Category: 56187-37-2

Application of 56187-37-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56187-37-2, name is 2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetic acid. A new synthetic method of this compound is introduced below.

In a dry reaction flask, 137.66 g of 3,5-dichloro-4-pyridone-1-acetic acid (0.62 mol) and 222.64 gDibenzothiazyl disulfide (DM, 0.6696 mol) was dissolved in 500 mL of dichloromethane and 54 g (0.682 mol) of pyridine was added.The reaction was stirred at room temperature for 1 hour, and then an aqueous solution of triethyl phosphite (118.47 g of triethyl phosphite dissolved in 150 mL of methylene chloride, 0.713 mol) was added dropwise slowly.1-2 hours dropwise addition is complete, the reaction temperature was controlled at 20-25 C for 1-2 hours, filtered and the filtrate cooled down to below 10 C,Crystals were precipitated, suction filtered and dried to give 234.8 g of cefoxitin side chain acid active ester (0.6063 mol). The yield was 97.1% and the HPLC purity was 99.3%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56187-37-2, 2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetic acid, and friends who are interested can also refer to it.

Reference:
Patent; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Wang Jun; Zuo Cuiyong; Gao Feifei; (10 pag.)CN105017286; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56187-37-2, 2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

200ml of toluene and 2-iodophenylboronic acid (0.21mol) were added to a clean reaction flask, then compound IV210.93g (1.06mol) was added, and then compound III327.21g (0.95mol) was slowly added, and the reaction was refluxed for 5-6h, After the reaction, cooled to room temperature, transferred to purified water, separated the solid and filtered, washed with purified water, recrystallized with ethanol, and dried under vacuum to obtain 484.55 g of cefoxidone (I), with a molar yield of 93% and a purity of 99.9 %,Maximum single impurity 0.04%

The synthetic route of 56187-37-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Shandong Luoxin Pharmaceutical Group Co., Ltd.; Shandong Yuxin Pharmaceutical Co., Ltd.; Liu Zhenteng; Liang Zhen; Liu Jiang; Liu Qingli; Zhang Jiwen; (6 pag.)CN110563750; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem