Category: 6975-44-6

Adding a certain compound to certain chemical reactions, such as: 6975-44-6, Ethyl 4,6-dihydroxynicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 6975-44-6, blongs to pyridine-derivatives compound. SDS of cas: 6975-44-6

A mixture of scheme 1 compound 2 (8.01 g, 43.7 mmol) and POCl3 (70 mL, 751.1 mmol) was stirred at 110 C for 2h. TLC showed the starting material was consumed completely. After cooling down, most of POCl3 was removed under vacuum. The residue was mixed with ice-water, and neutralized with sodium carbonate solution. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous Na2S04 , concentrated to give scheme 1 compound 3 (8.7 g) as a brown solid which was used in the next step immediately without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6975-44-6, Ethyl 4,6-dihydroxynicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6975-44-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6975-44-6, name is Ethyl 4,6-dihydroxynicotinate, molecular formula is C8H9NO4, molecular weight is 183.16, as common compound, the synthetic route is as follows.

(Wallace, E., et.al, ibid.)’. A stirred suspension of compound ii (1.40 g, 7.67 mmol) in phosphorus (V) oxychloride (15 mL) was heated to 110C for 2.5 h with a guard tube (CaCl2) fitted. The reaction mixture was cooled to room temperature, reduced in vacuo and the resulting dark brown residue taken up in a small volume of DCM (~ 5 mL) and transferred dropwise onto a slurry of ice in water (250 mL) whilst stirring vigorously. The aqueous mixture was extracted with EtOAc (3 x 100 mL), the organic extracts combined, dried (MgS04) and evaporated to dryness to afford the crude product as an orange gum. Column chromatography (S1O2), eluting with 15: 1 Hexanes-EtOAc, afforded compound iii. (1.33 g, 6.14 mmol, 79%) as a colourless oil; [M+H]+ m/z = 220.0.

Statistics shows that 6975-44-6 is playing an increasingly important role. we look forward to future research findings about Ethyl 4,6-dihydroxynicotinate.

Reference:
Patent; BIOTA EUROPE LTD; TYNDALL, Edward Malcolm; CZAPLEWSKI, Lloyd George; FISHWICK, Colin William Gordon; YULE, Ian Andrew; MITCHELL, Jeffrey Peter; ANDERSON, Kelly Helen; PITT, Gary Robert William; WO2013/91011; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 6975-44-6, Adding some certain compound to certain chemical reactions, such as: 6975-44-6, name is Ethyl 4,6-dihydroxynicotinate,molecular formula is C8H9NO4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6975-44-6.

A. 4,6-Dichloro-nicotinic acid ethyl ester Diethyl 1,3-acetonedicarboxylate (10 mL, 49.5 mmol) was taken in 10 mL of acetic anhydride. To the solution was added trimethylorthoformate (8.2 mL, 49.5 mmol). The mixture was heated to 120 C. for 3 hours. The reaction was then cooled and 10 mL of NH4OH (30%) was added. After stirring for additional 1 hour, the solution was triturated for 3 times in CH2Cl2 to afford 7.3 g of an off-white solid. The solid was suspended in 10 mL of POCl3 and the mixture was heated at 100 C. for 6 hours. The reaction was cooled, quenched with water, and extracted 3 times with EtOAc. The organic layer was dried over Na2SO4 and concentrated in vacuo. Flash chromatography (EtOAc/Hexanes, 1:10 v/v) afforded the title compound as a white solid (6 g, 68%). 1H NMR (400 MHz, CDCl3) delta (ppm): 8.79 (s, 1H), 7.42 (s, 1H), 4.38 (q, J=7.1 Hz, 2H), 1.37 (t, J=7.1 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6975-44-6, Ethyl 4,6-dihydroxynicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Player, Mark R.; Huang, Hui; Hutta, Daniel A.; US2007/60577; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem