Category: 54864-83-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54864-83-4, name is 6-Chloro-N,N-dimethylnicotinamide, the common compound, a new synthetic route is introduced below. Computed Properties of C8H9ClN2O

1 -(4-/Lery-Butylphenyl)-6-chloro-2-ethoxycarbonylmethyl-5-hydroxyindole-3- carboxylic acid ethyl ester (120 mg, 0.26 mmol, see step (b) above), 6-chloro-Lambda^7V- dimethylriicotinamide (72 mg, 0.39 mmol), K2CO3 (181 mg, 1.31 mmol) and DMF (3 mL) was heated at 115 0C for 96 h and filtered through Celite. The solids were washed with EtOAc and the combined filtrates concentrated and purified by chromatography to give the sub-title compound. Yield 48 mg (78%).

The synthetic route of 54864-83-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOLIPOX AB; WO2006/77366; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54864-83-4, name is 6-Chloro-N,N-dimethylnicotinamide, the common compound, a new synthetic route is introduced below. Computed Properties of C8H9ClN2O

1 -(4-/Lery-Butylphenyl)-6-chloro-2-ethoxycarbonylmethyl-5-hydroxyindole-3- carboxylic acid ethyl ester (120 mg, 0.26 mmol, see step (b) above), 6-chloro-Lambda^7V- dimethylriicotinamide (72 mg, 0.39 mmol), K2CO3 (181 mg, 1.31 mmol) and DMF (3 mL) was heated at 115 0C for 96 h and filtered through Celite. The solids were washed with EtOAc and the combined filtrates concentrated and purified by chromatography to give the sub-title compound. Yield 48 mg (78%).

The synthetic route of 54864-83-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOLIPOX AB; WO2006/77366; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 54864-83-4, name is 6-Chloro-N,N-dimethylnicotinamide, the common compound, a new synthetic route is introduced below. Computed Properties of C8H9ClN2O

1 -(4-/Lery-Butylphenyl)-6-chloro-2-ethoxycarbonylmethyl-5-hydroxyindole-3- carboxylic acid ethyl ester (120 mg, 0.26 mmol, see step (b) above), 6-chloro-Lambda^7V- dimethylriicotinamide (72 mg, 0.39 mmol), K2CO3 (181 mg, 1.31 mmol) and DMF (3 mL) was heated at 115 0C for 96 h and filtered through Celite. The solids were washed with EtOAc and the combined filtrates concentrated and purified by chromatography to give the sub-title compound. Yield 48 mg (78%).

The synthetic route of 54864-83-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIOLIPOX AB; WO2006/77366; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 54864-83-4 ,Some common heterocyclic compound, 54864-83-4, molecular formula is C8H9ClN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6-((3S)-3-{[(4-Hydroxy-l-adamantyl)carbonyl]amino}piperidin-l-yl)-N,N-dimethylnicotinamideA mixture of 4-hydroxy-N-[(3S)-piperidin-3-yl]adamantane-l-carboxamide (13.9 mg, 0.0000500 mol, prepared by using a procedure that was analogous to that described for the synthesis of example 141, steps 1-3), 6-chloro-N,N-dimethylnicotinamide (13.8 mg, 0.0000750 mol) andN,N-diisopropylethylamine (19.4 mg, 0.000150 mol) in N,N-dimethylformamide (0.500 mL, 0.00646 mol) was irradiated under microwave at 120 C for 10 min. The mixture was adjusted with TFA to pH =2.0 and was diluted with methanol (0.8 mL). The resulting solution was purified by prep.-HPLC to give the desired product. LCMS: (M + H)+ = 427.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,54864-83-4, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; WO2006/20598; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem