Category: 676339-81-4

Reference of 676339-81-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.676339-81-4, name is 6-(4-Carboxyphenyl)nicotinic acid, molecular formula is C13H9NO4, molecular weight is 243.2149, as common compound, the synthetic route is as follows.

(1) Add equimolar amounts of Zn (NO3) 2.6H2O (0.149g, 0.5mmol) and H2cpn (0.12g, 0.5mmol) to 12mL DMF solvent, and then stir for 10 minutes;(2) Add the material in step 1 to a 23mL polytetrafluoroethylene reactor, maintain a constant temperature of 130 C for 72 hours under autogenous pressure, and then drop to room temperature at a rate of 5 C / h;(3) The mixture in step 2 is filtered, the crystals are collected, washed with DMF solvent and dried to obtain colorless crystals.(4) Filter the product, collect the crystals, and dry to obtain colorless crystals.The yield was calculated to be 59% based on H2cpn.

Statistics shows that 676339-81-4 is playing an increasingly important role. we look forward to future research findings about 6-(4-Carboxyphenyl)nicotinic acid.

Reference:
Patent; Zhaoqing University; Ma Deyun; Yan Peng; Zhou Yiping; Mai Xufeng; Wu Yinbing; Liu Fumeilin; Chen Lilin; (9 pag.)CN111072693; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 676339-81-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 676339-81-4, name is 6-(4-Carboxyphenyl)nicotinic acid, molecular formula is C13H9NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) Add equimolar amounts of Co (NO3) 2.6H2O (0.145g, 0.5mmol) and H2cpn (0.12g, 0.5mmol) to 12mL dmf solvent, and then stir for 20 minutes;(2) Add the material in step 1 to a 23mL polytetrafluoroethylene reactor, maintain a constant temperature of 130 C for 72 hours under autogenous pressure, and then drop to room temperature at a rate of 5 C / h;(3) The mixture in step 2 is filtered, the crystals are collected, washed with dmf solvent and dried,Purple crystals are obtained.(4) Filter the product, collect the crystals, and dry to obtain purple crystals.According to the calculation of H2cpn, the yield was 48%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 676339-81-4, 6-(4-Carboxyphenyl)nicotinic acid.

Reference:
Patent; Zhaoqing University; Ma Deyun; Liang Fenglan; Tan Liang; Huang Yewei; Qin Jiayan; Shen Yijun; (7 pag.)CN111057113; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem