636-73-7 | Page 12 of 24 | Pyridine-derivatives

Lee, Hon Cheung’s team published research in Journal of Biological Chemistry in 272 | CAS: 636-73-7

Journal of Biological Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Name: Pyridine-3-sulfonic acid.

Lee, Hon Cheung published the artcileStructural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity, Name: Pyridine-3-sulfonic acid, the publication is Journal of Biological Chemistry (1997), 272(33), 20378-20383, database is CAplus and MEDLINE.

Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes Ca²⁺ through a mechanism totally independent of cyclic ADP-ribose or inositol trisphosphate. The structural determinants important for its Ca²⁺ release activity were investigated using a series of analogs. It is shown that changing the 3-carboxyl group of the nicotinic acid (NA) moiety in NAADP to either an uncharged carbinol or from the 3-position to the 4-position of the pyridine ring totally eliminates the Ca²⁺ release activity. Conversion of the 3-carboxyl to other neg. charged groups, either 3-sulfonate, 3-acetate, or 3-quinoline carboxylate, retains the Ca²⁺ release activity, although their half-maximal effective concentrations (EC₅₀) are 100-200-fold higher. Changing the 6-amino group of the adenine to a hydroxyl group results in more than a 1000-fold decrease in the Ca²⁺ release activity. Conversion of the 2′-phosphate to 2′,3′-cyclic phosphate or 3′-phosphate likewise increases the EC₅₀ by about 5- and 20-fold, resp. Similar to NAADP, all of the active analogs can also desensitize the Ca²⁺ release mechanism at subthreshold concentrations, suggesting that this novel property is intrinsic to the release mechanism. The series of analogs used was produced by using ADP-ribosyl cyclase to catalyze the exchange of the nicotinamide group of various analogs of NADP with various analogs of NA. An important determinant in NA that is crucial to the base exchange reaction was shown to be the 2-position of the pyridine ring. Neither pyridine-2-carboxylate nor 2-methyl-NA support the exchange reaction. The neg. charge and the position of the 3-carboxyl group ware nonessential since both pyridine-3-carbinol and pyridine-4-carboxylate support the base exchange reaction. In addition to the information on the structure-activity relationships of NAADP and NA, this study also demonstrates the utility of the base exchange reaction as a general approach for synthesizing NAADP analogs.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Linxiao’s team published research in Catalysis Science & Technology in 9 | CAS: 636-73-7

Catalysis Science & Technology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.

Chen, Linxiao published the artcileSulfate promotion of selective catalytic reduction of nitric oxide by ammonia on ceria, SDS of cas: 636-73-7, the publication is Catalysis Science & Technology (2019), 9(8), 1802-1815, database is CAplus.

NO selective catalytic reduction by NH₃ (NH₃-SCR) is a promising technol. to control NO_x emissions. A recently discovered sulfate promotion effect in this reaction was thoroughly examined over CeO₂. Sulfates from different organic S precursors all exhibited a promoting effect. Mechanistic studies generated a reaction network which included Langmuir-Hinshelwood and Eley-Rideal mechanisms. Sulfates were shown to be versatile promoters with multiple functions: tuning reactant adsorption toward a more balanced intermediate coverage by creating strong Lewis acid sites; facilitating *NH₂ formation; and suppressing NH₃ ammonia oxidation via oxygen deactivation. A comparison between sulfates and the classic inorganic promoter, FeO_x, showed sulfates are more effective, particularly at high temperature This was mainly attributed to the high coverages of Eley-Rideal intermediates and low NH₃ oxidation activity on sulfated CeO₂. This work provided a fundamental understanding of the role of surface sulfates in NH₃-SCR; essential under actual operation conditions. This understanding presents an opportunity to design future catalysts with high durability and low cost.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kiani, Adeleh’s team published research in Journal of Sulfur Chemistry in 35 | CAS: 636-73-7

Journal of Sulfur Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application In Synthesis of 636-73-7.

Kiani, Adeleh published the artcileDirect synthesis of sulfonyl azides from sulfonic acids, Application In Synthesis of 636-73-7, the publication is Journal of Sulfur Chemistry (2014), 35(2), 119-127, database is CAplus.

A one-pot process for the synthesis of various sulfonyl azides (RSO₂N₃) by treating sulfonic acids with PPh₃-trichloroisocyanuric acid-sodium azide at room temperature was described. A wide range of arenesulfonyl and alkanesulfonyl azides was obtained in excellent yields under mild conditions.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Prescott, B. et al. published their research in Farmaco, Edizione Scientifica in 1966 |CAS: 636-73-7

Pyridine-3-sulfonic acid(cas:636-73-7) belongs to pyridine-derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of Pyridine-3-sulfonic acid

Prescott, B.; Stone, H. J. published an article in 1966, the title of the article was Means of increasing the tolerated dose of streptomycin in mice. Certain sulfonic acids.Reference of Pyridine-3-sulfonic acid And the article contains the following content:

With a 10 mg. dose of streptomycin, which was tolerated by only 7% of Swiss white and 12% of DBA mice, simultaneous administration of sulfanilic acid (25 mg.) or 6-thymolsulfonic acid (25 mg.) increased the tolerance to 93% of the Swiss white and 100% of the DBA mice tested. Sixty-seven percent of the Swiss white and 95% of the DBA mice survived 20 mg. streptomycin given concomitantly with the adjuvants. Pyridine-3-sulfonic acid (25 mg.) produced 90% survival in both strains of mice and dl-10-camphorsulfonic acid produced 83 and 100% survival in Swiss white and DBA mice, resp. Sixty percent of the mice tested survived 20 daily doses of 10 mg. streptomycin plus 25 mg. sulfanilic acid. The presence of free streptomycin in the blood of treated mice was demonstrated by the ability of serums to inhibit in vitro growth of Mycobacterium tuberculosis while the normal serum controls had no inhibitory action. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Reference of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elliott, Fred C. et al. published their research in Mich. State Univ., Agr. Expt. Sta., Quart. Bull. in 1963 |CAS: 636-73-7

Elliott, Fred C. published an article in 1963, the title of the article was The isolation of anti-metabolites from individual alfalfa plants. I. Cold water and paper chromatographic extraction techniques.SDS of cas: 636-73-7 And the article contains the following content:

Metabolites inhibiting growth of meadow vole weanlings were extracted from individual alfalfa clones using a combination of cold-water and paper-chromatographic techniques. Employment of 2 different solvent systems and 3 chromatographic papers facilitated the separation of a series of N base compounds Comparisons of Rf values and staining reactions with known compounds permitted tentative identification of a few compounds Water eluates from an area of the 3rd chromatographic paper gave a 3-fold increase in antimetabolic activity over at least 3 other areas of the chromatogram. The antimetabolic activity of an addnl. clone was phys. fractionated into 4% of the dry meal through air-separation on turbomilling equipment. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Littman, M. L. et al. published their research in Mycopathologia & Mycologia Applicata in 1964 |CAS: 636-73-7

Littman, M. L.; Miwatani, T. published an article in 1964, the title of the article was Effect of water-soluble vitamins and their analogs on the growth of Candida albicans. III. p-Aminobenzoic acid, nicotinic acid, inositol, and their analogs.Safety of Pyridine-3-sulfonic acid And the article contains the following content:

cf. CA 61, 7408b. A partial requirement for p-aminobenzoic acid (I), nicotinic acid (II), and inositol (III) by C. albicans was demonstrated. Analogs of I and II inhibited growth in the absence of the resp. vitamins; this effect was reversed upon addition of the vitamin. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nakamura, Mitsuru et al. published their research in Rev. Biol. Trop. Univ. Costa Rica in 1962 |CAS: 636-73-7

Nakamura, Mitsuru; Pitsch, Bonnie L. published an article in 1962, the title of the article was Stimulation of respiratory activity of Shigella sonnei by certain nitrogenous compounds.COA of Formula: C5H5NO3S And the article contains the following content:

Nicotinic acid (I), nicotinamide (II), tryptophan, pyridine-3-sulfonic acid (III), aspartic acid (IV), thiamine, glutamic acid, and asparagine all stimulated the respiratory activity of S. sonnei. Stimulation by II was approx. 100 times and III approx. twice as great as that by I. Maximum stimulation was shown by IV. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).COA of Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Henneberry, T. J. et al. published their research in Journal of Economic Entomology in 1966 |CAS: 636-73-7

Henneberry, T. J.; Kishaba, A. N. published an article in 1966, the title of the article was Effects of some chemosterilants on the viability of eggs, fecundity, mortality, and mating of the cabbage looper.Name: Pyridine-3-sulfonic acid And the article contains the following content:

Tepa, metepa, or apholate fed to moths of Trichoplusia ni induced variable degrees of sterility. Male moths fed tepa did not mate so frequently as untreated males. Tepa applied as a spray induced complete sterility in cabbage looper males treated when 1-4 days old. Untreated female moths mated to males sprayed with tepa produced about the same number of eggs as females of untreated pairs. Egg viability decreased with increasing concentrations of tepa. Tepa-sprayed males mated as frequently as untreated males, but abnormal copulations in which males were unable to sep. from females occurred more frequently after tepa treatment than in groups of untreated males. Females sprayed with tepa laid fewer eggs than females of untreated pairs. Females sprayed with concentrations of 2 and 4% tepa laid few or no eggs and none hatched. Mortality of both male and female moths sprayed with tepa was higher at the end of the 8-day test period than that of untreated moths. Metepa and apholate were less effective than tepa in sterilizing either sex. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Name: Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ridgway, R. L. et al. published their research in Journal of Economic Entomology in 1966 |CAS: 636-73-7

Ridgway, R. L.; Gorzycki, L. J.; Lindquist, D. A. published an article in 1966, the title of the article was Effect of metabolite analogs on larval development and ovi-position in the boll weevil.Reference of Pyridine-3-sulfonic acid And the article contains the following content:

Eighteen compounds were evaluated for their effects on larval development or oviposition or both in Anthonomus grandis. Methotrexate, 5-fluoroorotic acid, and 5-fluorouracil were among the most active compounds tested. The addition of uracil and RNA to adult diets containing 5-fluoroorotic acid and 5-fluorouracil partially reversed their effect on oviposition. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Reference of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gelboin, Harry V. et al. published their research in Experimental Medicine and Surgery in 1966 |CAS: 636-73-7

Gelboin, Harry V. published an article in 1966, the title of the article was Drugs and protein synthesis.Application of 636-73-7 And the article contains the following content:

Methylcholanthrene (I) and phenobarbital (II) are both capable of inducing specific messenger RNA and enzyme synthesis. Treatment of rats with I elevates tissue hydroxylase activity 7-30-fold at 14 hrs. The increase is lowered or prevented by protein synthesis inhibitors actinomycin D and puromycin. During a 20-min. pulse labeling, the liver microsomes of rats treated with I or II showed a greater amino acid incorporation than control microsomes. This increased amino acid incorporation is not the result of altered cofactor levels, activation of pre-existing enzymes, altered stability of messenger RNA, or to drug-induced changes in the endogenous pool of amino acids. L-Phenylalanine-U-14C incorporation in the microsomes from rats treated with I contain an increased level of polyuridylic acid and are more sensitive to added polyuridylic acid than control microsomes. Pretreatment of rat liver nuclei with I results in an increased level of orotic-14C incorporation into RNA and in an elevated RNA/DNA ratio. The RNA present in nuclei of rats treated with I had greater messenger RNA activity in the Nirenberg Escherichia coli protein synthesizing system than did RNA from similarly isolated control nuclei. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem