Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35590-37-5, name is 5-Bromonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H3BrN2
To a degassed solution of 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan- 2-yl)aniline (1.0 equiv.), 5-bromonicotinonitrile (1.1 equiv.) and Na2CO3 (5 equiv., 2M aq. sln) was added PdCl2(dppf).CH2Cl2 adduct (0.15 equiv.). This mixture was heated to 120 C for 15 min in the microwave and cooled to room temperature. Water was added, the phases were separated and the water mixture was extracted with ethyl acetate. The organic phases were pooled, dried with MgSO4 and the volatiles removed in vacuo to give 5-(5-amino-2- methylphenyl)nicotinonitrile in 99% yield. LCMS (m/z) (M+H) = 210.0, Rt = 0.43 min.
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Reference:
Patent; NOVARTIS AG; BARSANTI, Paul Andrew; BURGER, Matthew T.; LOU, Yan; NISHIGUCHI, Gisele A.; POLYAKOV, Valery Rostislavovich; RAMURTHY, Savithri; SUBRAMANIAN, Sharadha; TAFT, Benjamin R.; TANNER, Huw Rowland; WAN, Lifeng; (180 pag.)WO2016/38583; (2016); A1;,
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