Category: 500-22-1

Recently I am researching about MULTICOMPONENT REACTIONS; CONVERTIBLE ISOCYANIDE; RAPID ACCESS; CONDENSATION, Saw an article supported by the CONACYTConsejo Nacional de Ciencia y Tecnologia (CONACyT) [632715/338546, 285622 CB-2016-28562]; Laboratorio Nacional de Caracterizacion de Propiedades Fisicoquimicas y Estructura Molecular (CONACYT-Mexico) [123732]; ENSTA Paris. Product Details of 500-22-1. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The Ugi reaction of 2-nitrobenzoic acid derivatives has been used for a diversity oriented synthesis of complex isoindolinones via a SNAr reaction involving the peptidyl position. When the cyclization is triggered by strong bases such as potassium tert-butylate, the SNAr reaction is followed by a deamidification/oxidation sequence leading to 2-hydroxyisoindolinones. The latter may be further transformed into polycyclic fused isoindolinones via Pictet-Spengler type cyclization or O-alkylation/metathesis sequences.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kurva, M; Kerim, MD; Gamez-Montano, R; El Kaim, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Discovery of BAY-298 and BAY-899: Tetrahydro-1,6-naphthyridine-Based, Potent, and Selective Antagonists of the Luteinizing Hormone Receptor Which Reduce Sex Hormone Levels in Vivo WOS:000500420100020 published article about GONADOTROPIN; EXPRESSION; OVARIAN; CELLS; PATHOGENESIS; SOLUBILITY; INHIBITORS; GENE in [Wortmann, Lars; Lindenthal, Bernhard; Muhn, Peter; Walter, Alexander; Nubbemeyer, Reinhard; Heldmann, Dieter; Sobek, Lothar; Moosmayer, Dieter; Guenther, Judith; Kuhnke, Joachim; Koppitz, Marcus; Luecking, Ulrich; Roehn, Ulrike; Schaefer, Martina; Nowak-Reppel, Katrin; Weinmann, Hilmar; Langer, Gernot] Bayer AG, Res & Dev, Pharmaceut, D-13353 Berlin, Germany; [Morandi, Federica; Schrey, Anna K.; Kuehne, Ronald] Leibniz Forsch Inst Mol Pharmakol FMP, Robert Rossle Str 10,Campus Berlin Buch, D-13125 Berlin, Germany in 2019.0, Cited 56.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The human luteinizing hormone receptor (hLH-R) is a member of the glycoprotein hormone family of G-protein-coupled receptors (GPCRs), activated by luteinizing hormone (hLH) and essentially involved in the regulation of sex hormone production. Thus, hLH-R represents a valid target for the treatment of sex hormone dependent cancers and diseases (polycystic ovary syndrome, uterine fibroids, endometriosis) as well as contraception. Screening of the Bayer compound library led to the discovery of tetrahydrothienopyridine derivatives as novel, small molecule (SMOL) hLH-R inhibitors and to the development of BAY-298, the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo. Further optimization of physicochemical, pharmacokinetic, and safety parameters led to the identification of BAY-899 with an improved in vitro profile and proven efficacy in vivo. BAY-298 and BAY-899 serve as valuable tool compounds to study hLH-R signaling in vitro and to interfere with the production of sex hormones in vivo.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wortmann, L; Lindenthal, B; Muhn, P; Walter, A; Nubbemeyer, R; Heldmann, D; Sobek, L; Morandi, F; Schrey, AK; Moosmayer, D; Gunther, J; Kuhnke, J; Koppitz, M; Lucking, U; Rohn, U; Schafer, M; Nowak-Reppel, K; Kuhne, R; Weinmann, H; Langer, G or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Lin, SS; Zhang, LY; Zhang, X; Yu, ZL; Huang, XW; Xu, JH; Liu, Y; Chen, LM; Wu, LX in [Lin, Shanshan; Zhang, LingYu; Zhang, Xiao; Yu, Zelei; Huang, Xiuwang; Xu, Jianhua; Wu, Lixian] FMU, Sch Pharm, Dept Pharmacol, Fuzhou, Peoples R China; [Lin, Shanshan; Zhang, LingYu; Zhang, Xiao; Yu, Zelei; Xu, Jianhua; Liu, Yang; Chen, Limin; Wu, Lixian] FMU, Inst Mat Med, Fuzhou, Peoples R China; [Lin, Shanshan; Zhang, LingYu; Zhang, Xiao; Yu, Zelei; Huang, Xiuwang; Xu, Jianhua; Liu, Yang; Chen, Limin; Wu, Lixian] FMU, Fujian Key Lab Nat Med Pharmacol, Fuzhou, Peoples R China; [Huang, Xiuwang] FMU, Dept Publ Technol Serv Ctr, Fuzhou, Peoples R China; [Liu, Yang; Chen, Limin] FMU, Sch Pharm, Dept Pharmacochem, Fuzhou, Peoples R China published Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities in 2020.0, Cited 21.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Poly (ADP-ribose) polymerase (PARP) inhibitors have achieved great success in clinical application, especially for the prolonged survival of cisplatin-sensitive ovarian cancer patients. However, there are still many patients who do not respond to PARP inhibitors. Novel PARP inhibitors with higher activity are urgently needed. Herein we report a series of compounds by molecular hybridization PARP-1 inhibitor Olaparib (Ola) with HSP90 inhibitor C0817 (one curcumin derivative). All synthesized compounds were evaluated for their antiproliferative activity in vitro, and some were further assessed for their inhibitory activities of the PARP enzyme and HSP90 affinity. Our results indicated that compound 4 could bind to HSP90 and cause static quenching, indicating that compound 4 was able to bind to HSP90, moreover, downstream molecular breast cancer 1 (BRAC-1) was reduced. In conclusion, dual target inhibitors of PARP and HSP90 exhibited stronger selective cytotoxicities against cancer.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Lin, SS; Zhang, LY; Zhang, X; Yu, ZL; Huang, XW; Xu, JH; Liu, Y; Chen, LM; Wu, LX or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 3-Pyridinecarboxaldehyde. Recently I am researching about UNACTIVATED ALKYL-HALIDES; GRIGNARD-TYPE ADDITION; C-H BONDS; CARBONYL-COMPOUNDS; ORGANIC-REACTIONS; ALPHA,BETA-UNSATURATED KETONES; QUATERNARY CENTERS; IN-SITU; ORGANOINDIUM REAGENTS; ASYMMETRIC-SYNTHESIS, Saw an article supported by the Nanjing Tech University [39837118]; Yancheng Teachers University; Nanjing Forestry University. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Wu, Z; Feng, XX; Wang, QD; Liu, XY; Rao, WD; Yang, JM; Shen, ZL. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

An efficient water-based bismuth-mediated addition reaction of carbonyl compound with cyclic allylic halide was developed. The reactions proceeded smoothly in aqueous DMF in the presence of ammonium iodide to afford the corresponding syn-homoallylic alcohols in moderate to good yields with excellent diastereoselectivities (>99:1 syn:anti). Reversal of product diastereoselectivity was observed when heteroaryl aldehyde possessing an adjacent chelating nitrogen atom was employed as substrate. 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Recommanded Product: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wu, Z; Feng, XX; Wang, QD; Liu, XY; Rao, WD; Yang, JM; Shen, ZL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Imidazo[1,2-a]pyridine A(3)-Coupling Catalyzed by a Cu/SiO2 Material WOS:000482836400005 published article about ONE-POT SYNTHESIS; 3-COMPONENT COUPLING REACTION; MULTICOMPONENT SYNTHESIS; COPPER; ALKYNE; 2-AMINOPYRIDINES; CYCLOADDITION; CYCLIZATION; PALLADIUM; ALDEHYDES in [de Salles, Helena D.; Benvenutti, Edilson, V; Schneider, Paulo H.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil; [da Silva, Tiago L.] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149,Bloco A, BR-21941909 Rio de Janeiro, RJ, Brazil; [Radatz, Catia S.] Univ Fed Pelotas UFPeI, CCQFA, BR-96010900 Pelotas, RS, Brazil; [Affeldt, Ricardo F.] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil in 2019.0, Cited 60.0. HPLC of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A(3)-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%). which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of reaction intermediates inside the pores of the mesoporous material prior to 5-exo-dig cyclization.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact de Salles, HD; da Silva, TL; Radatz, CS; Affeldt, RF; Benvenutti, EV; Schneider, PH or concate me.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Teng, QQ; Ng, PS; Leung, JN; Huynh, HV in [Teng, Qiaoqiao; Ng, Ping Siang; Leung, Jia Nuo; Han Vinh Huynh] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore; [Teng, Qiaoqiao] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China published Donor Strengths Determination of Pnictogen and Chalcogen Ligands by the Huynh Electronic Parameter and Its Correlation to Sigma Hammett Constants in 2019.0, Cited 37.0. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The suitability and accuracy of the Huynh electronic parameter (HEP) was further tested to reveal remote substituent effects in pyridines, which are located five or six bonds away from the reporter probe. These values show an excellent correlation to Hammett sigma-constants of the respective substituents with coefficients of R-2=0.9856 (sigma(m)) and R-2=0.9857 (sigma(p)). Based on this observation, a methodology for the re-evaluation of certain Hammett constants with larger uncertainties has been proposed and demonstrated. Moreover, the scope of HEP was extended to various neutral pnictogen and chalcogen donors during which transphobia effects were revealed for mixed NHC complexes containing phosphites, arsine and stibine for the first time.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Teng, QQ; Ng, PS; Leung, JN; Huynh, HV or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Ultralow Loading Cobalt-Based Nanocatalyst for Benign and Efficient Aerobic Oxidation of Allylic Alcohols and Biobased Olefins published in 2019.0. Recommanded Product: 500-22-1, Reprint Addresses Tao, DJ (corresponding author), Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China.; Li, CZ (corresponding author), Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The synthesis of alpha,beta-unsaturated ketones from aerobic oxidation of allylic alcohols and biobased olefins serves as an important topic in green and sustainable chemistry. In this work, we report the utilization of a sacrificial template ZIF-8 for preparation of mesoporous Co-0.05/N-C material with an ultralow cobalt loading of 0.05 wt %, in which the excellent catalytic performance in aerobic oxidation of alpha-pinene and cinnamyl alcohol was achieved with an 85% yield of verbenone and a yield of cinnamaldehyde, respectively. The results of control experiments and several characterization investigations further illustrate that the sacrificial template ZIF-8 plays a key role to disperse well metallic cobalt in the Co-0.05/N-C-800 catalyst and an appropriate cobalt content of 0.05 wt % is beneficial for benign and efficient aerobic oxidation of various allylic alcohols and biobased olefins. In addition, the Co0.05/N-C-800 catalyst also exhibited good stability and reusability for recovering and reusing at least six times without obvious decrease in catalytic activity. The presented efficient nanocatalyst thus triggers facile synthesis of a series of alpha,beta-unsaturated aldehydes/ketones in high yields.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhao, X; Zhou, Y; Huang, K; Li, CZ; Tao, DJ or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. I found the field of Chemistry very interesting. Saw the article Design and synthesis of novel sugar-based nitrogen-containing heterocycles as potential anticancer agents under microwave in water published in 2019.0, Reprint Addresses Du, K (corresponding author), Shaoxing Univ, Sch Chem & Chem Engn, Shaoxing 312000, Peoples R China.; Zheng, H (corresponding author), Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310016, Zhejiang, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A series of novel glycosyl nitrogen-containing heterocycles derivatives were designed and synthesized. With the help of microwave, the reaction was carried out in water rapidly and afforded the target compounds in good yields. The acid catalysts that were essential for this kind of reaction under traditional heating method were avoided through this strategy. Preliminary biological evaluation showed that most of the compounds could inhibit the growth of A549 cells, but the inhibition of HepG-2 cells was relatively poor. Notably, compound 2i displayed the best potency with an IC50 value of 3.42 mu M against A549 cell lines, which is comparable with the common anticarcinogen paclitaxel (5.12 mu M). Molecular modeling studies suggested that 2i may bind to the ATP-binding site of epidermal growth factor receptor (EGFR), indicating a rational design strategy. These results provide a starting point for designing glycosyl nitrogen-containing heterocycles as the potential drugs in lung cancer therapy.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Liu, J; Wu, CL; Jin, HM; Du, K; Zheng, H or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Driowya, M; Guillot, R; Bonnet, P; Guillaumet, G in [Driowya, Mohsine; Bonnet, Pascal; Guillaumet, Gerald] Univ Orleans, Inst Chim Organ & Analyt, UMR CNRS 7311, Orleans, France; [Guillot, Regis] Univ Paris Saclay, Univ Paris Sud, Inst Chim Mol & Mat Orsay, UMR CNRS 8182, Orsay, France published Development of Novel and Efficient Processes for the Synthesis of 5-Amino and 5-Iminoimidazo[1,2-a] imidazoles via Three-Component Reaction Catalyzed by Zirconium(IV) Chloride in 2019.0, Cited 48.0. Application In Synthesis of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

General and efficient approaches for the synthesis of new 5-amino and 5-iminoimidazo[1,2-a] imidazoles were developed through a three-component reaction of 1-unsubstituted 2-aminoimidazoles with various aldehydes and isocyanides mediated by zirconium(IV) chloride. The protocols were established considering the reactivity of the starting substrate, which varies depending on the presence of a substituent on the 2-aminoimidazole moiety. A library of new N-fused ring systems with wide structural diversification, novel synthetic, and potential pharmacological interest was obtained in moderate to good yields.

Application In Synthesis of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Driowya, M; Guillot, R; Bonnet, P; Guillaumet, G or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article High-Pressure-Mediated Thiourea-Organocatalyzed Asymmetric Michael Addition to (Hetero)aromatic Nitroolefins: Prediction of Reaction Parameters by PCP-SAFT Modelling WOS:000544057700023 published article about ION-EXCHANGE-RESIN; ACETIC-ACID; CATALYZED ESTERIFICATION; LACTIC-ACID; CHEMICAL-EQUILIBRIUM; COSOLVENT INFLUENCE; REACTION-KINETICS; SOLVENTS; NITROMETHANE; REDUCTION in [Weinbender, Thomas; Reiser, Oliver] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany; [Knierbein, Michael; Bittorf, Lukas; Held, Christoph; Sadowski, Gabriele] TU Dortmund Univ, Lab Thermodynam, Emil Figge Str 70, D-44227 Dortmund, Germany; [Siewert, Riko; Verevkin, Sergey P.] Univ Rostock, Dept Phys Chem, Dr Lorenz Weg 1, D-18059 Rostock, Germany in 2020.0, Cited 74.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

Thiourea-organocatalyzed Michael additions of diethyl malonate to various heteroaromatic nitroolefins (13 examples) have been studied under high-pressure (up to 800 MPa) and ambient pressure conditions. High pressure was conducive to enhanced product yields by a factor of 2-12 at a given reaction time, high reaction rates (reaction times were decreased from 72-24 h down to 4-24 h) and high enantioselectivity. Elucidating the effects of solvents for maximizing reaction rates and yields has been carried out using the Perturbed-Chain Polar Statistical Associating Fluid Theory (PCP-SAFT), allowing for the first time a prediction of the kinetic profiles under high-hydrostatic-pressure conditions.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Weinbender, T; Knierbein, M; Bittorf, L; Held, C; Siewert, R; Verevkin, SP; Sadowski, G; Reiser, O or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem