Reference of 62476-56-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62476-56-6, name is 3-Amino-2,6-dichloropyridine, molecular formula is C5H4Cl2N2, molecular weight is 163.01, as common compound, the synthetic route is as follows.
69.2 g of homemade 2,6-dichloro-3-aminopyridine was added.3.6g of tetraethylammonium chloride and 207g of 30% industrial hydrochloric acid, cooling to below 0 C,117.2 g of 30% sodium nitrite solution was added dropwise, and the dropwise addition was completed to prepare a diazonium salt solution, which was kept at about 0 C for use. At room temperature, 8.4 g of cuprous chloride and 207 g were added to the reactor.30% industrial hydrochloric acid, under the protection of nitrogen, start to add diazonium salt solution of about 0 C.At the end of the dropwise addition, the temperature was gradually raised to 60-70 C, and the reaction was carried out for about 2 h.After completion of the reaction, the reaction solution was extracted with dichloromethane, and the organic layer was concentrated to give crude 2,3,6-trichloropyridine. Then, toluene and petroleum ether were recrystallized to obtain 71.3 g of a white crystal, a content of 98%, and a crude yield of 92%.
Statistics shows that 62476-56-6 is playing an increasingly important role. we look forward to future research findings about 3-Amino-2,6-dichloropyridine.
Reference:
Patent; Anhui Guoxing Biochemical Co., Ltd.; Liu Shanhe; Wen Lanlan; Fu Shenghui; Zhang Lingwei; Jiang Wei; (8 pag.)CN108484492; (2018); A;,
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