Category: 500-22-1

An article Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity WOS:000467781700024 published article about H-3 RECEPTOR; NEURONAL HISTAMINE; H3 RECEPTOR; AGONIST; PROTEIN; SYSTEM; DISCOVERY; TARGET; 2-AMINOPYRIMIDINES; IDENTIFICATION in [Kumar, Ajeet; Yadav, Anubhav; Dogra, Shalini; Sona, Chandan; Umrao, Deepmala; Yadav, Prem N.] Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, Uttar Pradesh, India; [Pasam, Venkata Reddy; Thakur, Ravi Kumar; Singh, Kartikey; Tripathi, Rama Pati] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India; [Singh, Maninder; Siddiq, Mohammad Imran] Cent Drug Res Inst, Mol & Struct Biol Div, Lucknow 226031, Uttar Pradesh, India; [Shukla, Mahendra; Jaiswal, Swati; Ahmad, Hafsa; Rashid, Mamunur; Singh, Sandeep K.; Wahajuddin, Muhammad; Dwivedi, Anil Kumar; Lal, Jawahar] Cent Drug Res Inst, Pharmaceut & Pharmacokinet Div, Lucknow 226031, Uttar Pradesh, India; [Shukla, Mahendra; Jaiswal, Swati; Ahmad, Hafsa; Rashid, Mamunur; Singh, Sandeep K.; Wahajuddin, Muhammad; Dwivedi, Anil Kumar; Lal, Jawahar] Cent Drug Res Inst, CSIR, Lucknow 226031, Uttar Pradesh, India; [Siddiq, Mohammad Imran; Tripathi, Rama Pati; Yadav, Prem N.] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India; [Tripathi, Rama Pati] Natl Inst Pharmaceut Educ & Res Raebareli, New Transit Campus,Bijnor Rd, Lucknow 226002, Uttar Pradesh, India in 2019.0, Cited 85.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several neurotransmitters including histamine and various essential physiological processes, such as feeding, arousal, cognition, and pain. The H3R is considered as a drug target for the treatment of several central nervous system disorders. We have synthesized and identified a novel series of 4-aryl-6-methyl-5,6,7,8-tetrahydroquinazolinamines that act as selective H3R antagonists. Among all the synthesized compounds, in vitro and docking studies suggested that the 4-methoxy-phenyl-substituted tetrahydroquinazolinamine compound 4c has potent and selective H3R antagonist activity (IC50 < 0.04 mu M). Compound 4c did not exhibit any activity on the hERG ion channel and pan-assay interference compounds liability. Pharmacokinetic studies showed that 4c crosses the blood brain barrier, and in vivo studies demonstrated that 4c induces anorexia and weight loss in obese, but not in lean mice. These data reveal the therapeutic potential of 4c as an anti-obesity candidate drug via antagonizing the H3R. SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kumar, A; Pasam, VR; Thakur, RK; Singh, M; Singh, K; Shukla, M; Yadav, A; Dogra, S; Sona, C; Umrao, D; Jaiswal, S; Ahmad, H; Rashid, M; Singh, SK; Wahajuddin, M; Dwivedi, AK; Siddiq, MI; Lal, J; Tripathi, RP; Yadav, PN or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Gorodnicheva, NV; Vasil’eva, OS; Ostroglyadov, ES; Baichurin, RI; Makarenko, SV; Karamov, FA; Lodochnikova, OA; Litvinov, IA in [Gorodnicheva, N. V.; Vasil’eva, O. S.; Ostroglyadov, E. S.; Baichurin, R. I.; Makarenko, S. V.] Herzen State Pedag Univ Russia, 48 Nab R Moiki, St Petersburg 191186, Russia; [Karamov, F. A.] Kazan Natl Res Tech Univ, 10 Ul K Marksa, Kazan 420111, Russia; [Lodochnikova, O. A.; Litvinov, I. A.] Russian Acad Sci, Kazan Sci Ctr, Fed Res Ctr, AE Arbuzov Inst Organ & Phys Chem, 8 Ul Akad Arbuzova, Kazan 420088, Russia published 4-Het(aryl)-2-pyrrolidone-3(5)-carboxylic acid alkyl(hetaryl)idenecarbohydrazides: synthesis and structure in 2020.0, Cited 25.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

4-Het(aryl)-2-pyrrolidone-3(5)-carboxylic acid hydrazides react with aromatic aldehydes, acetone, and acetophenone to give new representatives of N ‘-alkyl(hetaryl)idenecarbohydrazides of (3R*,4S*)-4-het(aryl)-2-pyrrolidone-3- and (4R*,5R*)-4-het(aryl)-2-pyrrolidone-5-carboxylic acids.

Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Gorodnicheva, NV; Vasil’eva, OS; Ostroglyadov, ES; Baichurin, RI; Makarenko, SV; Karamov, FA; Lodochnikova, OA; Litvinov, IA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Computed Properties of C6H5NO. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators published in 2020.0, Reprint Addresses Thakur, GA (corresponding author), Northeastern Univ, Bouve Coll Hlth Sci, Sch Pharm, Dept Pharmaceut Sci, Boston, MA 02115 USA.; Laprairie, RB (corresponding author), Univ Saskatchewan, Coll Pharm & Nutr, 104 Clin Pl, Saskatoon, SK S7N 2Z4, Canada.; Laprairie, RB (corresponding author), Dalhousie Univ, Fac Med, Dept Pharmacol, 5850 Coll St, Halifax, NS B3H 4R2, Canada.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Cannabinoid 1 receptor (CB1R) allosteric ligands hold a far-reaching therapeutic promise. We report the application of fluoro- and nitrogen-walk approaches to enhance the drug-like properties of GAT211, a prototype CB1R allosteric agonist-positive allosteric modulator (ago-PAM). Several analogs exhibited improved functional potency (cAMP, beta-arrestin 2), metabolic stability, and aqueous solubility. Two key analogs, GAT591 (6r) and GAT593 (6s), exhibited augmented allosteric-agonist and PAM activities in neuronal cultures, improved metabolic stability, and enhanced orthosteric agonist binding (CP55,940). Both analogs also exhibited good analgesic potency in the CFA inflammatory-pain model with longer duration of action over GAT211 while being devoid of adverse cannabimimetic effects. Another analog, GAT592 (9j), exhibited moderate ago-PAM potency and improved aqueous solubility with therapeutic reduction of intraocular pressure in murine glaucoma models. The SAR findings and the enhanced allosteric activity in this class of allosteric modulators were accounted for in our recently developed computational model for CB1R allosteric activation and positive allosteric modulation. [GRAPHICS] .

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Garai, S; Kulkarni, PM; Schaffer, PC; Leo, LM; Brandt, AL; Zagzoog, A; Black, T; Lin, XY; Hurst, DP; Janero, DR; Abood, ME; Zimmowitch, A; Straiker, A; Pertwee, RG; Kelly, M; Szczesniak, AM; Denovan-Wright, EM; Mackie, K; Hohmann, AG; Reggio, PH; Laprairie, RB; Thakur, GA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A [bmim]Cl-promoted domino protocol using an isocyanide-based [4+1]-cycloaddition reaction for the synthesis of diversely functionalized 3-alkylamino-2-alkyl/aryl/hetero-aryl indolizine-1-carbonitriles under solvent-free conditions WOS:000518019300009 published article about IONIC LIQUID; MULTICOMPONENT SYNTHESIS; EFFICIENT CATALYST; C-C; INDOLIZINES; DERIVATIVES; ALKYNES; ACCESS; AMINES; CYCLIZATION in [Atar, Amol Balu; Kang, Jongmin] Sejong Univ, Dept Chem, Seoul 143747, South Korea; [Jadhav, Arvind H.] Jain Univ, CNMS, Jain Global Campus, Bangalore 562112, Karnataka, India in 2020.0, Cited 63.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A domino protocol involving aldehydes, isocyanides and 2-pyridylacetonitrile in the presence of [bmim]Cl as a promoter and solvent for the synthesis of 3-alkylamino-2-alkyl/arylindolizine-1-carbonitriles is described. A wide range of alkyl, aryl and hetero-aryl aldehydes reacted with 2-pyridylacetonitrile and isocyanides, leading to indolizine derivatives with high selectivity, high atom economy, and good to excellent yields. This straight-forward and highly efficient method allows the synthesis of bis-indolizine-1-carbonitrile derivatives.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Atar, AB; Kang, J; Jadhav, AH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Category: pyridine-derivatives. Recently I am researching about ONE-POT SYNTHESIS; FRIEDLANDER SYNTHESIS; NANOPARTICLES; COMPLEX; SURFACE; ACID; NANOCATALYST; DERIVATIVES; QUINOLINES; PHOSPHINE, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe-Cr-Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe-Cr-Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop. Graphic abstract

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about TRANSFER HYDROGENATION; CONJUGATE REDUCTION; CYCLIZATION; HYDRODEHALOGENATION; CONSTRUCTION; CHLORIDES; OLEFINS; ESTER; ACID, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21202112, 21738002, 21776148]; Ph.D. Programs Foundation of the Ministry of Education of ChinaMinistry of Education, China [20123201120019]; Suzhou Science and Technology Project [ZXY201435]; PAPD (Priority Academic Program Development of Jiangsu Higher Education Institutions); Natural Science Foundation of Shandong ProvinceNatural Science Foundation of Shandong Province [ZR2016BM07]; Key Research & Development Project of Shandong [2018GSF118224]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liu, Y; Mao, YJ; Hu, YW; Gui, JJ; Wang, L; Wang, W; Zhang, SL. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde. Recommanded Product: 3-Pyridinecarboxaldehyde

Sodium hydride was employed as a Michael donor under the catalysis of PdCl2 for 1,4-conjugate reductions of alpha, beta-unsaturated carbonyl compounds, which features operational simplicity, mild conditions and high atom-economy. The merits of NaH as a reductant were demonstrated by the one-pot or cascade reactions for the syntheses of complex molecules.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Liu, Y; Mao, YJ; Hu, YW; Gui, JJ; Wang, L; Wang, W; Zhang, SL or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Magnetic Fe-Cr-Ni oxide alloy nano-belts prepared from the chemical decomposition of a stainless steel screw (a top-down approach): an efficient and cheap catalyst for multicomponent reactions WOS:000519963900003 published article about ONE-POT SYNTHESIS; FRIEDLANDER SYNTHESIS; NANOPARTICLES; COMPLEX; SURFACE; ACID; NANOCATALYST; DERIVATIVES; QUINOLINES; PHOSPHINE in [Kazemnejadi, Milad; Zeinali, Atefeh; Nasseri, Mohammad Ali] Univ Birjand, Dept Chem, Fac Sci, Birjand 97175615, Iran; [Sharafi, Zeinab] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran; [Mahmoudi, Boshra] Sulaimani Polytech Univ, Res Ctr, Sulaimani 46001, Kurdistan Regio, Iraq in 2020.0, Cited 48.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. HPLC of Formula: C6H5NO

A new, cheap, and accessible method has been used for the preparation of nano-belts from the chemical decomposition (top-down approach) of a cheap stainless steel screw and found as an efficient magnetically recyclable nanocatalyst for the preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild reaction conditions. The nano-belts, Fe-Cr-Ni oxide alloy, was prepared in a two-step synthesis and characterized with various instrumental methods. Due to magnetic property of the screw (a ferritic-alloy), the resultant nano-belts is magnetic. Magnetic Fe-Cr-Ni alloy nano-belts were applied toward efficient preparation of quinolines and 1,8-dioxo-octahydroxanthenes under mild conditions. The catalyst could be readily recovered and recycled for several consecutive runs, while it suffers from a very low metal leaching and subsequently efficiency drop. Graphic abstract

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kazemnejadi, M; Sharafi, Z; Mahmoudi, B; Zeinali, A; Nasseri, MA or concate me.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents published in 2020.0. Quality Control of 3-Pyridinecarboxaldehyde, Reprint Addresses Taha, M (corresponding author), Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, PO Box1982, Dammam 31441, Saudi Arabia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Leishmaniasis has affected a wider part of population around the globe. Most often, the existing regiments to battle against leishmaniasis are inadequate and limited. In our ongoing efforts to develop new leishmanicidal agents, we have synthesized a series of novel and symmetrical bis-Schiff base-disulfide hybrids 1-27. Intermediate disulfide was synthesized from corresponding 2-aminothiol followed by reacting the coupled adduct with various aromatic aldehydes. All these compounds showed outstanding inhibition when compared with standard (Table 1). Out of twenty seven analogues, twenty two analogues i.e. 1-5, 7-13, 17-21, 23-27 analogues showed excellent inhibitory potential with EC50 values ranging from 0.010 +/- 0.00 to 0.096 +/- 0.01 mu M while five compounds i.e. 6, 14-16, and 22 showed good inhibitory potential with EC50 values ranging from 0.10 +/- 0.00 to 0.137 +/- 0.01 mu M when compared with the standard Amphotericin B. Structure-activity relationship has been established while molecular docking studies were performed to pin the binding interaction of active molecules. This study will help to develop new antileishmanial lead compounds.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Taha, M; Sain, AA; Ali, M; Anouar, E; Rahim, F; Ismail, NH; Adenan, MI; Imran, S; Al-Harrasi, A; Nawaz, F; Iqbal, N; Khan, KM or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 500-22-1. In 2020.0 CHEM ENG SCI published article about DYNAMIC KINETIC RESOLUTION; ESCHERICHIA-COLI; SUBSTRATE; MECHANISM in [Wang, Li-Chao; Xu, Lian; Su, Bing-Mei; Lin, Juan] Fuzhou Univ, Coll Chem Engn, Fuzhou 350116, Peoples R China; [Wang, Li-Chao; Xu, Lian; Xu, Xin-Qi; Su, Bing-Mei; Lin, Juan] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China in 2020.0, Cited 33.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

L-threonine aldolase (LTA) is a PLP-dependent enzyme that can reversibly catalyze aldol reaction of glycine and acetaldehyde to produce beta-hydroxy-alpha-amino acids. In the present work, a putative Ita gene from Actinocorallia herbida (AhLTA) was mined and over-expressed in Escherichia coli BL21 (DE3). The substrate spectrum assay indicated that AhLTA only used glycine as donor substrate and tolerated a wild range of aromatic aldehydes as acceptor substrates. It was found that the type and position of substituents in the aromatic aldehydes exerted a significant impact on the activity and stereoselectivity at beta-carbon of AhLTA. Among those substrates, AhLTA could catalyze glycine and 4-methylsulphonyl benzaldehyde (14a) to produce L-threo-4-methylsulfonylphenylserine ((2S,3R)-14b) with high conversion (94.4%) and moderate stereoselectivity (19% de). By conditional optimization, the de value of (2S, 3R)-14b was improved to 61% and the conversion was 75%. Taken together, our study suggested that AhLTA might be a promising catalyst for producing chiral beta-hydroxy-alpha-amino acids. (C) 2020 Elsevier Ltd. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, LC; Xu, L; Xu, XQ; Su, BM; Lin, J or concate me.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. In 2020.0 J PHYS CHEM C published article about AGGREGATION-INDUCED EMISSION; FLUORESCENCE; DERIVATIVES; MECHANOCHROMISM; LUMINESCENCE; ISOMERS; COLOR in [Li, Ye-Xin; Chen, You-Gui; Yu, Zhen-Feng; Yang, Xiao-Feng; Nie, Yong; Cui, Yu; Sun, Guo-Xin] Jinan Univ, Sch Chem & Chem Engn, Jinan 250022, Peoples R China in 2020.0, Cited 31.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The mechanism of most mechanofluorochromic (MFC) materials is related to a noncovalent change in aggregate packing. It is still a challenge to clarify the respective effects of molecular conformation and intermolecular interaction on the MFC performance. Herein, a new (9-anthryl)vinyl derivative APYB with a polymorph-dependent multicolor-switchable MFC property is reported. APYB has only one torsion unit in the molecule configuration and could form four different crystal phases (APYB-a, APYB-b, APYB-c, and APYB-d). Furthermore, all polymorphs are MFC-active. Therefore, it provides a rare and direct case to correlate the aggregate packing with MFC performance. The solid-state emission could be finely tuned from 465 to 500 nm by virtue of polymorphism. Crystal structure analyses and optical studies reveal that an increasing twist angle could result in a blue shift in the fluorescence spectrum and a high-contrast MFC performance. In contrast, strong intermolecular interactions could lead to high emission efficiency and amorphization difficulty during the mechanical grinding. A tricolor-switchable MFC phenomenon was observed for APYB-a, while both APYB-b and APYB-d display a reversible bicolor-changing MFC behavior. As for APYB-c, mechanical grinding only causes a minor change in the emission spectrum. However, two competitive reverse transformation routes were found when treating the ground sample with organic solvent vapor. XRD analyses show that the MFC mechanism for APYB-a, APYB-c, and APYB-d is a crystal-to-amorphous transformation, while only partial amorphization was observed in the MFC behavior of APYB-b. The acidochromism effects of APYB-a and APYB-b were also investigated. They also display multicolor changes due to the polymorphic nature of APYB. Interestingly, in the deprotonation process, NH3 vapor could induce a different transformation route and color change from NEt3.

Safety of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, YX; Chen, YG; Yu, ZF; Yang, XF; Nie, Y; Cui, Y; Sun, GX or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem