, Yuya; Matsuda, Takanori published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Rhodium-Catalyzed Additive-Free C-H Ethoxycarbonylation of (Hetero)Arenes with Diethyl Dicarbonate as a CO Surrogate》.Name: 2-Bromo-5-methylpyridine The article contains the following contents:

A rhodium-catalyzed C(sp2)-H ethoxycarbonylation of indoles and arylpyridines using di-Et dicarbonate to form indole-2-carboxylic acid esters such as I [X = CH, N; R1 = H, 4-Me, 5-Cl, etc.] and isophthalates II [R2 = H, 5-Me, 5-Ph, etc.; R3 = H, 5-Me, 4-Me] was developed. The catalytic process featured an additive-free ethoxycarbonylation reaction, in which only ethanol and CO2 were produced as byproducts, providing a CO-free and operationally simple protocol. The introduced ethoxycarbonyl group was easily transformed into other ester and amide functionalities in a single step. Moreover, the reaction could be successfully applied on gram scale, and allowed for the efficient synthesis of indole-2-carboxylic acid esters and isophthalates. The experimental part of the paper was very detailed, including the reaction process of 2-Bromo-5-methylpyridine(cas: 3510-66-5Name: 2-Bromo-5-methylpyridine)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Name: 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Khatua, Hillol; Das, Sandip Kumar; Roy, Satyajit; Chattopadhyay, Buddhadeb published an article in 2021. The article was titled 《Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation》, and you may find the article in Angewandte Chemie, International Edition.Formula: C6H6BrN The information in the text is summarized as follows:

A general catalytic method using a Mn-porphyrin-based catalytic system is reported that enables two different reactions (click reaction and denitrogenative annulation) and affords two different classes of nitrogen heterocycles, 1,5-disubstituted 1,2,3-triazoles (with a pyridyl motif) and 1,2,4-triazolo-pyridines. Mechanistic studies suggest that although the click reaction likely proceeds through an ionic mechanism, which is different from the traditional click reaction, the denitrogenative annulation reaction likely proceeds via an electrophilic metallonitrene intermediate rather than a metalloradical intermediate. Collectively, this method is highly efficient and offers several advantages over other methods. For example, this method excludes a multi-step synthesis of the N-heterocyclic mols. described and produces only environmentally benign N2 gas a byproduct. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN)

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Chenhao; Gao, Anthony Z.; Nie, Xin; Ye, Chen-Xi; Ivlev, Sergei I.; Chen, Shuming; Meggers, Eric published their research in Journal of the American Chemical Society in 2021. The article was titled 《Catalytic α-Deracemization of Ketones Enabled by Photoredox Deprotonation and Enantioselective Protonation》.Category: pyridine-derivatives The article contains the following contents:

This study reports the catalytic deracemization of ketones bearing stereocenters in the α-position in a single reaction via deprotonation, followed by enantioselective protonation. The principle of microscopic reversibility, which has previously rendered this strategy elusive, is overcome by a photoredox deprotonation through single electron transfer and subsequent hydrogen atom transfer (HAT). Specifically, the irradiation of racemic pyridyl ketones in the presence of a single photocatalyst and a tertiary amine provides nonracemic carbonyl compounds with up to 97% enantiomeric excess. The photocatalyst harvests the visible light, induces the redox process, and is responsible for the asym. induction, while the amine serves as a single electron donor, HAT reagent, and proton source. This conceptually simple light-driven strategy of coupling a photoredox deprotonation with a stereocontrolled protonation, in conjunction with an enrichment process, serves as a blueprint for other deracemizations of ubiquitous carbonyl compounds In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Category: pyridine-derivatives) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem