Category: 500-22-1

An article New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors WOS:000496249500080 published article about DNA PHOSPHODIESTERASE 1; EMPIRICAL SCORING FUNCTIONS; PROTEIN-LIGAND DOCKING; BIOLOGICAL EVALUATION; IN-VITRO; THIOSEMICARBAZONES; TOPOISOMERASES; IDENTIFICATION; ANTICANCER; COMPLEXES in [Filimonov, Aleksander S.; Luzina, Olga A.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Lavrik, Olga, I] Russian Acad Sci, NN Vorozhtsov Novosibirsk Inst Organ Chem, Siberian Branch, 9 Akad Lavrentieva Ave, Novosibirsk 630090, Russia; [Chepanova, Arina A.; Zakharenko, Alexandra L.; Zakharova, Olga D.; Ilina, Ekaterina S.; Dyrkheeva, Nadezhda S.; Kuprushkin, Maxim S.] Russian Acad Sci, Novosibirsk Inst Chem Biol & Fundamental Med, Siberian Branch, 8 Akad Lavrentieva Ave, Novosibirsk 630090, Russia; [Filimonov, Aleksander S.; Volcho, Konstantin P.; Salakhutdinov, Nariman F.; Lavrik, Olga, I] Novosibirsk State Univ, Pirogova Str 1, Novosibirsk 630090, Russia; [Kolotaev, Anton, V; Khachatryan, Derenik S.] Natl Res Ctr, Fed State Unitary Enterprise, Inst Chem Reagents & High Pur Chem Subst, Kurchatov Inst, Moscow 107076, Russia; [Patel, Jinal; Leung, Ivanhoe K. H.; Chand, Raina; Ayine-Tora, Daniel M.] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand; [Reynisson, Johannes] Keele Univ, Sch Pharm & Bioengn, Hornbeam Bldg, Keele ST5 5BG, Staffs, England in 2019.0, Cited 61.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usnic acid derivatives with hydrazonothiazole pharmacophore moieties were synthesized and evaluated as Tdp1 inhibitors. Most of these compounds were found to be potent inhibitors with IC50 values in the low nanomolar range. The activity of the compounds was verified by binding experiments and supported by molecular modeling. The ability of the most effective inhibitors, used at non-toxic concentrations, to sensitize tumors to the anticancer drug topotecan was also demonstrated. The order of administration of the inhibitor and topotecan on their synergistic effect was studied, suggesting that prior or simultaneous introduction of the inhibitor with topotecan is the most effective.

Welcome to talk about 500-22-1, If you have any questions, you can contact Filimonov, AS; Chepanova, AA; Luzina, OA; Zakharenko, AL; Zakharova, OD; Ilina, ES; Dyrkheeva, NS; Kuprushkin, MS; Kolotaev, AV; Khachatryan, DS; Patel, J; Leung, IKH; Chand, R; Ayine-Tora, DM; Reynisson, J; Volcho, KP; Salakhutdinov, NF; Lavrik, OI or send Email.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 RES CHEM INTERMEDIAT published article about CIRCULAR-DICHROISM; CURCUMIN; ANTITUMOR; TOXICITY; ANALOGS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; CYTOTOXICITY; APOPTOSIS; DELIVERY; CELLS in [Huber, Imre; Perjesi, Pal] Univ Pecs, Dept Pharmaceut Chem, H-7624 Pecs, Hungary; [Zupko, Istvan; Gyovai, Andras] Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary; [Horvath, Peter; Kiss, Eszter] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary; [Gulyas-Fekete, Gergely; Schmidt, Janos] Univ Pecs, Dept Biochem & Med Chem, H-7624 Pecs, Hungary in 2019.0, Cited 50.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

A new series (6) of C-5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is described here with their evaluation for in vitro antiproliferative activities. Evaluation of 31 compounds against human A2780 (ovarian), C33A (cervix) and MDA-MB-231 (breast) cancer cell lines was performed to obtain structure activity relation data. The best performer was (2E,6E)-2,6-bis(3 ‘-nitrobenzylidene)-4-hydroxycyclohexanone (6h) with IC50 values of 0.68 mu M (A2780), 0.69 mu M (C33A) and 0.92 mu M (MDA-MB-231) compared to cisplatin with 1.30 mu M, 3.69 mu M and 19.13 mu M, respectively. According to calculated physicochemical properties some members in series 6, namely (2E,6E)-2,6-bis[(4 ‘-pyridinyl)methylene]-4-hydroxycyclohexanone (6p) [IC50 = 0.76 mu M (A2780), 2.69 mu M (C33A), 1.28 mu M (MDA-MB-231)] seem to have improved bioavailability compared to curcumin. Selected members of series 6 were involved in circular dichroism spectroscopic measurements in order to determine their interaction with natural DNA. Based on these data, we conclude that these derivatives do not bind to DNA in vitro. A proposal is summarized based on mass spectrometric assessment for fingerprint analysis in biological research of such C-5-curcuminoids.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells published in 2019.0, Reprint Addresses Mullarky, E; Cantley, LC (corresponding author), Weill Cornell Med Coll, Meyer Canc Ctr, New York, NY 10065 USA.; Mullarky, E; Cantley, LC (corresponding author), Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there has been considerable interest in developing pharmacological agents to target this pathway. Here, we report a series of indole amides that inhibit human 3-phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first committed step of the serine synthesis pathway. Using X-ray crystallography, we show that the indole amides bind the NAD(+) pocket of PHGDH. Through structure-based optimization we were able to develop compounds with low nanomolar affinities for PHGDH in an enzymatic IC50 assay. In cellular assays, the most potent compounds inhibited de novo serine synthesis with low micromolar to sub-micromolar activities and these compounds successfully abrogated the proliferation of cancer cells in serine free media. The indole amide series reported here represent an important improvement over previously published PHGDH inhibitors as they are markedly more potent and their mechanism of action is better defined.

Name: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Mullarky, E; Xu, JY; Robin, AD; Huggins, DJ; Jennings, A; Noguchi, N; Olland, A; Lakshminarasimhan, D; Miller, M; Tomita, D; Michino, M; Su, TJF; Zhang, GA; Stamford, AW; Meinke, PT; Kargman, S; Cantley, LC or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 500-22-1. In 2020.0 GREEN CHEM published article about POT 4-COMPONENT SYNTHESIS; AEROBIC DEHYDROGENATION; FACILE SYNTHESIS; DERIVATIVES; ACID; FLUORESCENCE; PHENOLS; BINDING; DYES in [Mandal, Susanta; Chhetri, Karan; Bhuyan, Samuzal; Roy, Biswajit G.] Sikkim Univ, Dept Chem, 6th Mile, Gangtok 737102, Sikkim, India in 2020.0, Cited 67.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Acridines and acridinium ions are one of the important classes of compounds in terms of their usefulness in pharmaceuticals, materials, dyes and photo-catalysis. Here we present an unconventional FeCl3-alcohol catalysed one-pot method for their synthesis directly from aldehydes, 1,3-cyclohexanedione and amines. This method efficiently merged high atom-economy and diversity of multicomponent reaction with novel iron catalyzed dehydrogenation, using aerobic oxygen as the terminal oxidant, in alcoholic solvent to produce water as the only by-product. Easy scaling up of the method has been successfully demonstrated.

Welcome to talk about 500-22-1, If you have any questions, you can contact Mandal, S; Chhetri, K; Bhuyan, S; Roy, BG or send Email.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. Recently I am researching about SELECTIVE HYDROGENATION; EFFICIENT SYNTHESIS; FLUORENE; ARYLIDENEMALONODINITRILES; NANOPARTICLES; REDUCTION; CATALYSTS; ALCOHOLS; NITRO, Saw an article supported by the Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z704]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Yalcin, E; Duyar, H; Cakmaz, D; Sahin, E; Seferoglu, Z. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Novel 3-Amino-1-hetarylfluorene derivatives have medicinal uses and challenging transformation in organic synthesis have been synthesized via decyanation process. Surprisingly, the alkylated compounds derived from 3-Amino-1-hetarylfluorenes were obtained via further nucleophilic substitution to the 9-C and 3-N positions of the fluorene ring because of the harsh reaction condition employed. The synthesized compounds were characterized by spectroscopic techniques as well as X-ray single crystal diffraction analysis. This new family of blue emitting fluorene derivatives have low to moderate quantum yields (the largest value of Phi(F) = 0.52 for compound 15). (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 500-22-1, If you have any questions, you can contact Yalcin, E; Duyar, H; Cakmaz, D; Sahin, E; Seferoglu, Z or send Email.. Safety of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, Microwave-Assisted Synthesis and in Vitro Antibacterial and Antifungal Activity of 2,5-Disubstituted Benzimidazole published in 2019.0, Reprint Addresses Zhang, YM (corresponding author), Jilin Univ, Coll Chem, Changchun 130012, Jilin, Peoples R China.; Lin, F (corresponding author), Jilin Univ, Sch Life Sci, Changchun 130012, Jilin, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Seventeen novel 2,5-disubstituted benzimidazole derivatives were designed, synthesized and evaluated for their antibacterial activities. The tested compounds B1-B4 and C2-C6 exhibited not only good antifungal activity but also favorable broad-spectrum antibacterial activity. Also, the lowest MIC of antibacterial and antifungal activity was 2 mu g/mL and 4 mu g/mL, respectively. It suggested that the structure of compound including the different substituent and its sites directly affected the efficacy of the synthesized compounds.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019 ORG LETT published article about GRIGNARD-REAGENTS; STEREOSELECTIVE-SYNTHESIS; ARYL; ALKYL; PALLADIUM; HALIDES; COMPLEXES; CHLORIDES in [Lu, Xiao-Lin; Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Lu, Xiao-Lin; Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, State Key Lab Synthet Chem, Shatin, Hong Kong, Peoples R China; [Peng, Xiao-Shui; Wong, Henry N. C.] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen Municipal Key Lab Chem Synth Med Organ M, 10 Second Yuexing Rd, Shenzhen 518507, Peoples R China; [Shannon, Mark] Univ Warwick, Dept Chem, Gibbet Hill, Coventry CV4 7AL, W Midlands, England in 2019, Cited 38. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

An efficient synthetic protocol involving iron-catalyzed cross-coupling reactions between organolithium compounds and alkenyl iodides as key coupling partners was achieved. More than 30 examples were obtained with moderate to good yields and high stereospecificity. Gram scale and synthetic applications of this procedure are recorded herein to demonstrate its feasibility and potential utilization.

Welcome to talk about 500-22-1, If you have any questions, you can contact Lu, XL; Shannon, M; Peng, XS; Wong, HNC or send Email.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Pyridinecarboxaldehyde. In 2020.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; MOLECULAR-MECHANISMS; CINNAMALDEHYDE; DESIGN; REACTIVITY; INHIBITORS; TOXICITY in [Omar, Abdelsattar M.; El-Araby, Moustafa E.; Malebari, Azizah M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah 21589, Saudi Arabia; [Omar, Abdelsattar M.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11884, Egypt; [Abdelghany, Tamer M.; Abdel-Bakky, Mohamed S.] Al Azhar Univ, Fac Pharm, Dept Pharmacol, Cairo 11884, Egypt; [Safo, Martin K.; Ahmed, Mostafa H.] Virginia Commonwealth Univ, Dept Med Chem, Sch Pharm, Richmond, VA 23298 USA; [Safo, Martin K.; Ahmed, Mostafa H.] Virginia Commonwealth Univ, Inst Struct Biol Drug Discovery & Dev, Sch Pharm, Richmond, VA 23298 USA; [Boothello, Rio; Patel, Bhaumik B.] Virginia Commonwealth Univ, Dept Med, Div Hematol & Oncol, Richmond, VA 23298 USA; [Boothello, Rio; Patel, Bhaumik B.] Massey Canc Ctr, Richmond, VA 23298 USA; [Boothello, Rio; Patel, Bhaumik B.] Hunter Holmes McGuire VA Med Ctr, Richmond, VA 23249 USA; [Ahmed, Hany E. A.] Taibah Univ, Coll Pharm, Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawarah 47114, Saudi Arabia; [Ahmed, Hany E. A.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Cairo 11884, Egypt; [Elhaggar, Radwan S.] Helwan Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo 11790, Egypt in 2020.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Curcumin and trans-cinnamaldehyde are acrolein-based Michael acceptor compounds that are commonly found in domestic condiments, and known to cause cancer cell death via redox mechanisms. Based on the structural features of these compounds we designed and synthesized several 2-cinnamamido-N-substituted-cinnamamide (bis-cinnamamide) compounds. One of the derivatives, (Z)-2-[(E)-cinnamamido]-3-phenyl-N-propylacrylamide 8 showed a moderate antiproliferative potency (HCT-116 cell line inhibition of 32.0 mu M), no inhibition of normal cell lines C-166, and proven cellular activities leading to apoptosis. SAR studies led to more than 10-fold increase in activity. Our most promising compound, [(Z)-3-(1H-indol-3-yl)-N-propyl-2-[(E)-3-(thien-2-yl)propenamido) propenamide] 45 killed colon cancer cells at IC50 = 0.89 mu M (Caco-2), 2.85 mu M (HCT-116) and 1.65 mu M (HT -29), while exhibiting much weaker potency on C-166 and BHK normal cell lines (IC50 = 71 mu M and 77.6 mu M, respectively). Cellular studies towards identifying the compounds mechanism of cytotoxic activities revealed that apoptotic induction occurs in part as a result of oxidative stress. Importantly, the compounds showed inhibition of cancer stem cells that are critical for maintaining the potential for self-renewal and stemness. The results presented here show discovery of covalently acting Michael addition compounds that potently kill cancer cells by a defined mechanism, with prominent selectivity profile over non-cancerous cell lines.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis of Acrylamides via the Doebner-Knoevenagel Condensation published in 2019.0. HPLC of Formula: C6H5NO, Reprint Addresses Zacuto, MJ (corresponding author), Celgene Corp, Drug Subst Dev, 556 Morris Ave, Summit, NJ 07901 USA.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A selective synthesis of acrylamides had been developed using the Doebner-Knoevenagel condensation. The reaction occurs under mild conditions at ambient temperatures, tolerates a wide array of functional groups, and affords the E-isomer with high selectivity. The reported method expands the scope of this classic reaction to a class of industrially important products and as well as to the use of aliphatic aldehydes. An organocatalytic mechanism has been proposed, and the ability to scale the process has been demonstrated.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Organosuperbase dendron manganese complex grafted on magnetic nanoparticles; heterogeneous catalyst for green and selective oxidation of ethylbenzene, cyclohexene and oximes by molecular oxygen WOS:000451791000010 published article about HIGHLY EFFICIENT CATALYSTS; AEROBIC OXIDATION; N-HYDROXYPHTHALIMIDE; FE3O4 NANOPARTICLES; CARBON NANOTUBES; AQUEOUS-SOLUTION; ONE-POT; COBALT; HYDROCARBONS; NANOCATALYST in [Faraji, Ali Reza; Ashouri, Fatemeh] Islamic Azad Univ IAUPS, Dept Appl Chem, Fac Pharmaceut Chem, Pharmaceut Sci Branch, Tehran, Iran; [Faraji, Ali Reza] Islamic Azad Univ IAUPS, Young Researchers & Elite Club, Pharmaceut Sci Branch, Tehran, Iran; [Hekmatian, Zahra] Payam Noor Univ, Dept Chem, Fac Sci, Hamadan, Iran; [Heydari, Somayyeh] Bu Ali Sina Univ, Fac Chem, POB 651783868, Hamadan, Iran; [Mosazadeh, Sima] Islamic Azad Univ IAUPS, Act Pharmaceut Ingredients Res Ctr, Pharmaceut Sci Branch, Tehran, Iran in 2019.0, Cited 60.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. COA of Formula: C6H5NO

Magnetic Fe3O4 nanoparticles as a support were modified with an amino-terminated organosilicon and cyanoric choloride ligands. The novel manganese complex was grafted on modified magnetic support (Mn(II)-Met@MMNPs). The nanocatalyst structure, particle size, morphology and surface properties was well characterized by elemental analysis, ICP-AES, MS, EDS, FT-IR, SEM, TEM, DLS, VSM, TGA, XRD and XPS. In order to develop an effective heterogeneous nanocatalyst for eco-friendly aerobic, highly active and selective catalytic reactions, synthesized nanocatalyst was applied in oxidation of various organic compounds. The catalytic performance of the manganese nanocatalyst in the aerobic oxidation of ethylbenzene (EB), cyclohexene (CYHE) and various aldoximes and ketoxime were studied. Selective aerobic oxidation of EB and CYHE and various oximes were catalyzed by the Mn-nanocatalyst using N-hydroxyphthalimide (NHPI) with molecular oxygen as the green oxidant without the need of any reducing agent, and respectively the acetophenone (AcPO) as a benzylic product, 2-cyclohexene-1-one (CYHE=O) as an allylic product and corresponding carbonyl compounds were obtained. The oxidation process has been optimized for Mn-nanocatalyst by considering the effect of different parameters such as the ratio and amount of Mn-nanocatalystiNHPI, reaction time and solvent for achieving maximum conversion and selectivity to products. Due to their significant low cost, informal preparation, easy magnetically separation from reaction mixture, excellent catalytic performance, simple recovery and reusability without any metal leaching, the Mn-nanocatalyst has huge application prospect in selective and green oxidation process. (C) 2018 Published by Elsevier Ltd.

Welcome to talk about 500-22-1, If you have any questions, you can contact Faraji, AR; Ashouri, F; Hekmatian, Z; Heydari, S; Mosazadeh, S or send Email.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem