Category: 5969-83-5

Related Products of 5969-83-5 ,Some common heterocyclic compound, 5969-83-5, molecular formula is C11H8ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: 2-Phenylpyridine (77.5 mg, 0.5 mmol, 1 eq), RuCl3 (2.6 mg, 0.0125 mmol, 5 mol%), FeCl3. 6 H2O (108 mg, 0.4 mmol) and [BuEt3N][NTf2] (15) (0.5 mL) were added under an atmosphere of air to a 10 ml round bottom flask. The reaction was stirred for 48 h at 110 C. After completion of the reaction, it was cooled to room temperature and then ethyl acetate (1 mL) and triethylamine (1 mL) were added and the mixture was allowed to stir for 30 min. The purification was performed by flash chromatography (diethyl ether/ n-hexane = 1 : 1) to afford 2 (64 mg, 21 mmol, 83 %).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5969-83-5, 2-(4-Chlorophenyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Muntzeck, Maren; Pippert, Felix; Wilhelm, Rene; Tetrahedron; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 5969-83-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5969-83-5, name is 2-(4-Chlorophenyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: In a typical reaction, a 10 mL oven-dried reaction vessel was charged with Pd/MgLa mixed oxide (30 mg), 2-phenylpyridine (29 mg, 0.2 mmol), benzyl alcohol (108 mg, 1 mmol), tert-butyl hydroperoxide (70% solution in water, ?129 mg, 1 mmol) and chlorobenzene (0.5 mL) were added. The resulting solution was stirred at 120 C for 8 h in open air. The reaction was monitored by thin-layer chromatography (TLC). After cooling to room temperature, catalyst was separated by simple centrifugation. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography using silica gel and a mixture of hexane/ethyl acetate as eluents. All the products were confirmed by 1H NMR and 13C NMR spectroscopy. The recovered catalyst was used for the next cycle without any further purification.

According to the analysis of related databases, 5969-83-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kishore; Kantam, M. Lakshmi; Yadav; Sudhakar; Laha; Venugopal; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 213 – 218;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5969-83-5, 2-(4-Chlorophenyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(4-Chlorophenyl)pyridine, blongs to pyridine-derivatives compound. name: 2-(4-Chlorophenyl)pyridine

General procedure: A mixture of aryl halide (0.5 mmol), phenylboronic acid(0.5 mmol), K2CO3 (0.5 mmol), and nano-Pd/Fe3O4/ZnO(0.003 g, contain 9.7 × 10-5 mol% Pd), and H2O (1 mL) was stirred at 100 C in an oil bath under air atmosphere. After completion of the reaction, the catalyst was removed by a magnet and the resulting mixture was quenched with water and extracted with EtOAc (2 × 10 mL). The combined organic layer was dried over anhydrous sodium sulfate(Na2SO4) and evaporated in a rotary evaporator under reduced pressure. Resulting product was purified by column chromatography on silica gel using n-hexane/ethylacetate (5:1) as eluent to afford the pure product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5969-83-5, 2-(4-Chlorophenyl)pyridine, and friends who are interested can also refer to it.

Reference:
Article; Hosseini-Sarvari, Mona; Khanivar, Ameneh; Moeini, Fatemeh; Journal of the Iranian Chemical Society; vol. 13; 1; (2016); p. 45 – 53;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem