Related Products of 53710-17-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53710-17-1, name is 2,6-Diiodopyridine, molecular formula is C5H3I2N, molecular weight is 330.89, as common compound, the synthetic route is as follows.
To a solution of 25 mmol of 20 in 80 mL of dry THF at 0 C was added 25 mmol of KH (30% mineral oil) under N2. The suspension was stirred for 20 min before 10 mmol of 15 in 20 mL of dry THF was added over a period of 10 min. The resulting mixture was stirred for two days at 60 C under N2. The reaction was quenched dropwise with isopropanol (10 mL) and saturated NaCI (50 mL) at 0 C and the mixture was diluted with 200 mL of ethyl acetate. After separating the two phases, the organic phase was washed with saturated NaCl, dried over MgS04, and concentrated under reduced pressure to give 10 mmol of 21. ¹H NMR (300 MHz, DMSO-d6) 8 8.92 (d, J = 2.1 Hz, 2H), 8.11 (t, J = 7.8 Hz, 1H), 7.84 (d, J = 0.9 Hz, 2H), 7.79 (d, J = 8.0 Hz, 2H), 6.61 (dd, J1 = 2.8 Hz, J2 = 0.9 Hz, 2H) ; MS m/z: 212 (M + 1).
Statistics shows that 53710-17-1 is playing an increasingly important role. we look forward to future research findings about 2,6-Diiodopyridine.
Reference:
Patent; ICAGEN, INC.; ASTELLAS PHARMA INC.; WO2005/100349; (2005); A2;,
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