Category: 500-22-1

An article Reductive amination using cobalt-based nanoparticles for synthesis of amines WOS:000520399300001 published article about GENERAL-SYNTHESIS; HYDROGENATION; CATALYSTS; KETONES; AMMONIA; NANOCATALYSTS; GREEN in [Jagadeesh, Rajenahally, V; Beller, Matthias] Leibniz Inst Katalyse eV, Rostock, Germany; Univ Rostock, Rostock, Germany in 2020.0, Cited 42.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Reductive amination is essential to the preparation of amines (e.g., pharmaceuticals and industrial products). This protocol shows how to prepare and use graphitic shell-encapsulated cobalt-based nanoparticles as catalysts for this reaction. Reductive aminations are an essential class of reactions widely applied for the preparation of different kinds of amines, as well as a number of pharmaceuticals and industrially relevant compounds. In such reactions, carbonyl compounds (aldehydes, ketones) react with ammonia or amines in the presence of a reducing agent and form corresponding amines. Common catalysts used for reductive aminations, especially for the synthesis of primary amines, are based on precious metals or Raney nickel. However, their drawbacks and limited applicability inspired us to look for alternative catalysts. The development of base-metal nanostructured catalysts is highly preferable and is crucial to the advancement of sustainable and cost-effective reductive amination processes. In this protocol, we describe the preparation of carbon-supported cobalt-based nanoparticles as efficient and practical catalysts for synthesis of different kinds of amines by reductive aminations. Template synthesis of a cobalt-triethylenediamine-terephthalic acid metal-organic framework on carbon and subsequent pyrolysis to remove the organic template resulted in the formation of supported single cobalt atoms and nanoparticles. Applying these catalysts, we have synthesized structurally diverse benzylic, aliphatic and heterocyclic primary, secondary and tertiary amines, including pharmaceutically relevant products, starting from inexpensive and easily accessible carbonyl compounds with ammonia, nitro compounds or amines and molecular hydrogen. To prepare this cobalt-based catalyst takes 26 h, and the reported catalytic reductive amination reactions can be carried out within 18-28 h.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Murugesan, K; Chandrashekhar, VG; Senthamarai, T; Jagadeesh, RV; Beller, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Copper(I)- and Mesoionic-Hydroxyamide-Catalyzed Chemoselective Aerobic Oxidation of Primary Benzylic Alcohols WOS:000458925800012 published article about ALDEHYDES; MECHANISM in [Matsukawa, Yuta; Hirashita, Tsunehisa] Nagoya Inst Technol, Grad Sch Engn, Life Sci & Appl Chem, Showa Ku, Gokiso Cho, Nagoya, Aichi 4668555, Japan in 2019.0, Cited 15.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

A new aerobic oxidation system consisting of Cu(I)I, 2,2′-bipyridine, N-methyl imidazole, and a mesoionic hydroxyamide was developed, with which selective oxidation of a broad range of benzylic alcohols was achieved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Matsukawa, Y; Hirashita, T or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. Bas, S; Yamashita, Y; Kobayashi, S in [Bas, Sebastian; Yamashita, Yasuhiro; Kobayashi, Shu] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan published Development of Bronsted Base-Photocatalyst Hybrid Systems for Highly Efficient C-C Bond Formation Reactions of Malonates with Styrenes in 2020, Cited 31. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Bronsted base-photocatalyst hybrid systems have been developed for reactions of malonates with styrene derivatives. The concept of this process lies in the photo-oxidation of catalytic amounts of the enolate to form reactive radicals that react with alkene double bonds under mild reaction conditions. This is an example of visible-light-activated C-C bond formation reactions of malonates with alkenes to realize high atom economy under very mild reaction conditions without using any transition-metal catalysts.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bas, S; Yamashita, Y; Kobayashi, S or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019 ORG LETT published article about COPPER-CATALYZED REACTION; ENANTIOSELECTIVE SYNTHESIS; AMINO-ACIDS; ALCOHOLS; FLUORIDE; NITRONES; DERIVATIVES; PYRAZOLES; REAGENT; RING in [Hosseini, Abolfazl; Schreiner, Peter R.] Justus Liebig Univ, Inst Organ Chem, Heinrich Buff Ring 17, D-35392 Giessen, Germany in 2019, Cited 55. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1

A new Kinugasa reaction protocol has been elaborated for the one-pot synthesis of 4-substituted beta-lactams utilizing calcium carbide and nitrone derivatives. Calcium carbide is thereby activated by TBAF center dot 3H(2)O in the presence of CuCl/NMI. The ease of synthesis and use of inexpensive chemicals provides rapid access of practical quantities of beta-lactams exclusively substituted at position 4.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Hosseini, A; Schreiner, PR or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. de Salles, HD; da Silva, TL; Radatz, CS; Affeldt, RF; Benvenutti, EV; Schneider, PH in [de Salles, Helena D.; Benvenutti, Edilson, V; Schneider, Paulo H.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil; [da Silva, Tiago L.] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149,Bloco A, BR-21941909 Rio de Janeiro, RJ, Brazil; [Radatz, Catia S.] Univ Fed Pelotas UFPeI, CCQFA, BR-96010900 Pelotas, RS, Brazil; [Affeldt, Ricardo F.] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil published Imidazo[1,2-a]pyridine A(3)-Coupling Catalyzed by a Cu/SiO2 Material in 2019.0, Cited 60.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A(3)-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%). which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of reaction intermediates inside the pores of the mesoporous material prior to 5-exo-dig cyclization.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact de Salles, HD; da Silva, TL; Radatz, CS; Affeldt, RF; Benvenutti, EV; Schneider, PH or concate me.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. Recently I am researching about IONIC LIQUIDS; HIGHLY EFFICIENT; HIGH-PERFORMANCE; BUILDING-BLOCK; CAPTURE; DESIGN; OXIDE, Saw an article supported by the NSAF [U1530262]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21875021, 21576026]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Hu, BP; Shi, QR; Lu, FP; Zhang, PC; Peng, PP; Zhao, CF; Du, Y; Su, H; Li, SH; Pang, SP; Nie, FD. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

We report a greener and more-general organic method for the synthesis of functional organic salts containing organic anions through a Schiff base reaction between readily available aldehydes and simple aminoguanidinium salts. This reaction is operationally simple, free of metal salts, and forms water as the sole byproduct. The broad scope and good functional-group compatibility of this method permit its use to provide ready access to a library of more than 70 distinct organic salts, including those of heterocyclic anions, complex pharmaceutical anions, and polyanions, which are difficult to obtain through classical inorganic methods. Moreover, choosing different aldehydes and organic anions provides a convenient method for modulating or improving the functional properties of the designed organic salts, such as their melting points, fluorescence, and energetic properties. We therefore expect that this method will open new opportunities for the discovery and functionalization of a wide variety of organic salts and functional materials.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Hu, BP; Shi, QR; Lu, FP; Zhang, PC; Peng, PP; Zhao, CF; Du, Y; Su, H; Li, SH; Pang, SP; Nie, FD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. In 2019.0 BIOORG CHEM published article about QUINOLINE BASED CHALCONES; MOLECULAR DOCKING; ADME EVALUATION; DRUG DISCOVERY; DESIGN; AGENTS; CYTOTOXICITY; PREDICTION; HYBRIDS; ELECTRONEGATIVITY in [Polo, Efrain; Ibarra-Arellano, Nicol; Prent-Penaloza, Luis; Gutierrez, Margarita] Univ Talca, Lab Sintesis Organ, Inst Quim Recursos Nat, Casilla 747, Talca 3460000, Chile; [Morales-Bayuelo, Alejandro] Univ Sinu, Ciencias Salud, Grp Invest Basicas & Clin Univ Sinu GIBACUS, Secc Cartagena, Cartagena, Colombia; [Henao, Jose] Univ Ind Santander, Grp Invest Quim Estruct GIQUE, Escuela Quim, Fac Ciencias, AA 678,Carrera 27,Calle 9 Ciudadela Univ, Bucaramanga, Colombia; [Galdamez, Antonio] Univ Chile, Dept Quim, Fac Ciencias, Santiago 7800003, Chile in 2019.0, Cited 90.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The chalcone and bis-chalcone derivatives have been synthesized under sonication conditions via Claisen-Schmidt condensation with KOH in ethanol at room temperature (20-89%). The structures were established on the basis of NMR, IR, Single-crystal XRD, and MS. The best compound 3u had inhibitory activity (IC50 = 7.50 mu M). The synthesis, the antioxidative properties, chemical reactivity descriptors supported in Density Functional Theory (DFT), acetylcholinesterase (AChE) inhibition and their potential binding modes, and affinity were predicted by molecular docking of a number of morpholine-chalcones and quinoline-chalcone. A series of bis-chalcones are also reported. Molecular docking and an enzyme kinetic study on compound 3u suggested that it simultaneously binds to the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. Moreover, the pharmacokinetic profile of these compounds was investigated using a computational method.

Category: pyridine-derivatives. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Polo, E; Ibarra-Arellano, N; Prent-Penaloza, L; Morales-Bayuelo, A; Henao, J; Galdamez, A; Gutierrez, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of 3-Pyridinecarboxaldehyde. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis, characterization, biological evaluation, and molecular docking studies of some piperonyl-based 4-thiazolidinone derivatives published in 2020.0, Reprint Addresses Bilgicli, HG (corresponding author), Sakarya Univ, Fac Arts & Sci, Dept Chem, TR-54050 Servidan, Sakarya, Turkey.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Heterocyclic compounds are of particular importance among pharmacologically active compounds. In this study, some piperonyl-based 4-thiazolidinone derivatives (2a-i) were synthesized and characterized by spectroscopic assays. All molecules were tested as enzyme inhibitory factors. These compounds were effective inhibitors of the enzymes acetylcholinesterase (AChE), alpha-glycosidase (alpha-Gly), and the human carbonic anhydrase I and II isoforms (hCA I and II), with K-i values in the range of 8.90-66.51 nM for alpha-Gly, 94.8-289.5 nM for hCA I, 106.3-304.6 nM for hCA II, and 0.55-2.36 nM for AChE. The synthesized molecules were also studied theoretically. Molecular docking calculations were performed to investigate the interaction between the target protein and molecules. CA inhibitor compounds have been clinically used for almost 60 years as antiglaucoma and diuretic drugs. The inhibition of the AChE enzyme results in the blockage of ACh hydrolysis. On the contrary, the design of inhibitor compounds or/and modulators for AChE is of major interest as it is one of the most popular tools to prevent Alzheimer’s disease.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Bilgicli, HG; Taslimi, P; Akyuz, B; Tuzun, B; Gulcin, I or concate me.. Quality Control of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 J MED CHEM published article about ACETYLCHOLINE-RECEPTORS; IN-VITRO; QUINOLINE DERIVATIVES; THERAPEUTIC TARGETS; LIGAND EFFICIENCY; FULL AGONIST; ALPHA-4-BETA-2; VARENICLINE; EPIBATIDINE; SUBTYPES in [Manetti, Dina; Bartolucci, Gianluca; Bellucci, Cristina; Chiaramonte, Niccolo; Dei, Silvia; Teodori, Elisabetta; Romanelli, Maria Novella] Univ Florence, Sect Pharmaceut & Nutraceut Sci, Dept Neurosci Psychol Drug Res & Childs Hlth NEUR, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Garifulina, Alexandra; Spirova, Ekaterina; Shelukhina, Irina; Tsetlin, Victor] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Dept Mol Basis Neurosignaling, Miklukho Maklaya St 16-10, Moscow 117997, Russia; [Bazzicalupi, Carla] Univ Florence, Dept Chem Ugo Schiff, Via Lastruccia 3, I-50019 Sesto Fiorentino, Italy; [Mannelli, Lorenzo Di Cesare; Ghelardini, Carla] Univ Florence, Sect Pharmacol & Toxicol, Dept NEUROFARBA, Viale G Pieraccini 6, I-50139 Florence, Italy; [Gratteri, Paola] Univ Firenze, Lab Mol Modeling Cheminformat, Dept NEUROFARBA, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Gratteri, Paola] Univ Firenze, QSAR, Via Ugo Schiff 6, I-50019 Sesto Fiorentino, Italy; [Varani, Katia] Univ Ferrara, Inst Pharmacol, Via Fossato di Mortara 17-19, I-44100 Ferrara, Italy in 2019.0, Cited 64.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Formula: C6H5NO

A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat cortex against [H-3]-cytisine and [3H]-methyllycaconitine to measure their affinity for alpha 4 beta 2* and alpha 7* nicotinic receptors. The new derivatives showed some preference for the alpha 4 beta 2* over the alpha 7* subtype, with their affinity being dependent on the endo/exo isomerism and on the methylation degree of the basic nitrogen. The endo primary amines displayed the lowest K-i values on both receptor subtypes. Selected compounds (1a, 2a, 3a, and 6a) were tested on heterologously expressed alpha 4 beta 2, alpha 7, and alpha 3 beta 2 receptors and on SHSY-5Y cells. Compounds 1a and 2a showed alpha 4 beta 2 antagonistic properties while behaved as full agonists on recombinant alpha 7 and on SHSYSY cells. On the alpha 3 beta 2 subtype, only the chloro derivative 2a showed full agonist activity and submicromolar potency (EC50 = 0.43 mu M). The primary amines described here represent new chemotypes for the alpha 7 and alpha 3* receptor subtypes.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Manetti, D; Garifulina, A; Bartolucci, G; Bazzicalupi, C; Bellucci, C; Chiaramonte, N; Dei, S; Mannelli, LD; Ghelardini, C; Gratteri, P; Spirova, E; Shelukhina, I; Teodori, E; Varani, K; Tsetlin, V; Romanelli, MN or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C6H5NO. Zha, GF; Fang, WY; Leng, J; Qin, HL in [Zha, Gao-Feng; Fang, Wan-Yin; Leng, Jing; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China published A Simple, Mild and General Oxidation of Alcohols to Aldehydes or Ketones by SO2F2/K2CO3 Using DMSO as Solvent and Oxidant in 2019.0, Cited 67.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A practical, general and mild oxidation of primary and secondary alcohols to carbonyl compounds proceeds in yields of up to 99% using SO2F2 as electrophile in DMSO as both the oxidant and the solvent at ambient temperature. No moisture- and oxygen-free conditions are required. Stoichiometric amount of inexpensive K2CO3, which generates easy to separate by-products, is used as the base. Thus, 5-gram scale runs proceeded in nearly quantitative yields by a simple filtration as the work-up. The use of a polar solvent such as DMSO, which usually promotes competing Pummerer rearrangement, is also noteworthy. This protocol is compatible with a variety of common N-, O-, and S-functional groups on (hetero)arene, alkene and alkyne substrates (68 examples). The protocol was applied (99% yield) to a formal synthesis of the important cholesterol-lowering drug Rosuvastatin.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zha, GF; Fang, WY; Leng, J; Qin, HL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem