Category: 500-22-1

Iwanejko, J; Brol, A; Szyja, B; Daszkiewicz, M; Wojaczynska, E; Olszewski, TK in [Iwanejko, Jakub; Brol, Anna; Wojaczynska, Elzbieta; Olszewski, Tomasz K.] Wroclaw Univ Sci & Technol, Dept Organ Chem, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland; [Szyja, Bartlomiej] Wroclaw Univ Sci & Technol, Div Fuels Chem & Technol, Fac Chem, Gdanska St 7-9, PL-50344 Wroclaw, Poland; [Daszkiewicz, Marek] Polish Acad Sci, Inst Low Temp & Struct Res, Okolna St 2, PL-50422 Wroclaw, Poland published Hydrophosphonylation of chiral hexahydroquinoxalin-2(1H)-one derivatives as an effective route to new bicyclic compounds: Aminophosphonates, enamines and imines in 2019.0, Cited 47.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A series of new aminophosphonate and phosphonic acid derivatives of hexahydroquinoxalin-2(1H)-ones and tetrahydroquinoxalin-2(1H)-ones were synthesised via hydrophosphonylation of the corresponding bicyclic imines with various dialkyl or diaryl H-phosphonates, H-phosphinates or H-phosphine oxides as phosphorus nucleophiles. The utility of the obtained compounds was demonstrated by their application as a source of phosphonate carbanion in the Horner-Wadsworth-Emmons (HWE) reaction leading to new bicyclic amines with an exocyclic, and unexpectedly, also endocyclic double bond depending on the structure of the aldehyde used. (C) 2019 Elsevier Ltd. All rights reserved.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Iwanejko, J; Brol, A; Szyja, B; Daszkiewicz, M; Wojaczynska, E; Olszewski, TK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about MULTISTEP ELECTRON-TRANSFER; NITROGEN-HETEROCYCLES; HETEROGENEOUS CATALYST; EFFICIENT SYNTHESIS; ALCOHOL OXIDATION; CARBON NANOTUBE; DEHYDROGENATION; METAL; GREEN; NANOCLUSTERS, Saw an article supported by the University of Kurdistan; Iranian National Science Foundation (INSF)Iran National Science Foundation (INSF) [96016233]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Moradi, S; Shokri, Z; Ghorashi, N; Navaee, A; Rostami, A. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Product Details of 500-22-1

We have designed a versatile reusable cooperative catalyst oxidation system, consisting of palladium nanoparticles and laccase with unprecedented reactivity. This biohybrid catalyst was synthesized by the stepwise immobilization of laccase as an enzyme and Pd as a nanometallic component into the same cavity of siliceous mesocellular foams (MCF). MCF and nanobiohybrid catalyst were characterized by BET, SAXS, SEM, EDX elemental mapping, ICP-OES, TEM, TGA, FT-IR, and XPS techniques and the stepwise immobilization of laccase enzyme and Pd onto MCF was evaluated through several compelling electrochemical studies. The present catalytic system exhibits high activity toward (i) aerobic oxidation of alcohols to the corresponding carbonyl compounds, (ii) aerobic oxidation of cyclohexanol and cyclohexanone to phenol and (iii) aerobic dehydrogenation of important N-heteocyclic compounds (tetrahydro quinazolines, quinazolonones, pyrazolines and 1,4-diydropyridines) in the presence of catalytic amount of hydroquinone (HQ) as mediator in phosphate buffer (0.1 M, pH 4.5, 4 mL)/THF (4%, 1 mL) as solvent under mild conditions. The immobilization of both oxygen-activating catalyst (laccase) and oxidizing catalyst (Pd) onto the same support makes the present catalyst system superior to other currently available heterogeneous palladium based catalytic aerobic oxidation systems. (C) 2020 Elsevier Inc. All rights reserved.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Moradi, S; Shokri, Z; Ghorashi, N; Navaee, A; Rostami, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Direct N- sec -Alkylation of Amides by Reaction of -Halohydroxamates and Sulfonylindoles: An Approach to 3-Indolyl Methanamines published in 2019.0. Category: pyridine-derivatives, Reprint Addresses Kang, TR (corresponding author), Chengdu Univ, Coll Pharm & Biol Engn, Chengdu 610106, Sichuan, Peoples R China.; Kang, TR (corresponding author), China West Normal Univ, Coll Chem & Chem Engn, Nanchong City 637002, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A catalyst-free, base-mediated N- sec -alkylation of amides by reaction of sulfonylindoles and -halohydroxamates has been developed. The N- sec -alkylation of amides reaction is based on an intermolecular nucleophilic addition of vinylogous imine with N -(benzyloxy)meth-acrylamide/azaoxyallyl cations formed in situ and represents a simple way to give polyfunctionalized 3-indolyl methanamines in good to excellent yields.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Chen, Y; Guo, XQ; Zhou, C; Chen, LM; Kang, TR or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies WOS:000462472500011 published article about ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO EVALUATION; DERIVATIVES; BENZOTHIADIAZOLE; COMPLEXES; POLYMERS; DESIGN in [Almandil, Noor Barak; Taha, Muhammad; Ibrahim, Mohamed; Mosaddik, Ashik] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Imran, Syahrul] Univ Teknol MARA UiTM, Atta ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor De, Malaysia; [Alqahtani, Mohammed A.; Bamarouf, Yasser A.; Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, CCSIT, POB 1982, Dammam 31441, Saudi Arabia in 2019.0, Cited 54.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

New series of quinoline-based thiadiazole analogs (1-20) were synthesized, characterized by EI-MS, H-1 NMR and C-13 NMR. All synthesized compounds were subjected to their antileishmanial potential. Sixteen analogs 1-10, 12, 13, 16, 17, 18 and 19 with IC50 values in the range of 0.04 +/- 0.01 to 5.60 +/- 0.21 mu M showed tremendously potent inhibition as compared to the standard pentamidine with IC50 value 7.02 +/- 0.09 mu M. Analogs 11, 14, 15 and 20 with IC50 8.20 +/- 0.35, 9.20 +/- 0.40, 7.20 +/- 0.20 and 9.60 +/- 0.40 mu M respectively showed good inhibition when compared with the standard. Structure-activity relationships have been also established for all compounds. Molecular docking studies were performed to determine the binding interaction of the compounds with the active site target.

COA of Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Almandil, NB; Taha, M; Rahim, F; Wadood, A; Imran, S; Alqahtani, MA; Bamarouf, YA; Ibrahim, M; Mosaddik, A; Gollapalli, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Construction of Chiral beta-Trifluoromethyl Alcohols Enabled by Catalytic Enantioselective Aldol-Type Reaction of CF3CHN2 published in 2019.0. COA of Formula: C6H5NO, Reprint Addresses Zhang, FG; Ma, JA (corresponding author), Tianjin Univ, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China.; Zhang, FG; Ma, JA (corresponding author), Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China.; Ma, JA (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A zinc-/quinine-mediated enantioselective Aldol-type reaction of trifluorodiazoethane (CF3CHN2) with various aldehydes is described. This study demonstrated the feasibility of utilizing CF3CHN2 as an effective hard nucleophile in catalytic asymmetric transformations. Furthermore, the synthetic utility of this protocol is exemplified by the construction of a diverse set of chiral beta-trifluoromethylated alcohols, including a valuable HDAC inhibitor precursor.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Rong, MY; Yang, LJ; Nie, J; Zhang, FG; Ma, JA or concate me.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Polyethylene glycol (PEG-400): An efficient one-pot green synthesis and anti-viral activity of novel alpha-diaminophosphonates WOS:000466645100001 published article about AMINO-PHOSPHONATES; 3-COMPONENT SYNTHESIS; ACID-DERIVATIVES; CATALYST; SOLVENT; AMINOPHOSPHONATES; INHIBITION; CHLORIDE; FACILE; KETONES in [Patnala, Harika] Andhra Loyola Inst Engn & Technol, Dept Chem, Vijayawada, Andhra Pradesh, India; [Abbo, Hanna S.; Titinchi, Salam J. J.] Univ Basrah, Dept Chem, Basrah, Iraq; [Abbo, Hanna S.; Titinchi, Salam J. J.] Univ Western Cape, Dept Chem, Cape Town, South Africa; [Potla, Krishna Murthy] Acharya Nagarjuna Univ, Post Grad Res Ctr, Bapatla Engn Coll, Dept Chem, Bapatla, Andhra Pradesh, India; [Chinnam, Sampath] BMS Coll Engn, Dept Chem, Bengaluru, Karnataka, India in 2019.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

An efficient and eco-friendly protocol has been accomplished for a series of novel alpha-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4 ‘-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 degrees C. All products were obtained in good to excellent yields (80-95%). The identity of the new synthesized compounds was confirmed by IR, H-1, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds 4b, 4c, 4j and 4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin. [GRAPHICS] .

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Patnala, H; Abbo, HS; Potla, KM; Titinchi, SJJ; Chinnam, S or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. In 2020.0 INORG CHIM ACTA published article about IMIDAZOLATE-BRIDGED DICOPPER(II); CHEMOSELECTIVE AEROBIC OXIDATION; SELECTIVE OXIDATION; CRYSTAL-STRUCTURE; HETEROBIMETALLIC COMPLEX; P-HYDROXYBENZALDEHYDE; DINUCLEAR COMPLEXES; MACROCYCLIC LIGAND; BENZYLIC ALCOHOLS; AQUEOUS-MEDIUM in [Asthana, Mrityunjaya] TCG Lifesci Private Ltd, Kolkata 700091, W Bengal, India; [Syiemlieh, Ibanphylla; Lal, Ram A.] North Eastern Hill Univ, Ctr Adv Study, Dept Chem, Shillong 793022, Meghalaya, India; [Kumar, Arvind] Univ West Indies, Fac Sci & Technol, Dept Chem, St Augustine, Trinidad Tobago in 2020.0, Cited 106.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

We report herein a ligand and additive- free [CuNi(bz)(3)(bpy)(2)]ClO4 catalyst system that efficiently and selectively catalyses the oxidation of a range of primary and secondary benzylic alcohols, 1 – heteroaryl alcohols, cinnamyl alcohol, and aliphatic alcohols mediated by hydrogen peroxide to the corresponding aldehydes and ketones, respectively.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Asthana, M; Syiemlieh, I; Kumar, A; Lal, RA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Novel access to 2-substituted quinolin-4-ones by nickel boride-mediated reductive ring transformation of 5-(2-nitrophenyl)isoxazoles WOS:000502890400010 published article about C-H AMIDATION; 4-QUINOLONES; ALKALOIDS; QUINOLONES; ALKYL; ARYL in [Lohrer, Bernhard; Bracher, Franz] Ludwig Maximilians Univ Munchen, Dept Pharm, Ctr Drug Res, Butenandtstr 5-13, D-81377 Munich, Germany in 2019.0, Cited 45.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reductive ring transformation of 3-substituted 5-(2-nitrophenyl)isoxazoles, readily accessible via 1,3-dipolar cycloaddition of 2-ethinylnitrobenzene with nitrile oxides, opens a novel access to 2-substituted quinolin-4-ones. Nickel boride, generated in situ from nickel chloride and sodium borohydride, allows, via simultaneous reduction of the nitro group and reductive cleavage of the isoxazole ring, the one-step conversion into the target quinolin-4-ones. This protocol tolerates various functional groups, except olefins, and thus is complementary to the reductive ring transformation with iron/acetic acid, which predominantly tolerates olefins. (C) 2019 Elsevier Ltd. All rights reserved.

Application In Synthesis of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Lohrer, B; Bracher, F or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay published in 2020.0. Recommanded Product: 500-22-1, Reprint Addresses Konig, B (corresponding author), Univ Regensburg, Fac Chem & Pharm, Inst Organ Chem, D-93040 Regensburg, Germany.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The combination of photoredox catalysis with the Wolff-Kishner (WK) reaction allows the difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff-Kishner reaction). Photoredox initiated radical addition to N-sulfonylhydrazones yields alpha-functionalized carbanions following the WK-type mechanism. With sulfur-centered radicals, the carbanions are further functionalized by reaction with electrophiles including CO2 and aldehydes, whereas CF3 radical addition furnishes a wide range of gem-difluoroalkenes through beta-fluoride elimination of the generated alpha-CF3 carbanions. More than 80 substrate examples demonstrate the broad applicability of this reaction sequence. A series of investigations including radical inhibition, deuterium labeling, fluorescence quenching, cyclic voltammetry, and control experiments support the proposed radical-carbanion relay mechanism.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, S; Cheng, BY; Srsen, M; Konig, B or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators WOS:000573916100021 published article about CELL-DEATH; ENDOPLASMIC-RETICULUM; DUAL ROLES; APOPTOSIS; EXPRESSION; STRESS; UBIQUITINATION; METABOLISM; ACTIVATION; INDUCTION in [Li, Baicun; Yao, Jie; Guo, Kaiqiang; He, Fengming; Chen, Kun; Lin, Zongxin; Liu, Shunzhi; Huang, Jiangang; Wu, Qiaoqiong; Fang, Meijuan; Zeng, Jinzhang; Wu, Zhen] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China; [Li, Baicun; Yao, Jie; Guo, Kaiqiang; He, Fengming; Chen, Kun; Lin, Zongxin; Liu, Shunzhi; Huang, Jiangang; Wu, Qiaoqiong; Fang, Meijuan; Zeng, Jinzhang; Wu, Zhen] Xiamen Univ, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China; [Li, Baicun] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China; [Li, Baicun] Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China in 2020.0, Cited 74.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Computed Properties of C6H5NO

Nur77 is a potential target for the treatment of cancer such as HCC. Herein, we detailed the discovery of a novel series of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as potential Nur77 modulators. The studies of antiproliferative activity and Nur77-binding affinity of target compounds resulted in the discovery of a lead candidate (10g), which was a good Nur77 binder (K-D = 3.58 +/- 0.16 mu M) with a broad-spectrum antiproliferative activity against all tested hepatoma cells (IC50 < 2.0 mu M) and was low toxic to normal LO2 cells. 10g could up-regulate Nur77 expression and mediate sub-cellular localization of Nur77 to induce apoptosis in hepatocellular carcinoma cell lines, which relied on 10g inducing Nur77-dependent autophagy and endoplasmic reticulum stress as the upstream of apoptosis. Moreover, the in vivo assays verified that 10g significantly inhibited xenograft tumor growth. These results indicate that 10g has the potential to be developed as a novel Nur77-targeting anti-hepatoma drug. (C) 2020 Elsevier Masson SAS. All rights reserved. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, BC; Yao, J; Guo, KQ; He, FM; Chen, K; Lin, ZX; Liu, SZ; Huang, JG; Wu, QQ; Fang, MJ; Zeng, JZ; Wu, Z or concate me.. Computed Properties of C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem