Reference of 65550-77-8, Adding some certain compound to certain chemical reactions, such as: 65550-77-8, name is 2-Bromo-5-chloro-3-methylpyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65550-77-8.
10201] Under nitrogen condition, 2-bromine-3-methyl-5-chioropyridine (400.00 mg, 1.94 mmol, 1.00 eq), WX1313-3-1 (465.61 mg, 2.32 mmol, 1.20 eq), sodium tert-butoxide (372.35 mg, 3.87 mmol, 2.00 eq), 1,1?-binaphthyl-2,2?-bis (diphenylphosphino) (241.26mg, 387.47 tmol, 0.20 eq) and tris(dibenzylideneacetone)dipalladium (177.40 mg, 193.73 tmol, 0.10 eq) were dissolved in anhydrous methylbenzene (10.00 mE). The mixture was stirred at 90 C. for 12 h. After reaction, the reaction liquid was dried by rotary evaporation to obtain the crude. The crude was purified by column chromatography (ethyl acetate: petroleum ether=1.-20%) to obtain WXO11-1. ?H NMR (400 MHz, CDC13) oeppm: 7.96 (d, J=2.00 Hz, 1H), 7.22 (s, 1H), 4.17-4.06 (m, 1H), 3.68- 3.61 (m, 1H), 3.58-3.46 (m, 2H), 3.41-3.31 (m, 1H), 2.07 (s, 3H), 1.99-1.86 (m, 1H), 1.84-1.67 (m, 2H), 1.65-1.60 (m, 1H), 1.59 (s, 9H).
According to the analysis of related databases, 65550-77-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SHENZHEN SALUBRIS PHARM CO LTD.; Wu, Chengde; Yan, Jie; Xu, Wenjie; Yu, Tao; Li, Ning; Chen, Shuhui; US2018/305346; (2018); A1;,
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