Related Products of 66093-07-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 66093-07-0, name is 5,6-Dimethylpyridin-3-amine. A new synthetic method of this compound is introduced below.
Under inert atmosphere, 5,6-dimethyl-3-amino-pyridine (512 mg, 4.2 mmol) was dissolved in di- chloromethane (15 ml.) and treated with NEt3 (424 mg, 4.2 mmol). The mixture was cooled to 0 C, treated with a solution of 2-benzyl-2,4-dimethyl-pentanoyl chloride (553 mg, 2.3 mmol) in di- chloromethane (3 ml_), stirred at 0 C for 20 min and subsequently at 25 C over night. Water was added and phases were separated. The aq. phase was extracted with dichloromethane and the combined organic phases were washed with aq. sat. NH4CI solution, aq. sat. NaHCC>3 solution, and brine, dried over MgS04, and evaporated. Column chromatography (S1O2; cyclo- hexane/ethyl acetate 2:1) yielded Target Molecule Ex-80 (550 mg, 73%) as colorless powder.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,66093-07-0, 5,6-Dimethylpyridin-3-amine, and friends who are interested can also refer to it.
Reference:
Patent; BASF SE; SEET, Michael; WOLF, Antje; MUELLER, Bernd; RIEDIGER, Nadine; FEHR, Marcus; MENTZEL, Tobias; GROTE, Thomas; RUDOLF, Georg Christoph; LOHMANN, Jan Klaas; WINTER, Christian; GRAMMENOS, Wassilios; WIEBE, Christine; TERTERYAN-SEISER, Violeta; ESCRIBANO CUESTA, Ana; (200 pag.)WO2019/154663; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem