Category: 500-22-1

Authors Yu, L; Lv, LY; Qiu, ZH; Chen, ZP; Tan, Z; Liang, YF; Li, CJ in WILEY-V C H VERLAG GMBH published article about C-H BONDS; OLEFIN SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; ALDEHYDES; ALKENYLATION; CARBANIONS; 1,3-DIENES; ALCOHOLS; ALKENES in [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Tan, Ze] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China in 2020.0, Cited 62.0. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

We have developed an unprecedented Pd-catalyzed formal hydroalkylation of alkynes with hydrazones, which are generated in situ from naturally abundant aldehydes, as both alkylation reagents and hydrogen donors. The hydroalkylation proceeds with high regio- and stereoselectivity to form (Z)-alkenes, which are more difficult to generate compared to (E)-alkenes. The reaction is compatible with a wide range of functional groups, including hydroxy, ester, ketone, nitrile, boronic ester, amine, and halide groups. Furthermore, late-stage modifications of natural products and pharmaceutical derivatives exemplify its unique chemoselectivity, regioselectivity, and synthetic applicability. Mechanistic studies indicate the possible involvement of Pd-hydride intermediates.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 BIOORGAN MED CHEM published article about TRANSITION-STATE ANALOG; CRYSTAL-STRUCTURE; HYDROXY COMPOUNDS; DERIVATIVES; PYRROLIDINE; BINDING; PHOSPHORYLATION; ENANTIOMERS; MECHANISM; ALCOHOLS in [Claret, Eduard Mas; Al Yahyaei, Balqees; Chu, Shuyu; Imperato, Manuel; Lopez, Arnaud; Howlin, Brendan J.; Whelligan, Daniel K.] Univ Surrey, Dept Chem, Guildford GU2 7XH, Surrey, England; [Elliott, Ruan M.] Univ Surrey, Dept Nutr Sci, Sch Biosci & Med, Guildford GU2 7XH, Surrey, England; [Meira, Lisiane B.] Univ Surrey, Dept Clin & Expt Med, Sch Biosci & Med, Guildford GU2 7XH, Surrey, England in 2020.0, Cited 66.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Generation of a Heteropolycyclic and sp(3)-Rich Scaffold for Library Synthesis from a Highly Diastereoselective Petasis/Diels-Alder and ROM-RCM Reaction Sequence WOS:000458273900021 published article about DIVERSITY-ORIENTED SYNTHESIS; CHEMICAL SPACE; CYCLIZATION; ACID; DRUG; METATHESIS; COMPLEXITY; MITSUNOBU; ESTERS in [Flagstad, Thomas; Azevedo, Carlos M. G.; Troelsen, Nikolaj S.] Tech Univ Denmark, Dept Chem, Ctr Nanomed & Theranost, Kemitorvet 207, DK-2800 Lyngby, Denmark; EDELRIS, 115 Ave Lacassagne, F-69003 Lyon, France; Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 637551, Singapore; Univ Copenhagen, Dept Immunol & Microbiol, Costerton Biofilm Ctr, DK-2200 Copenhagen, Denmark in 2019.0, Cited 43.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A-C) from a single precursor, which in turn is available through a one-pot Petasis 3-component reaction/Diels-Alder cascade reaction. We demonstrate the versatility of the approach through the synthesis of 35 exemplary compounds from the three classes, as well as by the production of 2188 final compounds, which have been included in the Joint European Compound Library of the European Lead Factory.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 CHEM-EUR J published article about FRIEDEL-CRAFTS REACTIONS; PI-ACTIVATED ALCOHOLS; NUCLEOPHILIC-SUBSTITUTION; ALLYLIC ALCOHOLS; MILD; MITSUNOBU; DERIVATIVES; AMINATION; TRIFLATE; AMINES in [Estopina-Duran, Susana; Donnelly, Liam J.; Mclean, Euan B.; Hockin, Bryony M.; Slawin, Alexandra M. Z.; Taylor, James E.] Univ St Andrews, EaStCHEM, Sch Chem, St Andrews KY16 9ST, Fife, Scotland; [Taylor, James E.] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England in 2019.0, Cited 58.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C-O bonds. This method has been applied to the intermolecular substitution of benzylic alcohols to form symmetrical ethers, intramolecular cyclisations of diols to form aryl-substituted tetrahydrofuran and tetrahydropyran derivatives, and intermolecular crossed-etherification reactions between two different alcohols. Mechanistic control experiments have identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about ACRIDINE-DERIVATIVES; ANTIOXIDANT; POTENT; AGENTS, Saw an article supported by the All India Council for Technical Education, New Delhi [8023/RiD/RPS-30/2010-11]. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Kalirajan, R; Gaurav, K; Pandiselvi, A; Gowramma, B; Sankar, S. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Recommanded Product: 3-Pyridinecarboxaldehyde

Background: 9-anilinoacridines are acting as DNA-intercalating agents which plays an important role as antitumor drugs, due to their anti-proliferative properties. Some anticancer agents contain 9-anilinoacridines such as amsacrine (m-AMSA), and nitracrine (Ledakrine) have been already developed. Methods: In this study, novel 9-anilinoacridines substituted with thiazines 4a-r were designed, synthesized, characterized by physical and spectral data and their cytotoxic activities against DLA cell lines were evaluated. Results: Among those compounds, 4b, c, e, g, i, j, k, m, o, p, q, r exhibited significant short term in vitro cytotoxic activity against Daltons lymphoma ascites (DLA) cells with CTC50 value of 0.18 to 0.31 mu M. The compounds 4b, c, e, g, y j, k, m, o, p, q, r are also exhibited significant long term in vitro anti-tumour activity against human tumor cell lines, HEp-2 (laryngeal epithelial carcinoma) by Sulforhodamine B assay with CTC50 value of 0.20 to 0.39 mu M. The compounds 4b, i, j exhibited significant in vivo antitumor activity with % Increase in Life Span (ILS) 48-82%. Conclusion: Results obtained in this study clearly demonstrated that many of the thiazine substituted 9-anilinoacridines exert interesting anti-tumour activity. The compounds 4b, i, j have significant anti-tumour activity and useful drugs after further refinement. The above derivatives will encourage to design future antitumor agents with high therapeutic potentials.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis and biological evaluation of 2,2-dimethylbenzopyran derivatives as potent neuroprotection agents WOS:000457379300022 published article about SUPEROXIDE-DISMUTASE; IN-VITRO; STROKE; ISCHEMIA; MUTANT; MICE in [Du, Fangyu; Zhou, Qifan; Shi, Yajie; Chen, Yuanguang; Fang, Wuhong; Chen, Guoliang] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Fu, Xiaoxiao; Yang, Jingyu] Shenyang Pharmaceut Univ, Dept Pharmacol, Shenyang 110016, Peoples R China in 2019.0, Cited 34.0. Computed Properties of C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The development of novel neuroprotection agents is of great significance for the treatment of ischemic stroke. In this study, a series of compounds comprising 2,2-dimethylbenzopyran groups and cinnamic acid groups have been synthesized. Preferential combination principles and bioisostere that improved the neuroprotective effect of the compounds were identified for this series via biological activity assay in vitro. Meanwhile, a functional reversal group of the acrylamide amide resulted in the most active compounds. Among them, BN-07 significantly improved the morphology of neurons and obviously increased cell survival rate of primary neurons induced by oxygen glucose deprivation (OGD), superior to clinically used anti-ischemic stroke drug edaravone (Eda). Overall, our findings may provide an alternative strategy for the design of novel anti-ischemic stroke agents with more potency than Eda.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry published in 2019.0. Application In Synthesis of 3-Pyridinecarboxaldehyde, Reprint Addresses Hirsch, AKH (corresponding author), Univ Groningen, Stratingh Inst Chem, Nijenborgh 7, NL-9747 AG Groningen, Netherlands.; Dekker, FJ (corresponding author), Univ Groningen, GRIP, Chem & Pharmaceut Biol, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands.; Hirsch, AKH (corresponding author), Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, Dept Drug Design & Optimizat, Campus Bldg E8-1, DE-66123 Saarbrucken, Germany.; Hirsch, AKH (corresponding author), Saarland Univ, Dept Pharm, DE-66123 Saarbrucken, Germany.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Recent studies have shown that 15-LOX-1 plays an important role in physiological processes linked to several diseases such as airway inflammation disease, coronary artery disease, and several types of cancer such as rectal, colon, breast and prostate cancer. In this study, we aimed to extend the structural diversity of 15-LOX-1 inhibitors, starting from the recently identified indolyl core. In order to find new scaffolds, we employed a combinatorial approach using various aromatic aldehydes and an aliphatic hydrazide tail. This scaffold-hopping study resulted in the identification of the 3-pyridylring as a suitable replacement of the indolyl core with an inhibitory activity in the micromolar range (IC50=16 +/- 6m) and a rapid and efficient structure-activity relationship investigation.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 500-22-1. Recently I am researching about NATURAL-PRODUCTS, Saw an article supported by the European Research Council under the European Union’s Horizon 2020 Research and Innovation ProgrammeEuropean Research Council (ERC) [714049]; Center for Molecular Biosciences (CMBI); German Academic Scholarship Foundation; German National Academy of Sciences Leopoldina; Tyrolean Science Fund (TWF) [F.16642/5-2019, UNI-0404/2354]; Austrian Science Fund (FWF)Austrian Science Fund (FWF) [M-2005]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Schmid, M; Sokol, KR; Wein, LA; Venegas, ST; Meisenbichler, C; Wurst, K; Podewitz, M; Magauer, T. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

We report our studies on the development of a catalytic cycloisomerization of 2,2-disubstituted neopentylic epoxides to produce highly substituted tetralins and chromanes. Termination of the sequence occurs via Friedel-Crafts-type alkylation of the remote (hetero)arene linker. The transformation is efficiently promoted by sulfuric acid and proceeds best in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) as the solvent. Variation of the substitution pattern provided detailed insights into the migration tendencies and revealed a competing disproportionation pathway of dihydronaphthalenes.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Haut, FL; Habiger, C; Speck, K; Wurst, K; Mayer, P; Korber, JN; Muller, T; Magauer, T in [Haut, Franz-Lucas; Habiger, Christoph; Muller, Thomas; Magauer, Thomas] Leopold Franzens Univ Innsbruck, Inst Organ Chem, Innrain 80-82, A-6020 Innsbruck, Austria; [Haut, Franz-Lucas; Habiger, Christoph; Muller, Thomas; Magauer, Thomas] Leopold Franzens Univ Innsbruck, Ctr Mol Biosci, Innrain 80-82, A-6020 Innsbruck, Austria; [Speck, Klaus; Mayer, Peter; Korber, Johannes Nepomuk] Ludwig Maximilians Univ Munchen, Dept Chem & Pharm, Butenandtstr 5-13, D-81377 Munich, Germany; [Wurst, Klaus] Leopold Franzens Univ Innsbruck, Inst Gen Inorgan & Theoret Chem, Innrain 80-82, A-6020 Innsbruck, Austria published Synthetic Entry to Polyfunctionalized Molecules through the [3+2]-Cycloaddition of Thiocarbonyl Ylides in 2019.0, Cited 63.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Here we present a comprehensive study on the [3+2]-cycloaddition of thiocarbonyl ylides with a wide variety of alkenes and alkynes. The obtained dihydro- and tetrahydrothiophene products serve as exceptionally versatile intermediates providing access to thiophenes, dienes, dendralenes, and vic-quarternary carbon centers. The use of high-pressure conditions enables thermally unstable, sterically encumbered or moderately reactive substrates to undergo the cycloaddition under mild conditions, thereby increasing the yield by up to 58%. In addition, we showcase its utility by the formal syntheses of the pharmaceuticals NGB 4420 and tenilapine.

Category: pyridine-derivatives. Welcome to talk about 500-22-1, If you have any questions, you can contact Haut, FL; Habiger, C; Speck, K; Wurst, K; Mayer, P; Korber, JN; Muller, T; Magauer, T or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Manetti, D; Garifulina, A; Bartolucci, G; Bazzicalupi, C; Bellucci, C; Chiaramonte, N; Dei, S; Mannelli, LD; Ghelardini, C; Gratteri, P; Spirova, E; Shelukhina, I; Teodori, E; Varani, K; Tsetlin, V; Romanelli, MN in AMER CHEMICAL SOC published article about ACETYLCHOLINE-RECEPTORS; IN-VITRO; QUINOLINE DERIVATIVES; THERAPEUTIC TARGETS; LIGAND EFFICIENCY; FULL AGONIST; ALPHA-4-BETA-2; VARENICLINE; EPIBATIDINE; SUBTYPES in [Manetti, Dina; Bartolucci, Gianluca; Bellucci, Cristina; Chiaramonte, Niccolo; Dei, Silvia; Teodori, Elisabetta; Romanelli, Maria Novella] Univ Florence, Sect Pharmaceut & Nutraceut Sci, Dept Neurosci Psychol Drug Res & Childs Hlth NEUR, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Garifulina, Alexandra; Spirova, Ekaterina; Shelukhina, Irina; Tsetlin, Victor] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Dept Mol Basis Neurosignaling, Miklukho Maklaya St 16-10, Moscow 117997, Russia; [Bazzicalupi, Carla] Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 3, I-50019 Sesto Fiorentino, Italy; [Mannelli, Lorenzo Di Cesare; Ghelardini, Carla] Univ Florence, Sect Pharmacol & Toxicol, Dept NEUROFARBA, Viale G Pieraccini 6, I-50139 Florence, Italy; [Gratteri, Paola] Univ Firenze, Lab Mol Modeling Cheminformat, Dept NEUROFARBA, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Gratteri, Paola] Univ Firenze, QSAR, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Varani, Katia] Univ Ferrara, Inst Pharmacol, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy in 2019.0, Cited 64.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat cortex against [H-3]-cytisine and [3H]-methyllycaconitine to measure their affinity for alpha 4 beta 2* and alpha 7* nicotinic receptors. The new derivatives showed some preference for the alpha 4 beta 2* over the alpha 7* subtype, with their affinity being dependent on the endo/exo isomerism and on the methylation degree of the basic nitrogen. The endo primary amines displayed the lowest K-i values on both receptor subtypes. Selected compounds (1a, 2a, 3a, and 6a) were tested on heterologously expressed alpha 4 beta 2, alpha 7, and alpha 3 beta 2 receptors and on SHSY-5Y cells. Compounds 1a and 2a showed alpha 4 beta 2 antagonistic properties while behaved as full agonists on recombinant alpha 7 and on SHSYSY cells. On the alpha 3 beta 2 subtype, only the chloro derivative 2a showed full agonist activity and submicromolar potency (EC50 = 0.43 mu M). The primary amines described here represent new chemotypes for the alpha 7 and alpha 3* receptor subtypes.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem