Category: 55876-82-9

Adding a certain compound to certain chemical reactions, such as: 55876-82-9, Ethyl 5-methylpicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55876-82-9, blongs to pyridine-derivatives compound. SDS of cas: 55876-82-9

Synthesis Example 2 2-Carboxy-5-methylpyridinium chloride STR25 78.1 g of the crude product of the ethyl 5-methylpyridine-2-carboxylate obtained in Synthesis Example 1 was dissolved in 200 ml of 6N-hydrochloric acid, followed by heating under reflux for 16 hours. The reaction solution was concentrated in a reduced pressure. Then, acetonitrile was added to the residue, and the white crystal thus precipitated was recovered by filtration, washed with acetonitrile and dried at 90 C. to give 26.3 g of the title compound. Yield 37%. 1H-NMR (400 MHz, CDCl3) delta; 8.51 (1H, m), 8.37 (1H, m), 8.21 (1H, d, J=8.0 Hz), 2.42 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55876-82-9, its application will become more common.

Reference:
Patent; Eisai Co., Ltd.; US5789403; (1998); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55876-82-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55876-82-9, name is Ethyl 5-methylpicolinate. A new synthetic method of this compound is introduced below.

To a solution of methyl 5-methylpyridine-2-carboxylate [Example 2, Step 1] (3 g, 18.3 mmol, 1.00 equiv) in ethanol (20 mL) and tetrahydrofuran (20 mL) was added CaCl2 (8.125 g, 549 mmol 4.00 equiv) and NaBH4 (1.38 g, 36.6 mmol, 2.00 equiv). The resulting solution was stirred overnight at 50 C. The solids were filtered out. The filtrate was concentrated under vacuum. The resulting solution was diluted with ethyl acetate (50 mL). The solids were filtered out. The filtrate was concentrated under vacuum to afford 2.6 g (88.9%) of (5-methylpyridin-2-yl)methanol as light yellow oil. LC-MS: m/z=124[M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55876-82-9, Ethyl 5-methylpicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Auspex Pharmaceuticals, Inc.; ZHANG, Chengzhi; (94 pag.)US2018/79742; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55876-82-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55876-82-9, name is Ethyl 5-methylpicolinate. A new synthetic method of this compound is introduced below.

To a solution of methyl 5-methylpyridine-2-carboxylate [Example 2, Step 1] (3 g, 18.3 mmol, 1.00 equiv) in ethanol (20 mL) and tetrahydrofuran (20 mL) was added CaCl2 (8.125 g, 549 mmol 4.00 equiv) and NaBH4 (1.38 g, 36.6 mmol, 2.00 equiv). The resulting solution was stirred overnight at 50 C. The solids were filtered out. The filtrate was concentrated under vacuum. The resulting solution was diluted with ethyl acetate (50 mL). The solids were filtered out. The filtrate was concentrated under vacuum to afford 2.6 g (88.9%) of (5-methylpyridin-2-yl)methanol as light yellow oil. LC-MS: m/z=124[M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,55876-82-9, Ethyl 5-methylpicolinate, and friends who are interested can also refer to it.

Reference:
Patent; Auspex Pharmaceuticals, Inc.; ZHANG, Chengzhi; (94 pag.)US2018/79742; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem