Category: 7112-38-1

Electric Literature of 7112-38-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7112-38-1, name is 3-(Hydrazinylmethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-cyclobutyl-3-oxo-propionitrile (3.3 g, 32 mmol) in ethanol (100 mL) was added Example 85 A (3.9 g, 32 mmol) at rt. The solution was heated under reflux for 4 h. After cooling, the reaction mixture was concentrated and the residue was separated by flash chromatography (silica gel, 0-15% gradient MeOH in CH2Cl2) to give Example 85B (6.8 g). Yield: 93%. MS (DCI): m/z 229 (M+H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7112-38-1, 3-(Hydrazinylmethyl)pyridine.

Reference:
Patent; ABBOTT LABORATORIES; WO2007/95628; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7112-38-1, name is 3-(Hydrazinylmethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 3-(Hydrazinylmethyl)pyridine

General procedure: A mixture of 12a (12.6 g, 69.9 mmol), methylhydrazine (6.4 g,139 mmol), trifluoroacetic acid (10.7 mL, 144 mmol), and triethylamine (19.4 mL, 139 mmol) in 2-propanol (350 mL) was stirred at 80 C for 1 h, and then concentrated under reduced pressure. The residue was diluted with ethyl acetate, and washed with saturated NaHCO3 solution and brine. The organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure. The residuewas purified by column chromatography on silica gel with hexane/ethyl acetate as an eluent to give 13c (10.0 g, 75%). The compound 13b, 13e,f, 13h-o were prepared in a manner similar to that described for 13c. Yield (19 %). 1H NMR (300 MHz, CDCl3) delta 2.32 (3H, s), 5.34 (2H, s),6.16 (1H, s), 7.07-7.17 (2H, m), 7.22-7.30 (2H, m), 7.48-7.56 (1H,m), 7.72 (1H, d, J = 8.1 Hz), 8.28-8.40 (1H, m), 8.63 (1H, d, J = 4.0 Hz).

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Reference:
Article; Hasui, Tomoaki; Ohyabu, Norio; Ohra, Taiichi; Fuji, Koji; Sugimoto, Takahiro; Fujimoto, Jun; Asano, Kouhei; Oosawa, Masato; Shiotani, Sachiko; Nishigaki, Nobuhiro; Kusumoto, Keiji; Matsui, Hideki; Mizukami, Atsushi; Habuka, Noriyuki; Sogabe, Satoshi; Endo, Satoshi; Ono, Midori; Siedem, Christopher S.; Tang, Tony P.; Gauthier, Cassandra; De Meese, Lisa A.; Boyd, Steven A.; Fukumoto, Shoji; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5428 – 5445;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem