Related Products of 614750-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.614750-84-4, name is 6-Iodo-[1,2,4]triazolo[1,5-a]pyridine, molecular formula is C6H4IN3, molecular weight is 245.02, as common compound, the synthetic route is as follows.
To a solution of 6-iodo[l,2,4]triazolo[l,5-a]pyridme (5 g, 0.02 mol, prepared according to literature procedure) in anhydrous THF (300 mL), was slowly added IM of isopropylmagnesium bromide in THF (31 mL, 0.03 mol) at 0 oC. It was stirred at OoC for 1 hour and then was added anhydrous DMF (6 mL, 0.05 mol). It was allowed to warm to room temperature and stirred for overnight. It was then quenched with 100 mL of water and worked up with diethyl ether and saturated NaHCO3. Dried over MgSO4 and concentrated. The residue was purified on silica gel column with EtOAc to give the desire product as a tan solid (3g, 100percent). LC-MS/ES+: M+l: 148.0.
Statistics shows that 614750-84-4 is playing an increasingly important role. we look forward to future research findings about 6-Iodo-[1,2,4]triazolo[1,5-a]pyridine.
Reference:
Patent; BIOGEN IDEC MA INC; WO2006/26305; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem