Category: 40296-46-6

Related Products of 40296-46-6 ,Some common heterocyclic compound, 40296-46-6, molecular formula is C8H7Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium hydroxide (40 mL, 6.25 M solution) was added to a stirred solution of 4,6-dichloronicotinic acid ethyl ester (22) (25.95 g, 118 mmol) in 4:1:1 THF:MeOH:water (600 mL). After 30 minutes, the reaction mixture was acidified to pH 2 with concentrated HCl, diluted with 1:1 EtOAc:Et2O and washed with water and brine. The organic layer was dried (Na2SO4) and concentrated. The resulting off-white solid was twice concentrated from toluene to give the desired product (23) as a white solid (21.73 g, 96%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 40296-46-6, Ethyl 4,6-dichloronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wallace, Eli; Hurley, Brian; Yang, Hon Woon; Lyssikatos, Joseph; Blake, Jim; US2005/49419; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.40296-46-6, name is Ethyl 4,6-dichloronicotinate, molecular formula is C8H7Cl2NO2, molecular weight is 220.0527, as common compound, the synthetic route is as follows.Product Details of 40296-46-6

Example IX Preparation of [(4,6-dichloropyridin-3-yl)methyl](methyl)-oxido lambda4-sulfanylidenecyanamide (9) To a stirred solution of ethyl 4,6-dichloronicotinate (8.8 g, 40 mmol) in anhydrous THF (75 mL) cooled in an ice-water bath was added in a dropwise fashion 1 M LiAlH4 solution in THF (25 mL, 25 mmol). During the addition, the temperature was not allowed to rise above 25 C. After the addition was over, the reaction was warmed to 40 C. for 15 min, cooled, then quenched by the successive dropwise addition of water (0.95 mL), 15% aqueous NaOH (0.95 mL) and water (1.85 mL). The mixture was filtered through celite and the filtrated was dried (MgSO4), passed through a short pad of silica gel and concentrated to give a red oil. Ether (100 mL) was added whereupon a gummy precipitate immediately appeared, which was removed by filtration. The ether solution was allowed to stand at room temperature overnight, during which time more precipitate was formed which was removed again by filtration. The ether solution was concentrated and dried to give 3.25 g of the product 2,4-dichloro-5-hydroxy-methylpyridine in 46% yield as a nearly colorless oily solid. 1H NMR (300 MHz, CDCl3) delta 8.5 (s, 1H), 7.4 (s, 1H), 4.8 (s, 2H), 2.7 (bs, 1H); GC-MS: mass calcd for C6H5Cl2NO [M]+, 177. Found

At the same time, in my other blogs, there are other synthetic methods of this type of compound,40296-46-6, Ethyl 4,6-dichloronicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B.; US2008/108667; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem