Related Products of 4021-07-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4021-07-2 as follows.
Weighing 3-methylpyridine-2-carboxylic acid (56.7 mg, 0.3 mmol), sodium hydroxide (16.0 mg, 0.15 mmol), TBAC (26.3 mg, 0.45 mmol), DTBP (165 muL, 0.9 mmol) into 25 mL of Schlenk 25 mL of Schlenk, Then CH3CN (0.5 mL) was added and placed in a 50 °C oil bath for 20 h. After completion of the reaction, the solvent was removed under reduced pressure and eluted with petroleum ether / ethyl acetate.The solvent was separated on a silica gel column, The yield of 2-chloro-3-methylpyridine was 70percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4021-07-2, its application will become more common.
Reference:
Patent; Dalian University of Technology; Feng Xiujuan; Zhang Xitao; Zhang Haixia; Bao Ming; (27 pag.)CN108586334; (2018); A;,
Pyridine – Wikipedia,
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