Electric Literature of 54916-65-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54916-65-3, name is 5-Chloro-2-methoxynicotinic acid, molecular formula is C7H6ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-Chloro-2-methoxy-pyridine-3 -carboxylic acid (182 mg, 0.97 mmol) and 6-[4-[(lS)- 2,2,2-trifluoro-l-methyl-ethyl]-l,2,4-triazol-3-yl]pyridin-2-amine (250 mg, 0.97 mmol) were dissolved in triethylamine (1.35 mL, 9.72 mmol). Propylphosphonic anhydride (> 50 wt % in EtOAc, 1.0 mL) was added and the reaction was heated at 80 C for 3 h. The reaction was cooled to rt, quenched by addition of MeOH (5 mL) and stirred for 1 h. The resulting solid was filtered and dried under vacuum to give the title compound (200 mg, 48 %) as a white solid. 1H NMR (400 MHz, CDCI3) d 10.37 (s, 1H), 8.58 (d, 7=2.51 Hz, 1H), 8.43 – 8.49 (m, 2H), 8.31 (d, 7=2.51 Hz, 1 H), 8.16 (dd, 7=0.75, 7.78 Hz, 1H), 7.95 (t, 7=7.91 Hz, 1H), 6.71 (quin, 7=7.22 Hz, 1H), 4.19 (s, 3H), 1.82 (d, 7=7.28 Hz, 3H). MS (ESI): 427.0 [M + H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 54916-65-3, 5-Chloro-2-methoxynicotinic acid.
Reference:
Patent; BIOGEN MA INC.; GONZALEZ LOPEZ DE TURISO, Felix; DECHANTSREITER, Michael; XIN, Zhili; JONES, John, H.; HIMMELBAUER, Martin; (0 pag.)WO2020/6031; (2020); A1;,
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