Category: 500-22-1

Authors Van Zandt, MC; Jagdmann, GE; Whitehouse, DL; Ji, M; Savoy, J; Potapova, O; Cousido-Siah, A; Mitschler, A; Howard, EI; Pyle, AM; Podjarny, AD in AMER CHEMICAL SOC published article about BINUCLEAR MANGANESE CLUSTER; CRYSTAL-STRUCTURE; ARGININE; PURIFICATION; METABOLISM; EXPRESSION; TARGET in [Van Zandt, Michael C.; Jagdmann, G. Erik; Whitehouse, Darren L.; Ji, Minkoo; Savoy, Jennifer] New England Discovery Partners, 23 Business Pk Dr, Branford, CT 06405 USA; [Potapova, Olga; Pyle, Anna Marie] Yale Univ, Howard Hughes Med Inst, Dept Mol Cellular & Dev Biol, 219 Prospect St, New Haven, CT 06511 USA; [Potapova, Olga; Pyle, Anna Marie] Yale Univ, Howard Hughes Med Inst, Dept Chem, 219 Prospect St, New Haven, CT 06511 USA; [Cousido-Siah, Alexandra; Mitschler, Andre; Podjarny, Alberto D.] Univ Strasbourg, INSERM, CNRS, Dept Integrat Biol,IGBMC, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France; [Howard, Eduardo I.] Consejo Nacl Invest Cient & Tecn, Inst Fis Liquidos & Sistemas Biol IFLYSIB, Calle 59 Numero 789, RA-1900 La Plata, Buenos Aires, Argentina in 2019.0, Cited 31.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Recent efforts to identify new highly potent arginase inhibitors have resulted in the discovery of a novel family of (3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid analogues with up to a 1000-fold increase in potency relative to the current standards, 2-amino-6-boronohexanoic acid (ABH) and N-hydroxy-nor-L-arginine (nor-NOHA). The lead candidate, with an N-2-amino-3-phenylpropyl substituent (NED-3238), example 43, inhibits arginase I and II with IC50 values of 1.3 and 8.1 nM, respectively. Herein, we report the design, synthesis, and structure activity relationships for this novel series of inhibitors, along with X-ray crystallographic data for selected examples bound to human arginase II.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Van Zandt, MC; Jagdmann, GE; Whitehouse, DL; Ji, M; Savoy, J; Potapova, O; Cousido-Siah, A; Mitschler, A; Howard, EI; Pyle, AM; Podjarny, AD or concate me.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article 5-endo-dig Cyclization of O-Propargyl Mandelic Acid Amides towards 2,5-Dihydrofurans WOS:000500575800001 published article about MOLECULAR-ORBITAL METHODS; FORMAL 4+1 CYCLOADDITION; GAUSSIAN-TYPE BASIS; STEREOCONTROLLED SYNTHESIS; ALLYLIC SUBSTITUTION; ASYMMETRIC-SYNTHESIS; GOLD CATALYSIS; CYCLOISOMERIZATION; ALCOHOLS; ETHERS in [Ben Gaied, Lilia] Inst Preparatoire Etud Sci & Tech, Lab Physicochim Microstruct & Microsyst, BP 51, Tunis 2070, Tunisia; [Fincias, Nicolas; Garrec, Julian; El Kaim, Laurent] Inst Polytech Paris, LSO, Ecole Polytech, CNRS,ENSTA Paris UMR 7652, 828 Bd Marechaux, F-91128 Palaiseau, France in 2019.0, Cited 71.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

5-endo-dig cyclization of O-propargyloxyamides, obtained through a Passerini reaction mediated by boric acid and subsequent propargylation, affords 2,5-dihydrofurans in the presence of tert-butylate. The mechanism of the reaction was studied by using DFT calculations and the results were compared with the behavior of analogous N-propargylamide derivatives.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Ben Gaied, L; Fincias, N; Garrec, J; El Kaim, L or concate me.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Cell cycle arrest and induction of apoptosis of newly synthesized pyranoquinoline derivatives under microwave irradiation WOS:000464742900005 published article about ANTITUMOR ACTIVITIES; IN-VITRO; CONSTITUENTS; ALKALOIDS; QUINOLINE; ACIDS; ASSAY in [Fouda, Ahmed M.; Youssef, Ayman M. S.] King Khalid Univ, Fac Sci, Chem Dept, Abha 61413, Saudi Arabia; [Youssef, Ayman M. S.] Fayoum Univ, Fac Sci, Chem Dept, Al Fayyum, Egypt; [Afifi, Tarek H.] Taibah Univ, Fac Sci, Chem Dept, Al Madinah Al Munawarah 30002, Saudi Arabia; [Mora, Ahmed; El-Agrody, Ahmed M.] Al Azhar Univ, Fac Sci, Chem Dept, Nar City 11884, Cairo, Egypt in 2019, Cited 47. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Name: 3-Pyridinecarboxaldehyde

A set of 2-amino-4-aryl-4H-pyrano[3,2-h]quinoline-3-carbonitrile derivatives were prepared via a one-pot, three-component condensation reaction between the substituted hydroxyquinoline derivatives, some aryl and/or hetaryl aldehydes, and malononitrile in an ethanol/piperidine solution in a microwave irradiation environment. The structure of the prepared compounds was instituted on the foundations of their spectral data: IR, H-1 NMR, C-13 NMR, and MS. Four human cancer cell lines, MCF-7, HCT-116, HepG-2, and A549 were utilized to evaluate the antiproliferative properties of the target compounds in comparison to the positive controls, Vinblastine and Colchicine using the MTT viability assay. The cell cycle arrest behavior, detected by propidium iodide as well as the apoptosis induction, which was monitored by the flow cytometer, using the Annexin V-FITC kits, was investigated. The results illustrated that the potent cytotoxic compounds induce cell cycle arrest at the G2/M phases and trigger apoptosis in the different tested cancer cells. Finally, the structure-activity relationship (SAR) study showcases the substitution of some specific groups at the 4-, 6-, and 9-positions in the prepared 2-amino-4H-pyrano[3,2-h]quinoline derivatives, which indicates that the lipophilicity manipulates the ability of these moieties against the diverse cell lines.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Fouda, AM; Youssef, AMS; Afifi, TH; Mora, A; El-Agrody, AM or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, biological evaluation, and structure activity relationship (SAR) study of pyrrolidine amide derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors WOS:000459510800006 published article about RAT MODEL; POTENT; PALMITOYLETHANOLAMIDE; ACTIVATION; DESIGN; ESTERS; FAAH; PPAR in [Zhou, Pan; Ren, Jie; Qiu, Yan] Xiamen Univ, Eye Inst, Xiamen 361102, Fujian, Peoples R China; [Zhou, Pan; Xiang, Lei; Ren, Jie; Qiu, Yan] Xiamen Univ, Med Coll, Xiamen 361102, Fujian, Peoples R China; [Zhao, Dongsheng] Quanzhou Med Coll, Dept Pharm, Tel Quanzhou 362100, Peoples R China; [Li, Yuhang] Chinese Acad Sci, Haixi Inst, Xiamen Inst Rare Earth Mat, Xiamen 361005, Fujian, Peoples R China; [Li, Yuhang] Chinese Acad Sci, Fujian Inst Res Struct Matter, CAS Key Lab Design & Assembly Funct Nanostruct, Beijing, Peoples R China; [Li, Yuhang] Chinese Acad Sci, Fujian Inst Res Struct Matter, Fujian Prov Key Lab Nanomat, Beijing, Peoples R China in 2019.0, Cited 33.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 500-22-1

N-Acylethanolamine acid amidase (NAAA) is one of the key enzymes involved in the degradation of fatty acid ethanolamides (FAEs), especially for palmitoylethanolamide (PEA). Pharmacological blockage of NAAA restores PEA levels, providing therapeutic benefits in the management of inflammation and pain. In the current work, we showed the structure-activity relationship (SAR) studies for pyrrolidine amide derivatives as NAAA inhibitors. A series of aromatic replacements or substituents for the terminal phenyl group of pyrrolidine amides were examined. SAR data showed that small lipophilic 3-phenyl substituents were preferable for optimal potency. The conformationally flexible linkers increased the inhibitory potency of pyrrolidine amide derivatives but reduced their selectivity toward fatty acid amide hydrolase (FAAH). The conformationally restricted linkers did not enhance the inhibitor potency toward NAAA but improved the selectivity over FAAH. Several low micromolar potent NAAA inhibitors were developed, including 4g bearing a rigid 4-phenylcinnamoyl group. Dialysis and kinetic analysis suggested that 4g inhibited NAAA via a competitive and reversible mechanism. Furthermore, 4g showed high anti-inflammatory activities in lipopolysaccharide (LPS) induced acute lung injury (ALI) model, and this effect was blocked by pre-treatment with the PPAR-a antagonist MK886. We anticipate that 4g (E93) will enable a new agent to treat inflammation and related diseases.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhou, P; Xiang, L; Zhao, DS; Ren, J; Qiu, Y; Li, YH or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. Guo, L; Ma, Q; Chen, W; Fan, WX; Zhang, J; Dai, B in [Guo, Liang; Zhang, Jie; Dai, Bin] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn XinJiang Bingtuan, Shihezi 832000, Peoples R China; [Ma, Qin; Chen, Wei; Fan, Wenxi] XinJiang Huashidan Pharmaceut Res Co Ltd, Urumqi, Peoples R China published Synthesis and biological evaluation of novel N-9-heterobivalent beta-carbolines as angiogenesis inhibitors in 2019.0, Cited 34.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A series of novel N-9-heterobivalent beta-carbolines has been synthesized. All the novel compounds were tested for their anticancer activity against six tumour cell lines in vitro. Among these molecules, compounds 5b, and 5w exhibited strong cytotoxic activities with IC50 value of lower than 20 mu M. Acute toxicities and antitumor efficacies of the selected compounds in mice were also evaluated, compounds 5b and 5w exhibited that tumour inhibition rate of over 40% in the Sarcoma 180 and Lewis lung cancer animal models. Preliminary structure-activity relationships (SARs) analysis indicated that: (1) C-1-methylation and C-7-methoxylation were favorable for increased activities; (2) 3-Pyridyl or 2-thienyl group substituent into position-1 of the beta-carboline core, and the aryl substituent into another beta-carboline ring might be detrimental to cytotoxic effects of this class compounds. Investigation of the preliminary mechanism of action demonstrated that compound 5b had obvious angiogenesis inhibitory effects in the chicken chorioallantoic membrane (CAM) assay.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Guo, L; Ma, Q; Chen, W; Fan, WX; Zhang, J; Dai, B or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Grignard reagents-catalyzed hydroboration of aldehydes and ketones WOS:000526118900004 published article about SOLVENT-FREE HYDROBORATION; COMPLEXES SYNTHESES; MAGNESIUM in [Wang, Weifan; Lu, Kai; Qin, Yi; Xu, Li; Ma, Mengtao] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Peoples R China; [Yao, Weiwei; Yuan, Dandan] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China; [Pullarkat, Sumod A.] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore in 2020.0, Cited 43.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

Simple, commercially available Grignard reagents have been used as highly efficient precatalysts for the hydroboration of a wide range of aldehydes and ketones. The reaction employs very low catalyst loadings (aldehydes: 0.05 mol%, ketones: 0.5 mol%), and proceeds rapidly (aldehydes: 10 min, ketones: 20 min) under neat condition at room temperature. The Grignard reagent catalyst demonstrated good substrate scope, functional group tolerance, and high chemoselectivity in the carbonyl hydroboration. DFT calculations were performed to investigate the possible reaction mechanism. In contrast to the traditional stoichiometric use of Grignard reagents, this newly developed protocol provides a catalytic application of these reagents for molecular transformations. (C) 2020 Elsevier Ltd. All rights reserved.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, WF; Lu, K; Qin, Y; Yao, WW; Yuan, DD; Pullarkat, SA; Xu, L; Ma, MT or concate me.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Palladium-Catalyzed Formal Hydroalkylation of Aryl-Substituted Alkynes with Hydrazones WOS:000555569300042 published article about C-H BONDS; OLEFIN SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; INTERNAL ALKYNES; ALDEHYDES; ALKENYLATION; CARBANIONS; 1,3-DIENES; ALCOHOLS; ALKENES in [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Qiu, Zihang; Chen, Zhangpei; Liang, Yu-Feng; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Yu, Lin; Lv, Leiyang; Tan, Ze] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China in 2020.0, Cited 62.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

We have developed an unprecedented Pd-catalyzed formal hydroalkylation of alkynes with hydrazones, which are generated in situ from naturally abundant aldehydes, as both alkylation reagents and hydrogen donors. The hydroalkylation proceeds with high regio- and stereoselectivity to form (Z)-alkenes, which are more difficult to generate compared to (E)-alkenes. The reaction is compatible with a wide range of functional groups, including hydroxy, ester, ketone, nitrile, boronic ester, amine, and halide groups. Furthermore, late-stage modifications of natural products and pharmaceutical derivatives exemplify its unique chemoselectivity, regioselectivity, and synthetic applicability. Mechanistic studies indicate the possible involvement of Pd-hydride intermediates.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Yu, L; Lv, LY; Qiu, ZH; Chen, ZP; Tan, Z; Liang, YF; Li, CJ or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 500-22-1. Magalhaes, J; Franko, N; Annunziato, G; Pieroni, M; Benoni, R; Nikitjuka, A; Mozzarelli, A; Bettati, S; Karawajczyk, A; Jirgensons, A; Campanini, B; Costantino, G in [Magalhaes, Joana; Annunziato, Giannamaria; Pieroni, Marco; Costantino, Gabriele] Univ Parma, Dept Food & Drug, Grp P4T, Parma, Italy; [Franko, Nina; Benoni, Roberto; Mozzarelli, Andrea; Bettati, Stefano; Campanini, Barbara] Univ Parma, Dept Food & Drug, Lab Biochem & Mol Biol, Parma, Italy; [Nikitjuka, Anna; Jirgensons, Aigars] Latvian Inst Organ Synth, Riga, Latvia; [Mozzarelli, Andrea] Natl Inst Biostruct & Biosyst, Rome, Italy; [Mozzarelli, Andrea] Inst Biophys, Pisa, Italy; [Bettati, Stefano] Univ Parma, Dept Neurosci, Parma, Italy; [Karawajczyk, Anna] Selvita SA, Pk Life Sci, Krakow, Poland; [Costantino, Gabriele] Univ Parma, Ctr Interdipartimentale Misure CIM G Casna, Parma, Italy published Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms in 2019.0, Cited 33.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibitors of enzymes that synthesise cysteine and belong to the reductive sulphur assimilation pathway, absent in mammals. Previous studies have provided a novel series of inhibitors for O-acetylsulfhydrylase – a key enzyme involved in cysteine biosynthesis. Despite displaying nanomolar affinity, the most active representative of the series was not able to interfere with bacterial growth, likely due to poor permeability. Therefore, we rationally modified the structure of the hit compound with the aim of promoting their passage through the outer cell membrane porins. The new series was evaluated on the recombinant enzyme from Salmonella enterica serovar Typhimurium, with several compounds able to keep nanomolar binding affinity despite the extent of chemical manipulation.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Magalhaes, J; Franko, N; Annunziato, G; Pieroni, M; Benoni, R; Nikitjuka, A; Mozzarelli, A; Bettati, S; Karawajczyk, A; Jirgensons, A; Campanini, B; Costantino, G or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article 4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis WOS:000457961800001 published article about MONOAMINE-OXIDASE-B; HIGH-POTENCY; IN-VITRO; MAO; SCAFFOLD; DESIGN; AGENTS; IDENTIFICATION in [Secci, Daniela; Guglielmi, Paolo; D’Ascenzio, Melissa; Chimenti, Paola] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, Rome, Italy; [Carradori, Simone] G DAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Sch Pharm, Pharmaceut Chem, Potchefstroom, South Africa; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa; [Bagetta, Donatella; Alcaro, Stefano; Ortuso, Francesco] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Catanzaro, Italy; [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey; [D’Ascenzio, Melissa] Univ Dundee, Sch Life Sci, DArcy Thompson Unit, Dundee DD1 4HN, Scotland in 2019.0, Cited 51.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Name: 3-Pyridinecarboxaldehyde

A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure-activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Secci, D; Carradori, S; Petzer, A; Guglielmi, P; D’Ascenzio, M; Chimenti, P; Bagetta, D; Alcaro, S; Zengin, G; Petzer, JP; Ortuso, F or concate me.. Name: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Shendy, SA; Shahverdizadeh, GH; Babazadeh, M; Hosseinzadeh-Khanmiri, R; Es’haghi, M in [Shendy, Saeid Ahmadizadeh; Shahverdizadeh, Gholam Hossein; Babazadeh, Mirzaagha; Hosseinzadeh-Khanmiri, Rahim; Es’haghi, Moosa] Islamic Azad Univ, Dept Chem, Tabriz Branch, Tabriz, Iran published Preparation and Characterization of Acetic Acid-Functionalized Fe3O4@SiO2 Nanoparticles as an Efficient Nanocatalyst for the Synthesis of Nitrones in Water in 2020.0, Cited 37.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Magnetic materials grafted with acetic acid (Fe3O4@SiO2COOH MNPs) were successfully prepared from the incorporation of bromoacetic acid as a functional group on the surface of magnetite silica nanoparticles. The catalyst has been characterized by Fourier transform infrared spectroscopy, X-ray diffraction, elemental analysis, energy-dispersive X-ray spectroscopy, thermogravimetric analysis, scanning electron microscopy and transition electron microscopy. Next, the efficiency of this acid catalyst was examined for the synthesis of the nitrones from diaminoglyoxime in the water at room temperature. The present approach provides several advantages such as environmentally benign, excellent yields, straightforward, short reaction times, good recyclability of catalyst, cost-effective and facile catalyst separation for the preparation of nitrones compounds as an important privileged medicinal scaffold.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Shendy, SA; Shahverdizadeh, GH; Babazadeh, M; Hosseinzadeh-Khanmiri, R; Es’haghi, M or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem