Category: 65977-55-1

Synthetic Route of 65977-55-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65977-55-1, name is 5-Chlorothieno[3,2-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

(A) A mixture of 1019 5-chlorothieno[3,2-b]pyridine (1.8 g, 10.6 mmol), PdCl2(dppf).CH2Cl2 (866 mg, 1.06 mmol) and 57 Et3N (3 mL) in 21 MeOH (15 mL) was stirred overnight at 110 C. under an atmosphere of CO (g) (60 atm). After cooling to rt, the reaction was quenched by the addition of satd. aq NH4Cl (50 mL) and the resulting solution was extracted with EtOAc (3×50 mL). The combined organic extracts were dried (Na2SO4), filtered and concentrated under reduced pressure. The resultant residue was purified by silica gel chromatography (0-25% EtOAc/petroleum ether) to afford 1020 methyl thieno[3,2-b]pyridine-5-carboxylate (1.7 g, 82%), as a yellow solid. LC/MS: mass calcd. for C9H7NO2S: 193.02, found: 193.8 [M+H]+.

According to the analysis of related databases, 65977-55-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Janssen Pharmaceutica NV; Meegalla, Sanath; Player, Mark R.; Huang, Hui; Winters, Michael P.; (98 pag.)US2017/291908; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 65977-55-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65977-55-1, name is 5-Chlorothieno[3,2-b]pyridine, molecular formula is C7H4ClNS, molecular weight is 169.63, as common compound, the synthetic route is as follows.

1.00 g of 5-Chloro-thieno[3,2-b]pyridine (5.91 mmol), 497 mg of sodium bicarbonate (5.91 mmol), 1.54 g of potassium hydrogenphosphate (8.87 mmol) and 1.07 g of magnesium sulfate (8.87 mmol) are placed in a flask with 50 ml of chloroform. The reaction mixture is stirred under reflux for 30 min. 0.55ml of Bromine (10.82 mmol) is added and stirred under reflux overnight. 0.55 ml of Additional EPO bromine (10.82 mmol) is added and stirred under reflux for 1 day. The reaction mixture is cooled to room temperature and water and CH2Cl2 are added. Organic layer is separated. The water layer is adjusted to pH = 14 with 5N NaOH and extracted with CH2Cl2. All organic layers are combined together and dried over Na2SO4 and evaporated. The crude product is applied onto a silica-gel chromatography column (Hexane: AcOEt = 5:1) to give 796 mg of the title compound (549^.1H-NMR(CDCI3): 8.12(d, IH, J=7.9Hz), 7.81(s, IH), 7.36(d, IH, J=7.9Hz) ppm.

Statistics shows that 65977-55-1 is playing an increasingly important role. we look forward to future research findings about 5-Chlorothieno[3,2-b]pyridine.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/107784; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem