Category: 38186-82-2

Synthetic Route of 38186-82-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 38186-82-2 as follows.

6-Chloro-5-methylpyridin-3-amine (50 g, 0.352 mol, 1.0 eq) was dissolved in 6 mol/LIn a hydrochloric acid solution (500 mL), stir for 30 minutes, and cool to 0 C.A solution of sodium nitrite (29.1 g, 0.422 mol, 1.2 eq) in water (300 mL) was added dropwise.After the dropwise addition, the mixture was kept for 20 minutes, and returned to room temperature and stirred for 20 minutes.Then heated to 90 C for 30 minutes, LC-MS detection reaction is complete,The system was cooled to room temperature, extracted with EA (500 mL×5), and the organic phases were combined.It is dried, concentrated, and purified by silica gel column chromatography (100-200 mesh silica gel,PE: EA=15:1)The product was obtained as a white solid (17 g, yield: 34%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,38186-82-2, its application will become more common.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; (67 pag.)CN109810041; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 38186-82-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38186-82-2, name is 6-Chloro-5-methylpyridin-3-amine. A new synthetic method of this compound is introduced below.

2-Chloro-3-methyl-5-nitro-pyridine (2g, 11.6 mmol) and SnCl2No. (H2O)2 34.8 mmol) are refluxed in MeOH overnight. After cooled down, the mixture is diluted with ethyl acetate, washed with water, brine, dried over MgS04, concentrated and purified by column chromatography to afford 6-chloro-5-methyl-pyridin-3-ylamine (1.7g). To the solution of 6-chloro-5-methyl-pyridin-3-ylamine (1.7g, 11.6 mmol) in IN HCl is added the solution ofNaNOz (960mg, 13.92mmol) in water (10ml) slowly at 0 C. After the addition, the solution is stirred for 20min and then heated to 90 C for 30min. The solution is cooled down, quenched with K2C03, extracted with ether, dried over MgS04, and purified by column chromatography to afford the titled compound (560mg) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38186-82-2, 6-Chloro-5-methylpyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/123668; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem