Category: 500-22-1

Recently I am researching about PHOSPHINE-PHOSPHITE LIGANDS; CHEMISTRY; OLEFINS; STEREOCHEMISTRY; INTERCONVERSION; DERIVATIVES; MECHANISM; NITRILES; ALKENES, Saw an article supported by the Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG). Formula: C6H5NO. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Frye, NL; Bhunia, A; Studer, A. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Hydrocyanation in the absence of toxic HCN gas is highly desirable. Addressing that challenge, transition-metal-catalyzed transfer hydrocyanation using safe HCN precursors has been developed, but these reagents generally require a Lewis acid for activation, and the control of regioselectivity often remains problematic. In this Letter, a Ni-catalyzed highly Markovnikov-selective transfer hydrocyanation that operates in the absence of any Lewis acid is reported. The readily prepared pro-aromatic 1-isopropylcyclohexa-2,5-diene-1-carbonitrile is used as the HCN source, and the reaction shows a broad substrate scope and high functional group tolerance. Terminal styrene derivatives, dienes, and internal alkynes are converted with good to excellent selectivities. Mechanistic studies provide insights into the origin of the regioselectivity.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Frye, NL; Bhunia, A; Studer, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Bilgicli, HG; Taslimi, P; Akyuz, B; Tuzun, B; Gulcin, I in [Bilgicli, Hayriye Genc; Akyuz, Busra] Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54050 Servidan, Sakarya, Turkey; [Taslimi, Parham] Bartin Univ, Dept Biotechnol, Fac Sci, Bartin, Turkey; [Tuzun, Burak] Cumhuriyet Univ, Dept Chem, Fac Sci, Sivas, Turkey; [Gulcin, Ilhami] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey published Synthesis, characterization, biological evaluation, and molecular docking studies of some piperonyl-based 4-thiazolidinone derivatives in 2020.0, Cited 51.0. Computed Properties of C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Heterocyclic compounds are of particular importance among pharmacologically active compounds. In this study, some piperonyl-based 4-thiazolidinone derivatives (2a-i) were synthesized and characterized by spectroscopic assays. All molecules were tested as enzyme inhibitory factors. These compounds were effective inhibitors of the enzymes acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), and the human carbonic anhydrase I and II isoforms (hCA I and II), with K-i values in the range of 8.90-66.51 nM for alpha-Gly, 94.8-289.5 nM for hCA I, 106.3-304.6 nM for hCA II, and 0.55-2.36 nM for AChE. The synthesized molecules were also studied theoretically. Molecular docking calculations were performed to investigate the interaction between the target protein and molecules. CA inhibitor compounds have been clinically used for almost 60 years as antiglaucoma and diuretic drugs. The inhibition of the AChE enzyme results in the blockage of ACh hydrolysis. On the contrary, the design of inhibitor compounds or/and modulators for AChE is of major interest as it is one of the most popular tools to prevent Alzheimer’s disease.

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bilgicli, HG; Taslimi, P; Akyuz, B; Tuzun, B; Gulcin, I or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Triphenylphosphine Oxide-Catalyzed Selective ,-Reduction of Conjugated Polyunsaturated Ketones WOS:000469034000018 published article about WITTIG REACTION; RECYCLE WASTE; REDUCTION; SEQUENCE; PHEROMONES; REAGENT; ESTERS in [Xia, Xuanshu; Lao, Zhiqi; Toy, Patrick H.] Univ Hong Kong, Dept Chem, Pokfulam Rd, Hong Kong, Peoples R China in 2019.0, Cited 25.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The scope of the triphenylphosphine oxide-catalyzed reduction of conjugated polyunsaturated ketones using trichlorosilane as the reducing reagent has been examined. In all cases studied, the ,-C=C double bond was selectively reduced to a C-C single bond while all other reducible functional groups remained unchanged. This reaction was applied to a large variety of conjugated dienones, a trienone, and a tetraenone. Additionally, a tandem one-pot Wittig/conjugate-reduction reaction sequence was developed to produce ,-unsaturated ketones directly from simple building blocks. In these reactions the byproduct of the Wittig reaction served as the catalyst for the reduction reaction. This strategy was then used in the synthesis of naturally occurring moth pheromones to demonstrate its utility in the context of natural-product synthesis.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Xia, XS; Lao, ZQ; Toy, PH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Galiana-Rosello, C; Aceves-Luquero, C; Gonzalez, J; Martinez-Camarena, A; Villalonga, R; de Mattos, SF; Soriano, C; Llinares, J; Garcia-Espana, E; Villalonga, P; Gonzalez-Rosende, ME in AMER CHEMICAL SOC published article about NATURAL-PRODUCTS; INTRACELLULAR ZINC; CORRELATION-ENERGY; IRON CHELATORS; CELL-GROWTH; DNA-DAMAGE; APOPTOSIS; COMPLEXES; DEPLETION; ANALOGS in [Galiana-Rosello, Cristina; Gonzalez, Jorge; Martinez-Camarena, Alvaro; Garcia-Espana, Enrique] Univ Valencia, Inst Ciencia Mol ICMol, Dept Quim Inorgan, Valencia 46980, Spain; [Galiana-Rosello, Cristina; Eugenia Gonzalez-Rosende, Maria] Univ CEU Cardenal Herrera, Fac Ciencias Salud, Dept Farm, C Ramon y Cajal S-N, Valencia 46115, Spain; [Galiana-Rosello, Cristina; Fernandez de Mattos, Silvia; Villalonga, Priam] Univ Illes Balears, Inst Univ Invest Ctencies Salut IUNICS, Canc Cell Biol Lab, Illes Balears 07122, Spain; [Galiana-Rosello, Cristina; Fernandez de Mattos, Silvia; Villalonga, Priam] Inst Invest Sanitaria Illes Balears IdISBa, Illes Balears 07122, Spain; [Villalonga, Ruth] Univ Illes Balears, Dept Quim, Illes Balears 07122, Spain; [Fernandez de Mattos, Silvia] Univ Illes Balears, Dept Biol Fonamental, Illes Balears 07122, Spain; [Soriano, Concepcion; Llinares, Jose] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain in 2020.0, Cited 79.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

In vitro viability assays against a representative panel of human cancer cell lines revealed that polyamines L1a and L5a displayed remarkable activity with IC50 values in the micromolar range. Preliminary research indicated that both compounds promoted G1 cell cycle arrest followed by cellular senescence and apoptosis. The induction of apoptotic cell death involved loss of mitochondrial outer membrane permeability and activation of caspases 3/7. Interestingly, L1a and L5a failed to activate cellular DNA damage response. The high intracellular zinc-chelating capacity of both compounds, deduced from the metal specific Zinquin assay and ZnL2+ stability constant values in solution, strongly supports their cytotoxicity. These data along with quantum mechanical studies have enabled to establish a precise structure-activity relationship. Moreover, L1a and L5a showed appropriate drug-likeness by in silico methods. Based on these promising results, L1a and L5a should be considered a new class of zinc-chelating anticancer agents that deserves further development.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Galiana-Rosello, C; Aceves-Luquero, C; Gonzalez, J; Martinez-Camarena, A; Villalonga, R; de Mattos, SF; Soriano, C; Llinares, J; Garcia-Espana, E; Villalonga, P; Gonzalez-Rosende, ME or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C6H5NO. Recently I am researching about SOLID PHARMACEUTICAL FORMULATIONS; RECEPTOR-BINDING-AFFINITY; MOLECULAR-DYNAMICS; DRUG DISCOVERY; ANTIMYCOBACTERIAL ACTIVITY; ANTITUBERCULAR ACTIVITY; ANTIPLATELET ACTIVITY; METHYL CELLULOSE; DESIGN; AMINOETHERS, Saw an article supported by the . Published in FUTURE SCI LTD in LONDON ,Authors: Papageorgiou, A; Foscolos, AS; Papanastasiou, IP; Vlachou, M; Siamidi, A; Vocat, A; Cole, ST; Kellici, TF; Mavromoustakos, T; Tsotinis, A. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Aim: There is a necessity for new drugs to be more efficient than today’s standard due to the emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) Results/methodology: 12 new isoniazid-based adamantane derivatives were synthesized and tested for their antitubercular activity. The pharmacological test results and the aqueous dissolution profile of representative examples of the new molecules are in agreement with the computational results obtained from docking poses and molecular dynamics simulations on the tested compounds. Conclusion: Among their congeners, the adamantane isonicotinoyl hydrazones Ia and Ih exhibit the best antitubercular activity (MIC = 0.04 mu g/ml) and the lowest cytotoxicity (selectivity index >= 2500). These results are useful for in future in vivo studies.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Papageorgiou, A; Foscolos, AS; Papanastasiou, IP; Vlachou, M; Siamidi, A; Vocat, A; Cole, ST; Kellici, TF; Mavromoustakos, T; Tsotinis, A or concate me.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. In 2020.0 EUR J MED CHEM published article about NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; RAW 264.7; CHALCONE DERIVATIVES; BIOLOGICAL EVALUATION; SUPEROXIDE-DISMUTASE; CELL; KAVA; SUPPRESSION; ARTHRITIS in [Yang, Youzhe; Teichmann, Alexander Tobias; Wieland, Frank Heinrich] Southwest Med Univ, Sichuan Prov Ctr Gynaecol & Breast Dis, Affiliated Hosp, Luzhou 646000, Peoples R China; [Yang, Youzhe; Wei, Zhe; Chen, Lijuan] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; [Yang, Youzhe; Wei, Zhe; Chen, Lijuan] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China; [Yang, Youzhe; Wei, Zhe; Chen, Lijuan] Collaborat Innovat Ctr, Chengdu 610041, Peoples R China; [Yang, Youzhe; Fan, Tiantian; Zhou, Li; Wang, Chao] Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Peoples R China; [Wang, Amu; Lei, Xiangui; Zhu, Yue; Yin, Jinxiang] Xihua Univ, Sch Sci, Chengdu 610039, Peoples R China in 2020.0, Cited 68.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Inflammation is a complex biological response to stimuli. Activated macrophages induced excessively release of pro-inflammatory cytokines and mediators such as endogenous radical nitric oxide (NO) play a significant role in the progression of multiple inflammatory diseases. Both natural and synthetic chalcones possess a wide range of bioactivities. In this work, thirty-nine chalcones and three related compounds, including several novel ones, based on bioactive kava chalcones were designed, synthesized and their inhibitory effects on NO production in RAW264.7 cells were evaluated. The novel compound (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3-methoxy-4-(3-morpholinopropoxy)phenyl)prop-2-en-1-one (53) exhibited a better inhibitory activity (84.0%) on NO production at 10 mu M (IC50 = 6.4 mu M) with the lowest cytotoxicity (IC50 > 80 mu M) among the tested compounds. Besides, western blot analysis indicated that compound 53 was a potent down-regulator of inducible nitric oxide synthase (iNOS) protein. Docking study revealed that compound 53 also can dock into the active site of iNOS. Furthermore, at the dose of 10 mg/kg/day, compound 53 could both significantly suppress the progression of inflammation on collagen-induced arthritis (CIA) and adjuvant-induced arthritis (AIA) models. In addition, the structure-activity relationship (SAR) of the kava chalcones based analogs was also depicted. (c) 2020 Elsevier Masson SAS. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yang, YZ; Wei, Z; Teichmann, AT; Wieland, FH; Wang, A; Lei, XG; Zhu, Y; Yin, JX; Fan, TT; Zhou, L; Wang, C; Chen, LJ or concate me.. Computed Properties of C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Ling, F; Chen, JC; Xie, Z; Hou, HC; Pan, ZT; Feng, C; Shen, HW; Zhong, WH in WILEY published article about FRUSTRATED LEWIS PAIRS; METAL-FREE HYDROGENATIONS; DERIVATIVES; ANTAGONISTS; REDUCTION; INSIGHTS; KETONES in [Ling, Fei; Chen, Jiachen; Xie, Zhen; Hou, Huacui; Pan, Zhentao; Feng, Cong; Shen, Haiwei; Zhong, Weihui] Zhejiang Univ Technol, Coll Pharmaceut Sci, Minist Educ, Key Lab Green Pharmaceut Technol & Related Equipm, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 44.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A metal-free method to construct quinoline derivatives via B(C6F5)(3)-catalyzed cyclization of anilines with aldehyde derivatives and pyruvates is described. This three-component cascade reaction provides an efficient approach for the easy access to various substituted quinoline-4-carboxylic esters with 71% to 92% yield. The utility of this methodology was further demonstrated by gram-scale formal synthesis of the antimalarial drug DDD107498.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ling, F; Chen, JC; Xie, Z; Hou, HC; Pan, ZT; Feng, C; Shen, HW; Zhong, WH or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 3-Pyridinecarboxaldehyde. I found the field of Chemistry very interesting. Saw the article CO2-switchable Pickering emulsions: efficient and tunable interfacial catalysis for alcohol oxidation in biphasic systems published in 2019.0, Reprint Addresses Wang, JL (corresponding author), Zhejiang Univ Technol, Coll Chem Engn, Biodiesel Lab China Petr & Chem Ind Federat, Zhejiang Prov Key Lab Biofuel,State Key Lab Breed, Hangzhou 310014, Zhejiang, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

CO2-responsive Pickering emulsions were fabricated on the basis of polymeric nanoaggregates with adjustable surface wettability. The static Pickering emulsion system provides an efficient and sustainable platform for in situ separation and reuse of catalysts in biphasic reactions.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Tang, J; Cao, SX; Wang, JL or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about CYCLOOXYGENASE; CELECOXIB; SAFETY; PYRIDAZIN-3(2H)-ONES; NSAIDS; DRUGS; RISK, Saw an article supported by the . Application In Synthesis of 3-Pyridinecarboxaldehyde. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Ahmed, EM; Hassan, MSA; El-Malah, AA; Kassab, AE. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

New pyridazinone and pyridazinthione derivatives were designed, synthesized and identified through performing H-1 NMR, C-13 NMR, IR and MS spectroscopic techniques. All the newly synthesized derivatives were evaluated for cyclooxygenase inhibitory activity and COX-2 selectivity using celecoxib and indomethacin, as reference drugs. All compounds showed highly potent COX-2 inhibitory activity with IC50 values in nano-molar range. Moreover, they demonstrated higher selectivity towards COX-2 inhibition compared to indomethacin. Compounds 3d, 3g and 6a exhibited significantly increased potency towards COX-2 enzyme compared to celecoxib with IC50 values of 67.23, 43.84 and 53.01 nM, respectively. They were 1.1-1.7 folds more potent than celecoxib (IC50 = 73.53 nM) and extremely much more potent than indomethacin (IC50 = 739.2 nM). Of particular interest, Compound 3g showed SI of 11.51 which was as high as that of celecoxib (SI 11.78). This compound was further challenged by in vivo anti-inflammatory activity assay and gastric ulcerogenic effect. It showed comparable anti-inflammatory activity to indomethacin as positive control. Moreover, the anti-inflammatory activity of compound 3g was found to be equipotent to celecoxib. Furthermore, the selective COX-2 inhibitor 3g exhibited a superior gastrointestinal safety profile compared to the reference drugs celecoxib and indomethacin with less number of ulcers and milder ulcer score. The molecular docking study of this compound with COX-2 protein revealed more favorable binding mode compared to celecoxib, explaining its remarkable COX-2 inhibitory potency.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ahmed, EM; Hassan, MSA; El-Malah, AA; Kassab, AE or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article The magnetic graphene oxide/NHC catalyzed aerobic direct amidation and cross-dehydrogenative coupling of aldehydes WOS:000493080000015 published article about N-HETEROCYCLIC CARBENES; AMIDE BOND FORMATION; OXIDATIVE AMIDATION; BRESLOW INTERMEDIATE; EFFICIENT; AMINES; REDUCTION; CYCLOHEXADIENONES; DESYMMETRIZATION; HYDROACYLATION in [Sepahvand, Heshmatollah; Ghasemi, Elnaz; Shahverdizadeh, Gholam Hossein] Islamic Azad Univ, Dept Chem, Tabriz Branch, Tabriz, Iran; [Sharbati, Mohammad] Univ Tehran, Sch Met & Mat Engn, Coll Engn, Tehran, Iran; [Mohammadi, Melika Sadat; Pirlar, Maghsoud Arshadi] Shahid Beheshti Univ, Dept Phys, Tehran, Iran in 2019.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

In this paper, the synthesis of a novel imidazolium based N-heterocyclic carbene (NHC) containing imidazopyridine substitutes using a three-component reaction is described. This compound was immobilized on magnetic graphene oxide (GO) to make a heterogeneous catalyst for the direct aerobic amidation of benzaldehyde derivatives under solvent-free conditions, as well as the intra- and intermolecular cross dehydrogenative coupling of aldehydes. In addition, the catalytic activity of the NHC catalyst was homogeneously studied in the presence of Fe3O4 nanoparticles under the same conditions, and showed good activity with lower yields than the heterogeneous catalyst.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Sepahvand, H; Ghasemi, E; Sharbati, M; Mohammadi, MS; Pirlar, MA; Shahverdizadeh, GH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem