Adding a certain compound to certain chemical reactions, such as: 686279-09-4, Ethyl 4,6-dichloro-2-methylnicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 686279-09-4, blongs to pyridine-derivatives compound. SDS of cas: 686279-09-4
THF (52.3 mL) was cooled to 0C in a dry round bottomed flask under an atmosphere of N2 gas. Ethyl 4,6-dichloro-2-methylnicotinate (4.60 mL, 26.1 mmol) was then added followed by diisobutylaluminum hydride (57.5 mL, 57.5 mmol). The reaction was stirred at 0C for 3 h. The reaction was then poured into cold saturated sodium potassium tartrate solution. The mixture was stirred for several hours to allow the precipitate to dissolve, then the aqueous phase was extracted with EtOAc. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The residue was purified by flash chromatography (0-50% EtOAc/hexanes) to give (4,6-dichloro-2-methylpyridin-3-yl)methanol. MS ESI calc’d. for C7H8C12N0 [M+l]+ 192, found 192.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,686279-09-4, Ethyl 4,6-dichloro-2-methylnicotinate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIPFORD, Kathryn; FALCONE, Danielle; SLOMAN, David, L.; WITTER, David, J.; WO2015/94929; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem