Category: 39856-58-1

Salameh, Nihad published the artcileWaste-Minimized Continuous-Flow Synthesis of Oxindoles Exploiting a Polymer-Supported N Heterocyclic Palladium Carbene Complex in a CPME/Water Azeotrope, Computed Properties of 39856-58-1, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(11), 3766-3776, database is CAplus.

The development of an effective synthetic protocol for the synthesis of oxindoles in flow based on a C(sp³)-H activation process promoted by a supported N-heterocyclic carbene palladium heterogeneous catalytic system using cyclopentyl Me ether (CPME) as the reaction medium was reported. The design of the catalyst, the selection of the solvent medium, and the definition of a tailored continuous flow reactor have been all designed to establish an efficient waste-minimized process for the intramol. cyclization of N-methyl-2-halo-acetanilides. The use of CPME in its aqueous azeotropic mixture has allowed to reach high yields of products with a simplified precipitation workup that includes the downstream process separation and recycling of the solvent. An assessment of the environmental and safety hazard features has also been made in order to better clarify the implications in terms of sustainability of the newly developed process.

ACS Sustainable Chemistry & Engineering published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Computed Properties of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Recio, Javier published the artcileStudies on the preparation of aminobipyridines and bipyridine sultams via an intramolecular free radical pathway, Safety of 2-Bromopyridin-3-amine, the publication is RSC Advances (2020), 10(18), 10447-10451, database is CAplus and MEDLINE.

A variety of aminated bipyridines and bipyridine sultams are prepared by intramol. radical [1,5]-ipso and [1,6]-ortho substitutions, using a sulfonamide as a linker to connect the pyridyl radical to the pyridine under attack. For the cases studied, different regiochemistries were observed depending on the initial position of the sulfonamide linker.

RSC Advances published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dai, Jian-Jun published the artcileCopper-Promoted Sandmeyer Trifluoromethylation Reaction, HPLC of Formula: 39856-58-1, the publication is Journal of the American Chemical Society (2013), 135(23), 8436-8439, database is CAplus and MEDLINE.

A copper-promoted trifluoromethylation reaction of aromatic amines is described. This transformation proceeds smoothly under mild conditions and exhibits good tolerance of many synthetically relevant functional groups. It provides an alternative approach for the synthesis of trifluoromethylated arenes and heteroarenes. It also constitutes a new example of the Sandmeyer reaction.

Journal of the American Chemical Society published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, HPLC of Formula: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Deau, Emmanuel published the artcileMicrowave-assisted synthesis of novel N-(4-phenylthiazol-2-yl)-benzo[d]thiazole-, thiazolo[4,5-b]pyridine-, thiazolo[5,4-b]pyridine- and benzo[d]oxazole-2-carboximidamides inspired by marine topsentines and nortopsentines, Synthetic Route of 39856-58-1, the publication is Tetrahedron (2014), 70(35), 5532-5540, database is CAplus.

We report the synthesis of novel N-(4-phenylthiazol-2-yl)-substituted benzo[d]thiazole-, thiazolo[4,5-b]pyridine-, thiazolo[5,4-b]pyridine- and benzo[d]oxazole-2-carboximidamides, which were inspired by marine topsentines and nortopsentines. Condensation of 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) with various ortho-halogenated anilines, aminopyridines and aminophenols gave the corresponding aryliminodithiazoles in good to excellent yields. Copper(I)-mediated or nucleophilic-assisted cyclization of aryliminodithiazoles furnished cyano-functionalized benzo[d]thiazoles, thiazolo[4,5-b]- and thiazolo[5,4-b]-pyridines and benzo[d]oxazoles. The latter were condensed with substituted 4-phenylthiazol-2-amines to furnish twenty seven new polyaromatic carboximidamides in moderate to good yields.

Tetrahedron published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Synthetic Route of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Koovits, Paul J. published the artcileStructure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi, Name: 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(1), 126779, database is CAplus and MEDLINE.

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline’s recently disclosed open-resource “Chagas box” and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chem. efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bumagin, N. A. published the artcileEffecting heterogeneous catalysts on aluminum and silicon oxides, COA of Formula: C5H5BrN2, the publication is Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk (2015), 34-41, database is CAplus.

Convenient and technol. suitable methods for immobilization of palladium and 1,2-azole ligands on mesoporous aluminum and silicon oxides have been developed. The obtained palladium composites: Pd/Al2O3(60), Pd/Al2O3(90), Pd-L1/Al2O3(60), Pd-L2/SiO2(60) and L1PdCl2@SiO2 demonstrate high catalytic activity and recovery in the Suzuki reaction in aqueous media.

Vestsi Natsyyanal’nai Akademii Navuk Belarusi, Seryya Khimichnykh Navuk published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schenkel, Laurie B. published the artcileDiscovery of a biarylamide series of potent, state-dependent Na_V1.7 inhibitors, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(16), 3817-3824, database is CAplus and MEDLINE.

State-dependent Na_V1.7 inhibitors. The Na_V1.7 ion channel has garnered considerable attention as a target for the treatment of pain. Herein we detail the discovery and structure-activity relationships of a novel series of biaryl amides. Optimization led to the identification of several state-dependent, potent and metabolically stable inhibitors which demonstrated promising levels of selectivity over Na_V1.5 and good rat pharmacokinetics. Compound I, which demonstrated preferential inhibition of a slow inactivated state of Na_V1.7, was advanced into a rat formalin study where upon reaching unbound drug levels several fold over the rat Na_V1.7 IC₅₀ it failed to demonstrate a robust reduction in nociceptive behavior.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saget, Tanguy published the artcileEnantioselective C-H Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Angewandte Chemie, International Edition (2013), 52(30), 7865-7868, database is CAplus and MEDLINE.

Reported here is a new and mild enantioselective palladium(0)-catalyzed direct arylation to access highly functionalized and relevant dibenzazepinones possessing a quaternary stereocenter with excellent selectivities. The enantiodiscriminating CMD step occurs through a rare eight-membered palladacycle, which is unprecedented for an enantioselective process. With these substrates, a complete selectivity over competing C-H activations, which could give five- or six-membered rings, was found. Addnl. noteworthy features of the process are its good functional-group compatibility and the use of cheap and widely available taddol phosphoramidites as chiral ligands.

Angewandte Chemie, International Edition published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Schempp, Tabitha T. published the artcileA General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling, Name: 2-Bromopyridin-3-amine, the publication is Organic Letters (2017), 19(13), 3616-3619, database is CAplus and MEDLINE.

The preparation of substituted azaindolines utilizing a domino palladium-catalyzed Heck cyclization/Suzuki coupling is described. The approach is amenable for the construction of all four azaindoline isomers. A range of functional groups such as esters, amides, ketones, sulfones, amines, and nitriles are all tolerated under the reaction conditions.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vrijdag, Johannes L. published the artcileTowards New Tricyclic Motifs: Intramolecular C-H Arylation as the Key Step in a Formal [3+3] Cyclocondensation Strategy, Category: pyridine-derivatives, the publication is European Journal of Organic Chemistry (2017), 2017(11), 1465-1474, database is CAplus.

Tricyclic scaffolds structurally related to the well-known benzodiazepine class of drugs show diverse biol. activities strikingly different from those of their benzodiazepine counterparts. Interested by this scaffold-hopping perspective, we previously developed a continuous-flow method for the conversion of benzodiazepinediones into oxazoloquinolinones. Attempted extension of this synthetic route to the corresponding oxazolonaphthyridinone scaffolds met with limited success, however. This encouraged us to develop a different approach to pyridine-based tricyclic motifs. In line with our interest in scaffold hopping, in this paper authors describe a general, convergent [3+3] cyclocondensation approach to [1,3]oxazolo[4,5-c]-1-naphthyridin-4(5H)-ones. The key synthetic steps in this approach are: (1) the construction of an amide linkage connecting two peripheral heterocycles; and (2) a palladium-catalyzed intramol. C-H arylation to complete the tricyclic scaffold.

European Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C8H10O2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem