Reference of 610278-88-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.610278-88-1, name is 3,5-Dichloro-2-nitropyridine, molecular formula is C5H2Cl2N2O2, molecular weight is 192.9876, as common compound, the synthetic route is as follows.
b) 5′-Chloro-4-methyl-2′-nitro-3,4,5,6-tetrahydro-2H-[l,3′]bipyridinyl; A mixture of 3,5-dichloro-2-nitropyridine (193 mg, 1.00 mmol), A- methylpiperidine (118 muL, 1.00 mmol) and K2CO3 (138 mg, 1.00 mmol) in toluene (10 mL) was heated at 50 C for 3h. Toluene was removed in vacuo and the residue obtained was purified on silica (2 % EtOAc/ hexane) to obtain the title compound (153 mg, 60%). 1H-NMR (CDCl3; 400 MHz): delta 7.95 (s, IH, J=2.5 Hz), 7.58 (s, IH, J=2.5 Hz), 3.30 (m, 2H), 2.95 (m, 2H), 1.87 (m, 2H), 1.65 (m, IH), 1.35 (m, 2H), 1.0 (d, 3H, J=6.3 Hz).
Statistics shows that 610278-88-1 is playing an increasingly important role. we look forward to future research findings about 3,5-Dichloro-2-nitropyridine.
Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2006/47504; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem