Category: 500-22-1

An article Structure-activity relationship study of DEL-22379: ERK dimerization inhibitors with increased safety WOS:000530794800002 published article about NUCLEAR TRANSLOCATION; DIMERS in [Yang, Yang; Zhou, Yuanzheng; Tao, Lei; Yang, Tao; Zhao, Yinglan; Luo, Youfu] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Sichuan, Peoples R China; [Yang, Yang; Zhou, Yuanzheng; Tao, Lei; Yang, Tao; Zhao, Yinglan; Luo, Youfu] Collaborat Innovat Ctr Biotherapy, Chengdu, Sichuan, Peoples R China; [Yang, Tao] Sichuan Univ, West China Hosp, Lab Human Dis & Immunotherapies, Chengdu, Sichuan, Peoples R China in 2021.0, Cited 15.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Aberrant activation of ERK signaling pathway usually leads to oncogenesis, and small molecular agents targeting this pathway are impeded by the emergence of drug resistance due to reactivation of ERK signaling. Compound DEL-22379 has been reported to inhibit ERK dimerization which was unaffected by drug-resistant mechanism reactivating the ERK signaling. Here, we discussed a structure-activity relationship study of DEL-22379. Forty-seven analogues were designed and synthesized. Each synthesized compound was biologically evaluated for their inhibitory rates on several tumor cell lines and compounds with high inhibitory rates were further evaluated for IC50 values. The structure-activity relationship of idolin-2-one scaffold and the impact of Z/E configuration on potency were discussed. Potential safety of two synthesized analogues was investigated and in silico docking study of five compounds was performed to understand the structural basis of ERK dimerization inhibition. [GRAPHICS] .

Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Yang, Y; Zhou, YZ; Tao, L; Yang, T; Zhao, YL; Luo, YF or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. In 2019.0 SYNLETT published article about ALDEHYDES; MECHANISM in [Matsukawa, Yuta; Hirashita, Tsunehisa] Nagoya Inst Technol, Grad Sch Engn, Life Sci & Appl Chem, Showa Ku, Gokiso Cho, Nagoya, Aichi 4668555, Japan in 2019.0, Cited 15.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A new aerobic oxidation system consisting of Cu(I)I, 2,2′-bipyridine, N-methyl imidazole, and a mesoionic hydroxyamide was developed, with which selective oxidation of a broad range of benzylic alcohols was achieved.

Welcome to talk about 500-22-1, If you have any questions, you can contact Matsukawa, Y; Hirashita, T or send Email.. Quality Control of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. Recently I am researching about ONE-POT SYNTHESIS; INDOLES, Saw an article supported by the . Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Jonnala, S; Nameta, B; Chavali, M; Bantu, R; Choudante, P; Misra, S; Sridhar, B; Dilip, S; Reddy, BVS. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A class of 1-((benzo[d]thiazol-2-ylamino)(phenyl)methyl)naphthalen-2-ol derivatives (4a-t) has been synthesized in good yields through a three component coupling reaction. The newly synthesized compounds were evaluated for their in vitro antiproliferative activity against five cell lines such as DU145 (human prostate cancer), MDA-MB-B231 (human breast cancer), SKOV3 (human ovarian cancer), B16-F10 (mouse skin melanoma) and CHO-K1 (Chinese hamster ovary cells), a non-cancerous cell line. In vitro inhibitory activity indicates that compounds 4a, 4b, 4c, 4d, 4g, 4j, and 4o exhibited potent anti-proliferative behavior. Among them, compounds 4g, 4j and 4o found to be the most active members exhibiting remarkable growth inhibitory activity. Molecular docking facilitates to investigate the probable binding mode and key active site interactions in tubulins alpha and beta proteins. The docking results are complementary to experimental results.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. I found the field of Chemistry very interesting. Saw the article Carbene-catalyzed oxidative acylation promoted by an unprecedented oxidant CCl3CN published in 2019.0, Reprint Addresses Wang, J (corresponding author), Tsinghua Univ, Minist Educ, Sch Pharmaceut Sci, Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

An unprecedented example of a NHC-catalyzed acylation reaction promoted by an oxidant CCl3CN is described. This protocol features several advantages, including mild reaction conditions, broad substrate scope, and easy operation. In addition, low cost, low boiling point, and small molecular weight allow CCl3CN to be an attractive and amenable oxidant. Meanwhile, this formal dehydrogenative coupling reaction of aldehydes and alcohols involves a hydride transfer process.

Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. In 2019.0 J AM CHEM SOC published article about CARBON QUATERNARY STEREOCENTERS; 6+3 CYCLOADDITION; MESO COMPOUNDS; GENERATION; CONSTRUCTION; PRESSURE; SULFUR; DENDRALENES; THIOPHENES; SULFONIUM in [Haut, Franz-Lucas; Habiger, Christoph; Muller, Thomas; Magauer, Thomas] Leopold Franzens Univ Innsbruck, Inst Organ Chem, Innrain 80-82, A-6020 Innsbruck, Austria; [Haut, Franz-Lucas; Habiger, Christoph; Muller, Thomas; Magauer, Thomas] Leopold Franzens Univ Innsbruck, Ctr Mol Biosci, Innrain 80-82, A-6020 Innsbruck, Austria; [Speck, Klaus; Mayer, Peter; Korber, Johannes Nepomuk] Ludwig Maximilians Univ Munchen, Dept Chem & Pharm, Butenandtstr 5-13, D-81377 Munich, Germany; [Wurst, Klaus] Leopold Franzens Univ Innsbruck, Inst Gen Inorgan & Theoret Chem, Innrain 80-82, A-6020 Innsbruck, Austria in 2019.0, Cited 63.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Here we present a comprehensive study on the [3+2]-cycloaddition of thiocarbonyl ylides with a wide variety of alkenes and alkynes. The obtained dihydro- and tetrahydrothiophene products serve as exceptionally versatile intermediates providing access to thiophenes, dienes, dendralenes, and vic-quarternary carbon centers. The use of high-pressure conditions enables thermally unstable, sterically encumbered or moderately reactive substrates to undergo the cycloaddition under mild conditions, thereby increasing the yield by up to 58%. In addition, we showcase its utility by the formal syntheses of the pharmaceuticals NGB 4420 and tenilapine.

Welcome to talk about 500-22-1, If you have any questions, you can contact Haut, FL; Habiger, C; Speck, K; Wurst, K; Mayer, P; Korber, JN; Muller, T; Magauer, T or send Email.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. In 2019.0 J NANOSTRUCT published article about ONE-POT SYNTHESIS; DERIVATIVES; INHIBITORS; ALDEHYDES; DESIGN in [Bamoniri, Abdolhamid; Yaghmaeiyan-Mahabadi, Nahid] Univ Kashan, Fac Chem, Dept Organ Chem, Kashan, Iran; [Mirjalili, Bi Bi Fatemeh] Yazd Univ, Coll Sci, Dept Chem, Yazd, Iran in 2019.0, Cited 43.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Kaolinite clay found its application in medicine, in toothpaste, in cosmetic and as a food additive. Recently, a specially formulated spray is used in fruit and vegetable production to repel the insects and prevent sunburn. Kaolin-SO3H nanoparticles were prepared via reaction of kaolin and chlorosulfonic acid and characterized by FT-IR, XRD, FESEM, TEM, XRF, EDS, BET and TGA. 2-Substituted benzimidazoles have been used as selective neuropeptides YY, receptor antagonists, antitumor, antivirus, antimicrobial, antioxidant, antiparasitic, antihelmintics, antiproliferative, anti-HIV, anticonvulsant, anti-inflammatory, antihypertensive, antineoplastic, analgesicand antitrichinellosis, topoisomerase IV inhibitors, potent inhibitors of TiE-2 and VEGFER-2 tyrosine kinase receptor, and 5-HT3 antagonists. 2-Substituted benzimidazoles are prepared via condensation of o-phenylenediamines and aldehydes. In this article, we have used Kaolin-SO3H nanoparticles for the synthesis of 2-substituted benzimidazoles under mild reaction conditions. The structure of products were identified by FT-IR, H-1-NMR and C-13-NMR. This method has the advantages of high yields, short reaction times and easy work-up.

Computed Properties of C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Bamoniri, A; Mirjalili, BBF; Yaghmaeiyan-Mahabadi, N or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 ANGEW CHEM INT EDIT published article about ALDOL CONDENSATION SYNTHESIS; AXIALLY CHIRAL BIARYLS; ENANTIOSELECTIVE SYNTHESIS; KINETIC RESOLUTION; NATURAL-PRODUCTS; CONSTRUCTION; ATROPISOMERS; ALDEHYDES; OXIDATION; ARYLATION in [Xu, Ke; Li, Wenchang; Zhu, Shaoheng; Zhu, Tingshun] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China in 2019.0, Cited 146.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

Atroposelective arene formation is an efficient method to build axially chiral molecules with multi-substituted arenes. Reported here is an organocatalyzed atroposelective arene formation reaction by an N-heterocyclic carbene (NHC) catalyzed formal [4+2] cycloaddition of conjugated dienals and alpha-aryl ketones. This study expands the synthetic potential of NHC organocatalysis and provides a competitive pathway for the synthesis of axially chiral ligands, catalysts, and other functional molecules.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Xu, K; Li, WC; Zhu, SH; Zhu, TS or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Li, YX; Chen, YG; Yu, ZF; Yang, XF; Nie, Y; Cui, Y; Sun, GX in AMER CHEMICAL SOC published article about AGGREGATION-INDUCED EMISSION; FLUORESCENCE; DERIVATIVES; MECHANOCHROMISM; LUMINESCENCE; ISOMERS; COLOR in [Li, Ye-Xin; Chen, You-Gui; Yu, Zhen-Feng; Yang, Xiao-Feng; Nie, Yong; Cui, Yu; Sun, Guo-Xin] Jinan Univ, Sch Chem & Chem Engn, Jinan 250022, Peoples R China in 2020.0, Cited 31.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The mechanism of most mechanofluorochromic (MFC) materials is related to a noncovalent change in aggregate packing. It is still a challenge to clarify the respective effects of molecular conformation and intermolecular interaction on the MFC performance. Herein, a new (9-anthryl)vinyl derivative APYB with a polymorph-dependent multicolor-switchable MFC property is reported. APYB has only one torsion unit in the molecule configuration and could form four different crystal phases (APYB-a, APYB-b, APYB-c, and APYB-d). Furthermore, all polymorphs are MFC-active. Therefore, it provides a rare and direct case to correlate the aggregate packing with MFC performance. The solid-state emission could be finely tuned from 465 to 500 nm by virtue of polymorphism. Crystal structure analyses and optical studies reveal that an increasing twist angle could result in a blue shift in the fluorescence spectrum and a high-contrast MFC performance. In contrast, strong intermolecular interactions could lead to high emission efficiency and amorphization difficulty during the mechanical grinding. A tricolor-switchable MFC phenomenon was observed for APYB-a, while both APYB-b and APYB-d display a reversible bicolor-changing MFC behavior. As for APYB-c, mechanical grinding only causes a minor change in the emission spectrum. However, two competitive reverse transformation routes were found when treating the ground sample with organic solvent vapor. XRD analyses show that the MFC mechanism for APYB-a, APYB-c, and APYB-d is a crystal-to-amorphous transformation, while only partial amorphization was observed in the MFC behavior of APYB-b. The acidochromism effects of APYB-a and APYB-b were also investigated. They also display multicolor changes due to the polymorphic nature of APYB. Interestingly, in the deprotonation process, NH3 vapor could induce a different transformation route and color change from NEt3.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. Authors Gunawardene, PN; Luo, W; Polgar, AM; Corrigan, JF; Workentin, MS in AMER CHEMICAL SOC published article about in [Workentin, Mark S.] Univ Western Ontario, Dept Chem, Richmond St, London, ON N6A 5B7, Canada; Univ Western Ontario, Ctr Mat & Biomat Res, Richmond St, London, ON N6A 5B7, Canada in 2019, Cited 25. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Highly accelerated inverse-electron-demand strain-promoted alkyne-nitrone cycloaddition (IED SPANC) between a stable cyclooctyne (bicyclo[6.1.0]nonyne (BCN)) and nitrones delocalized into a C-a-pyridinium functionality is reported, with the most electron-deficient pyridinium-nitrone displaying among the most rapid cycloadditions to BCN that is currently reported. Density functional theory (DFT) and X-ray crystallography are explored to rationalize the effects of N- and C-a-substituent modifications at the nitrone on IED SPANC reaction kinetics and the overall rapid reactivity of pyridinium-delocalized nitrones.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about CIRCULAR-DICHROISM; CURCUMIN; ANTITUMOR; TOXICITY; ANALOGS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; CYTOTOXICITY; APOPTOSIS; DELIVERY; CELLS, Saw an article supported by the University of Pecs (PTE); University of Pecs, Faculty of Medicine Research Fund [PTE AOK-KA-34039-12/10-11]. Category: pyridine-derivatives. Published in SPRINGER in DORDRECHT ,Authors: Huber, I; Zupko, I; Gyovai, A; Horvath, P; Kiss, E; Gulyas-Fekete, G; Schmidt, J; Perjesi, P. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A new series (6) of C-5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is described here with their evaluation for in vitro antiproliferative activities. Evaluation of 31 compounds against human A2780 (ovarian), C33A (cervix) and MDA-MB-231 (breast) cancer cell lines was performed to obtain structure activity relation data. The best performer was (2E,6E)-2,6-bis(3 ‘-nitrobenzylidene)-4-hydroxycyclohexanone (6h) with IC50 values of 0.68 mu M (A2780), 0.69 mu M (C33A) and 0.92 mu M (MDA-MB-231) compared to cisplatin with 1.30 mu M, 3.69 mu M and 19.13 mu M, respectively. According to calculated physicochemical properties some members in series 6, namely (2E,6E)-2,6-bis[(4 ‘-pyridinyl)methylene]-4-hydroxycyclohexanone (6p) [IC50 = 0.76 mu M (A2780), 2.69 mu M (C33A), 1.28 mu M (MDA-MB-231)] seem to have improved bioavailability compared to curcumin. Selected members of series 6 were involved in circular dichroism spectroscopic measurements in order to determine their interaction with natural DNA. Based on these data, we conclude that these derivatives do not bind to DNA in vitro. A proposal is summarized based on mass spectrometric assessment for fingerprint analysis in biological research of such C-5-curcuminoids.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Huber, I; Zupko, I; Gyovai, A; Horvath, P; Kiss, E; Gulyas-Fekete, G; Schmidt, J; Perjesi, P or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem