Synthetic Route of 50735-34-7, Adding some certain compound to certain chemical reactions, such as: 50735-34-7, name is Methyl 2-amino-5-bromopyridine-3-carboxylate,molecular formula is C7H7BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50735-34-7.
A mixture of methyl 2-amino-5-bromonicotinate (1 g, 4.33 mmol), 4,4,4′,4′,5,5,5′,5′- octamethyl-2,2′-bi(1,3,2-dioxaborolane) (1.319 g, 5.19 mmol), potassium acetate (1.274 g, 12.98 mmol) in dioxane (20 mL) was degassed (3 x) with vacuum/nitrogen.1,1′- Bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (0.353 g, 0.433 mmol) was added, and the mixture was degassed (2 x) and filled with N2. The reaction mixture was immersed in an oil bath at 80 C and stirred ON. The mixture was diluted with ethyl acetate, and washed with water and brine. The organic layer was collected, and the aqueous layers were sequentially extracted with ethyl acetate (2 x). The combined organic layers were dried over anhydrous sodium sulfate and concentrated. After purification by Biotage flash chromatography (40 g column; 0% – 100% ethyl acetate in hexane), the obtained product was triturated with ether to afford methyl 2- amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate (0.6 g, 2.157 mmol, 49.8 % yield) as a light tan solid. (0645) MS ESI m/z 279.18 (M+H)
According to the analysis of related databases, 50735-34-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; DZIERBA, Carolyn Diane; GONG, Hua; GUERNON, Jason M.; GUO, Junqing; HART, Amy C.; LUO, Guanglin; MACOR, John E.; PITTS, William J.; SHI, Jianliang; VENABLES, Brian Lee; WEIGELT, Carolyn A.; WU, Yong-Jin; ZHENG, Zhizhen Barbara; SIT, Sing-Yuen; CHEN, Jie; (810 pag.)WO2019/147782; (2019); A1;,
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