Category: 69872-17-9

Electric Literature of 69872-17-9 ,Some common heterocyclic compound, 69872-17-9, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

step 1 : A mixture of 4-bromo-lH-pyrrolo[2,3-c]pyridine (320 mg, 1.62 mmol), Pd(dppf)Cl2 (131 mg, 0.179 mmol), zinc cyanide (190 mg, 1.62 mmol), and zinc powder (21 mg, 0.324 mmol) in DMF (20 mL) was stirred at 120 C for 2 h. The reaction mixtue was cooled to RT andH20 (100 mL) was added. The reaction mixture extracted with EtOAc (3 x 50 mL). The organic layers were concentrated under reduced pressure and the crude residue was purified by S1O2 chromatography eluting with petroleum ether/EtOAc (1 :1) to afford 232 mg (99.8%) of lH-pyrrolo[2,3-c]pyridine-4-carbonitrile as yellow solid: MS (ESI) m/z: 144.2 [M+l] +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,69872-17-9, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy; WO2013/92940; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 69872-17-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69872-17-9, name is 4-Bromo-1H-pyrrolo[2,3-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of compound 4-bromo-1H-pyrrolo[2,3-c]pyridine (D16) (20.4 g), Zn(CN)2 (12.2 g) and Zn dust (1.4 g) in DMF (300 mL) was added Pd(dppf)CI2 (8.5 g). The reaction mixture was heated to 120 0C and stirred at that temperature for 2 h. The mixture was diluted with water, extracted with EtOAc. The organic layers were washed with water and brine, dried over anhydrous Na2SO4 , evaporated and purified on column chromatography to afford 1H-pyrrolo[2,3-c]pyridine-4-carbonitrile (D17) as white solid (3.9 g). deltaH (DMSO-d6, 400MHz): 6.69 (1 H, d), 7.93 (1 H, d), 8.57 (1 H, s), 9.01 (1 H, s), 12.30 (1H, s); MS (ES): C8H5N3 requires 143; found 144.0 (M+H+)

According to the analysis of related databases, 69872-17-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; LIN, Xichen; MENG, Qinghua; ZHANG, Haibo; LI, Chengyong; WO2010/145201; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem